The reference interval of thyroid-stimulating hormone in Hong Kong Chinese

Chan, Antony C. S.; Iu, Yan Ping Heidi; Shek, Chi Chung

doi:10.1136/jcp.2010.087627

Cited by 15 publications

(9 citation statements)

References 22 publications

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“…The absolute concentrations of these antibodies were not compared in any of these papers. As to some antibodies, mostly in lithium-naive patients, we found higher concentration in female than in male subjects what may correspond to the results of Chan et al [5] obtained in the general population.…”

Section: Discussionsupporting

confidence: 91%

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No Connection between Long-Term Lithium Treatment and Antithyroid Antibodies

et al. 2019

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Introduction The studies on the effect of lithium treatment on antithyroid antibodies showed either a higher concentration of these antibodies in patients receiving lithium compared to those lithium-naive or no difference between these groups. In lithium-treated bipolar patients, some researchers pointed to an association between antithyroid antibodies and other features of thyroid dysfunction such as hypothyroidism and decrease of glomerular filtration rate. Methods We compared antithyroid antibodies in 98 patients (30 male, 68 female) with bipolar disorder, aged 62±13 years, who received lithium for 19±10 years to 39 patients (12 male, 27 female), aged 57±10 years, who were never treated with lithium. The antibodies against thyroid peroxidase (TPOAb), against thyroglobulin (TGAb), and thyroid-stimulating hormone (TSH) receptors (TSHRAb) were estimated. Results No difference in the percentages of antibodies occurrence was found between groups, although the concentrations of TGAb were higher in patients receiving lithium. In lithium-treated patients, the presence of TPOAb was associated with lower concentrations of free triiodothyronine and the presence of TGAb, with higher concentrations of TSH. In females, the levels of TGAb were associated with lower thyroid volume. The concentrations of TPOAb correlated positively with the duration of lithium therapy in males, and those of TPOAb and TGAb negatively, with such duration, in female patients. Conclusion The results obtained showed no significant connection between long-term lithium treatment and antithyroid antibodies. In bipolar patients receiving lithium longitudinally, antithyroid antibodies can be associated with some indexes of thyroid function. However, they behave differently in male and female patients.

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Section: Discussionsupporting

confidence: 91%

“…A gender effect on the thyroid antibodies was found in the general population. Chan et al [5] showed that the concentrations of TPOAb > 5.61 IU/mL and of antibodies against thyroglobulin (TGAb) > 4.11 IU/mL were more than twice as frequent in female than in male subjects.…”

Section: Introductionmentioning

confidence: 99%

No Connection between Long-Term Lithium Treatment and Antithyroid Antibodies

et al. 2019

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“…When persons who are thyroid antibody‐positive are excluded, the reference interval for TSH invariably falls . Addition of ultrasonography appears to add little in identifying persons with occult thyroid disease …”

Section: Discussionmentioning

confidence: 99%

Using a thyroid disease-free population to define the reference interval for TSH and free T4 on the Abbott Architect analyser

et al. 2016

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“…The upper limit of TSH was lowered to 3.6–3.7 mU/L [3, 15]. It was believed that the skewing right tail of the TSH distribution curve was caused by the inclusion of those with occult thyroid dysfunctions most representatively as HT.…”

Section: Discussionmentioning

confidence: 99%

Using Hashimoto thyroiditis as gold standard to determine the upper limit value of thyroid stimulating hormone in a Chinese cohort

Chen

Cui

et al. 2016

BMC Endocr Disord

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BackgroundSubclinical hypothyroidism, commonly caused by Hashimoto thyroiditis (HT), is a risk factor for cardiovascular diseases. This disorder is defined as merely having elevated serum thyroid stimulating hormone (TSH) levels. However, the upper limit of reference range for TSH is debated recently. This study was to determine the cutoff value for the upper normal limit of TSH in a cohort using the prevalence of Hashimoto thyroiditis as “gold” calibration standard.MethodsThe research population was medical staff of 2856 individuals who took part in health examination annually. Serum free triiodothyronine (FT3), free thyroxine (FT4), TSH, thyroid peroxidase antibody (TPAb), thyroglobulin antibody (TGAb) and other biochemistry parameters were tested. Meanwhile, thyroid ultrasound examination was performed. The diagnosis of HT was based on presence of thyroid antibodies (TPAb and TGAb) and abnormalities of thyroid ultrasound examination. We used two different methods to estimate the cutoff point of TSH based on the prevalence of HT.ResultsJoinpoint regression showed the prevalence of HT increased significantly at the ninth decile of TSH value corresponding to 2.9 mU/L. ROC curve showed a TSH cutoff value of 2.6 mU/L with the maximized sensitivity and specificity in identifying HT. Using the newly defined cutoff value of TSH can detect patients with hyperlipidemia more efficiently, which may indicate our approach to define the upper limit of TSH can make more sense from the clinical point of view.ConclusionsA significant increase in the prevalence of HT occurred among individuals with a TSH of 2.6–2.9 mU/L made it possible to determine the cutoff value of normal upper limit of TSH.

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The reference interval of thyroid-stimulating hormone in Hong Kong Chinese

Cited by 15 publications

References 22 publications

No Connection between Long-Term Lithium Treatment and Antithyroid Antibodies

No Connection between Long-Term Lithium Treatment and Antithyroid Antibodies

Using a thyroid disease-free population to define the reference interval for TSH and free T4 on the Abbott Architect analyser

Using Hashimoto thyroiditis as gold standard to determine the upper limit value of thyroid stimulating hormone in a Chinese cohort

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