The Reduction Rate of Serum Sodium and Mortality in Patients Undergoing Continuous Venovenous Hemofiltration for Acute Severe Hypernatremia

Ma, Feng; Liu, Yirong; Bai, Ming; Li, Yangping; Yu, Yan; Zhou, Mi; Wang, Pengbo; He, Lijie; Huang, Chen; Wang, Hanmin; Sun, Shan

doi:10.1016/j.amjms.2016.06.002

Cited by 4 publications

(2 citation statements)

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“…The patient was treated with 6 L of free water within 30 min and survived without sequelae. However, in a study that explored the effects of overcorrection of acute hypernatremia on patients, a serum sodium correction rate > 1 mEq/L/h (HR = 1.89; 95% CI: 1.03–3.47) was a cause of death in critically ill patients ( 27 ). Given the above contradictory results, large-scale prospective randomized controlled trials are needed for further evaluation in the future.…”

Section: Conventional Treatment Of Hypernatremia In Brain Injury and ...mentioning

confidence: 99%

Diagnosis and treatment of brain injury complicated by hypernatremia

Bai

et al. 2022

Front. Neurol.

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Hypernatremia is a common electrolyte disorder in patients with brain injury. The mortality of brain injury patients with severe hypernatremia may be as high as 86.8%. The efficacy of conventional treatment for hypernatremia is limited. Continuous renal replacement therapy (CRRT) can slowly, controllably, and continuously reduce the blood sodium concentration and gradually become an important treatment for severe hypernatremia patients. This review aims to provide important information for clinicians and clinical researchers by describing the etiology, diagnosis, hazards, conventional treatment, and CRRT treatment of hypernatremia in patients with traumatic brain injury.

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Section: Conventional Treatment Of Hypernatremia In Brain Injury and ...mentioning

confidence: 99%

Diagnosis and treatment of brain injury complicated by hypernatremia

Bai

et al. 2022

Front. Neurol.

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“…The rate of reduction of [Na] in hypernatremic patients treated with CRRT should be monitored. In a retrospective study, the hourly rate of reduction in [Na] > 1 mmol/L and dependency on vasopressors were shown to be risk factors for mortality ( 146 ). In contrast, a prospective study found no relation between the rate of change in [Na] during CRRT and mortality in dysnatremic patients ( 147 ).…”

Section: Reviewmentioning

confidence: 99%

Dysnatremias in Chronic Kidney Disease: Pathophysiology, Manifestations, and Treatment

Arzhan

Lew²,

Ing³

et al. 2021

Front. Med.

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The decreased ability of the kidney to regulate water and monovalent cation excretion predisposes patients with chronic kidney disease (CKD) to dysnatremias. In this report, we describe the clinical associations and methods of management of dysnatremias in this patient population by reviewing publications on hyponatremia and hypernatremia in patients with CKD not on dialysis, and those on maintenance hemodialysis or peritoneal dialysis. The prevalence of both hyponatremia and hypernatremia has been reported to be higher in patients with CKD than in the general population. Certain features of the studies analyzed, such as variation in the cut-off values of serum sodium concentration ([Na]) that define hyponatremia or hypernatremia, create comparison difficulties. Dysnatremias in patients with CKD are associated with adverse clinical conditions and mortality. Currently, investigation and treatment of dysnatremias in patients with CKD should follow clinical judgment and the guidelines for the general population. Whether azotemia allows different rates of correction of [Na] in patients with hyponatremic CKD and the methodology and outcomes of treatment of dysnatremias by renal replacement methods require further investigation. In conclusion, dysnatremias occur frequently and are associated with various comorbidities and mortality in patients with CKD. Knowledge gaps in their treatment and prevention call for further studies.

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