The REDUCED (A R andomisED stU dy C omparing standard systemic anticoagulation thE rapy to low D ose intracoronary anticoagulation therapy for elective percutaneous coronary intervention) trial. A novel pharmacologic regime for elective percutaneous coronary intervention

Arı, Hasan; Kivaç, Eylem; Arı, Selma; Emlek, Nadir; Çetinkaya, Seçkin; Celiloğlu, Nuran; Sarigul, O.Y.; Aydın, Cihan; Akkaya, Mehmet; Koca, Vedat; Bozat, Tahsin; Gürdoğan, Muhammet

doi:10.1080/ac.69.6.1000004

Acta Cardiologica

2014

DOI: 10.1080/ac.69.6.1000004

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The REDUCED (A R andomisED stU dy C omparing standard systemic anticoagulation thE rapy to low D ose intracoronary anticoagulation therapy for elective percutaneous coronary intervention) trial. A novel pharmacologic regime for elective percutaneous coronary intervention

Hasan Arı

Eylem Kivaç

Selma Arı

et al.

Abstract: This pilot study suggests that elective PCI could be safely performed with low-dose intracoronary UFH in the treatment of uncomplicated lesions and at a lower cost as compared to standard systemic anticoagulation.These results should be confirmed by further studies.

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Safety and efficacy of low dose or no heparinization in cerebral angiography: A randomized controlled study (SELECT trial)

Wang,

Luo,

Qin

et al. 2024

Brain Circulation

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INTRODUCTION: Although systemic heparinization is a widely used technique during digital subtraction angiography (DSA), heparin is associated with a variety of complications including hemorrhage, thrombocytopenia, and hematomas. This study aimed to investigate the safety and efficacy of microdose systemic heparinization or no heparinization on cerebral angiography for cerebrovascular diseases. MATERIALS AND METHODS: We conducted a prospective, single-blind, randomized controlled study on patients who ought to be experienced cerebrovascular examination and underwent DSA. Participants were randomized into three groups: regular-dose systemic heparinization, microdose systemic heparinization, and no heparinization. Information on patient demographics, laboratory tests, perioperative complications, and back pain scores was collected. Safety endpoints were defined as cerebral ischemic events and local complications of the puncture site. Efficacy endpoints were defined as the recovery of the patients. RESULTS: A total of 180 patients were enrolled in the study and randomized into one of three groups. Patients were on average 54.4 ± 10.6 years old and 71.6% were male. Among the three groups, there was no significant difference in the incidence of postoperative thrombotic or ischemic events (regular dose vs. microdose vs. no heparinization: 1.7% vs. 3.3% vs. 1.7%, P = 0.774). The microdose or no heparinization group; however, experienced a significantly lower rate of postoperative subcutaneous hematoma (15.0% vs. 3.3% vs. 0%, P = 0.002), as well as significantly less back pain (21.7% vs. 5.0% vs. 1.7%, P < 0.001) compared to the regular-dose heparinization group. CONCLUSIONS: Microdose heparinization or heparin-free cerebral angiography demonstrated similar safety to conventional heparinization but significantly reduced local complications of the puncture site and accelerated recovery. TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT06365398.

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Safety and efficacy of low dose or no heparinization in cerebral angiography: A randomized controlled study (SELECT trial)

Wang,

Luo,

Qin

et al. 2024

Brain Circulation

View full text Add to dashboard Cite

show abstract

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The REDUCED (A R andomisED stU dy C omparing standard systemic anticoagulation thE rapy to low D ose intracoronary anticoagulation therapy for elective percutaneous coronary intervention) trial. A novel pharmacologic regime for elective percutaneous coronary intervention

Abstract: This pilot study suggests that elective PCI could be safely performed with low-dose intracoronary UFH in the treatment of uncomplicated lesions and at a lower cost as compared to standard systemic anticoagulation.These results should be confirmed by further studies.

Cited by 1 publication

References 0 publications

Safety and efficacy of low dose or no heparinization in cerebral angiography: A randomized controlled study (SELECT trial)

Safety and efficacy of low dose or no heparinization in cerebral angiography: A randomized controlled study (SELECT trial)

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