The reduction of IL-6 gene expression, pAKT, pERK1/2, pSTAT3 signaling pathways and invasion activity by gallic acid in prostate cancer PC3 cells

In VitroProtective Effects ofLycium barbarumBerries Cultivated in Umbria (Italy) on Human Hepatocellular Carcinoma Cells

“…In fact, Chen et al described a correlation between flavonoids and antiproliferative activities of Rhamnus davurica [52] and Xia et al demonstrated a potential antihepatocellular carcinoma agent of flavonoids, using HepG2 cell line [38]. Among flavonoids, gallic acid is known to be an anticancer agent since it reduces cell survival, proliferation, and invasion in PC3 cells by downregulating IL-6 with consequent reduction of pSTAT3, pERK1/2, and pAKT signaling proteins [53]. At the moment the phytochemical composition of LBBs from Umbria is unknown.…”

Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties

“…As presented in Table 4 and Fig. 1, H 2 O extract was almost inefficient 50 or other type of tumors can be targeted with this plant constituents. Varying in efficacy of used A. vulgaris extract against tested cell lines might be ascribed to the differences in content, concentration and ratio of biologically active compounds with proven anticancer activity.…”

Effects of Thymoquinone on IL-6 Gene Expression and Some Cellular Signaling Pathways in Prostate Cancer PC3 Cells

“…The experiments were repeated 3 times for each concentration. Then, the cytotoxicity effects of TQ on PC3 cells were assessed by MTT assay (24,25). Briefly, after treating cells for 48 hours, the culture medium was removed and cells were exposed to 100 µL colorless RPMI and 10 µL MTT (5 mg/mL in phosphate buffered saline (PBS) added to each well and incubated for 4 hours.…”