The Reduction of Methemoglobin Levels by Antioxidants

Stratton, Lewis P.; Rudolph, Alan S.; Knoll, Wayne K.; Bayne, Sandy; Farmer, Martha

doi:10.3109/03630268808998035

Cited by 29 publications

(27 citation statements)

References 12 publications

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“…As another strategy, various antioxidants like ascorbic acid and vitamin E have been examined. Neither a dose of 1000 mg ascorbic acid/day [89, 127, 146] nor 800 mg vitamin E had a significant effect on dapsone-induced haemolysis [127]. Only simultaneous application of ascorbic acid and vitamin E exerted an inhibitory effect on met-Hb formation [127].…”

Section: Conclusion For Treating Patients With Dapsonementioning

confidence: 99%

Dapsone in dermatology and beyond

2013

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Dapsone (4,4′-diaminodiphenylsulfone) is an aniline derivative belonging to the group of synthetic sulfones. In 1937 against the background of sulfonamide era the microbial activity of dapsone has been discovered. Shortly thereafter, the use of dapsone to treat non-pathogen-caused diseases revealed alternate antiinflammatory mechanisms that initially were elucidated by inflammatory animal models. Thus, dapsone clearly has dual functions of both: antimicrobial/antiprotozoal effects and anti-inflammatory features similarly to non-steroidal anti-inflammatory drugs. The latter capabilities primarily were used in treating chronic inflammatory disorders. Dapsone has been investigated predominantly by in vitro methods aiming to get more insights into the effect of dapsone to inflammatory effector cells, cytokines, and/or mediators, such as cellular toxic oxygen metabolism, myoloperoxidase-/halogenid system, adhesion molecules, chemotaxis, membrane-associated phospholipids, prostaglandins, leukotrienes, interleukin-8, tumor necrosis factor α, lymphocyte functions, and tumor growth. Moreover, attention has been paid to mechanisms by which dapsone mediates effects in more complex settings like impact of lifespan, stroke, glioblastoma, or as anticonvulsive agent. Additionally, there are some dermatological investigations in human being using dapsone and its metabolites (e.g., leukotriene B4-induced chemotaxis, ultraviolet-induced erythema). It could be established that dapsone metabolites by their own have anti-inflammatory properties. Pharmacology and mechanisms of action are determining factors for clinical use of dapsone chiefly in neutrophilic and/or eosinophilic dermatoses and in chronic disorders outside the field of dermatology. The steroid-sparing effect of dapsone is useful for numerous clinical entities. Future avenues of investigations will provide more information on this fascinating and essential agent.

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Section: Conclusion For Treating Patients With Dapsonementioning

confidence: 99%

Dapsone in dermatology and beyond

2013

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“…20 Heating solution samples with just glucose or mixtures of glucose plus trehalose (but not just trehalose) at near 100°C does result in the appearance of reduced protein as well as clear signs of protein denaturation (turbidity and precipitation). However, in the trehalose glass, denaturation is prevented.…”

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confidence: 98%

Trehalose Glass-Facilitated Thermal Reduction of Metmyoglobin and Methemoglobin

Ray

Friedman

2002

J. Am. Chem. Soc.

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The reduction of ferric derivatives of hemeproteins in solution typically requires moderate to strong reducing agents. Reducing sugars are not adequate to reduce ferric myoglobins or hemoglobins under solution conditions favorable to protein stability. We find that embedding aquo-met derivatives of horse myoglobin and human adult hemoglobin in a glucose-doped glassy matrix derived from trehalose facilitates an efficient thermally initiated reduction that yields a five-coordinate high-spin ferrous heme. The trehalose glass plays a central role by stabilizing the reduction-prone bis-histidine heme (hemichrome) intermediate under the high-temperature conditions that favor the open reducing form of glucose. Due to glass-imposed limitations on conformational reorganization, this process has clear applications in biophysics where it can be used to generate nonequilibrium ferrous derivatives having the initial conformation of the aquo-met derivative. Since the glassy matrix can be redissolved to release the embedded protein, this technique is not only a basis for a relatively benign method of reducing hemoglobin-based blood substitutes that have undergone autoxidation during storage but may also be a way to reactivate stored proteins that have undergone oxidation.

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“…Propanil has been shown to bind to haemoglobin in mammals and cause the formation of methaemoglobinaemia (Chow andMurphy 1975, McMillan et al 1990). In addition, propanil may also deplete red blood cell glutathione which would prevent the normal reduction of haemoglobin (Stratton et al 1988). Consequently, methaemoglobinaemia may be a possible mechanism of Propanil in catjish 1023 toxicity for propanil in fish.…”

Section: Discussionmentioning

confidence: 98%

Distribution and elimination of the herbicide propanil in the Channel Catfish (Ictalurus punctatus)

Schlenk

Moore

1993

Xenobiotica

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1. The uptake, elimination and tissue distribution of total radioactivity derived from the herbicide, [14C]propanil (3,4-dichloropropionanilide) and its metabolites were examined in individual farm-raised Channel Catfish which were exposed for 24 h to water containing 1 ppm of 14C-propanil under static conditions. Uptake and elimination of total radioactivity was monitored in individual animals over time in respective exposure (24 h) and depurating (144 h) aquaria. 2. Maximal uptake was reached between 8 and 12 h with approx. 38% of the absorbed radioactivity remaining in the animal after 144 h of depuration. Whole body depuration of radioactivity was biphasic with alpha and beta half-lives of 20 and 444 h, respectively. 3. Tissue distribution of total radioactivity was monitored at various time points in 12 tissues and bile over 48 h. Intestine, abdominal fat and liver possessed the greatest levels of radioactivity per gram of tissue over time. Radiolabel was shown to slowly increase in bile and intestine indicating biliary excretion as a possible pathway of metabolite elimination. 4. Bile possessed approx. 104 nmol (23%) of the remaining radioactivity in fish after 48 h. Other whole tissues possessing > 10% of radiolabel after 48 h were blood (83.5 nmol, 19% of the administered dose) and muscle (190 nmol, 43%).

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The Reduction of Methemoglobin Levels by Antioxidants

Cited by 29 publications

References 12 publications

Dapsone in dermatology and beyond

Dapsone in dermatology and beyond

Trehalose Glass-Facilitated Thermal Reduction of Metmyoglobin and Methemoglobin

Distribution and elimination of the herbicide propanil in the Channel Catfish (Ictalurus punctatus)

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