The redox modulatory effects of SP/NK1R system: Implications for oxidative stress-associated disorders

“…The presence of AgNPs also facilitates the production of reactive oxygen species (ROS) that can effectively promote oxidative stress, and block the respiratory system, eventually causing cell death. 42 Furthermore, the cytotoxicity test was similarly carried out against a cancerous KB and a normal HEK-293 cell line (Fig. 6b).…”

Section: Bioactivitiesmentioning

confidence: 99%

Green synthesis of silver@graphene oxide nanocomposite for antibacterial, cytotoxicity assessment, and hydrogen peroxide electro-sensing

et al. 2023

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“…SP has been demonstrated to affect the cellular redox states through activating neurokinin1receptor (NK1R) (Ebrahimi et al. 2022 ). Asthma inflammation may be manifested as an imbalance between oxidative stress and antioxidant defense.…”

Section: Discussionmentioning

confidence: 99%

Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor

Zhang

et al. 2023

Pharmaceutical Biology

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“…Thereafter, many investigations have led to our current understanding that SP functions as an important mediator involved in a wide array of biological processes, including pain signaling, inflammation regulation, host defense response, and wound healing processes [ 14 , 15 , 16 , 17 ]. After its release, SP binds to, and subsequently primes, its functional receptors on the surface of effector cells, through which SP signals to several cellular signaling pathways and, consequently, exerts its multifaceted (patho)physiological functions [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Inflammation and Organ Injury the Role of Substance P and Its Receptors

Zhu

Bhatia

2023

IJMS

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Tightly controlled inflammation is an indispensable mechanism in the maintenance of cellular and organismal homeostasis in living organisms. However, aberrant inflammation is detrimental and has been suggested as a key contributor to organ injury with different etiologies. Substance P (SP) is a neuropeptide with a robust effect on inflammation. The proinflammatory effects of SP are achieved by activating its functional receptors, namely the neurokinin 1 receptor (NK1R) receptor and mas-related G protein-coupled receptors X member 2 (MRGPRX2) and its murine homolog MRGPRB2. Upon activation, the receptors further signal to several cellular signaling pathways involved in the onset, development, and progression of inflammation. Therefore, excessive SP–NK1R or SP–MRGPRX2/B2 signals have been implicated in the pathogenesis of inflammation-associated organ injury. In this review, we summarize our current knowledge of SP and its receptors and the emerging roles of the SP–NK1R system and the SP–MRGPRX2/B2 system in inflammation and injury in multiple organs resulting from different pathologies. We also briefly discuss the prospect of developing a therapeutic strategy for inflammatory organ injury by disrupting the proinflammatory actions of SP via pharmacological intervention.

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The redox modulatory effects of SP/NK1R system: Implications for oxidative stress-associated disorders

Cited by 13 publications

References 117 publications

Green synthesis of silver@graphene oxide nanocomposite for antibacterial, cytotoxicity assessment, and hydrogen peroxide electro-sensing

Green synthesis of silver@graphene oxide nanocomposite for antibacterial, cytotoxicity assessment, and hydrogen peroxide electro-sensing

Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor

Inflammation and Organ Injury the Role of Substance P and Its Receptors

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