The redox mechanism of ferrocene and its phytochemical and biochemical compounds in anticancer therapy: A mini review

Chaudhary, Anvita; Poonia, Kavita

doi:10.1016/j.inoche.2021.109044

Cited by 19 publications

(15 citation statements)

References 90 publications

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“…These amazing properties and diverse structure of ferrocene derivatives present them as potential candidates as anticancer agents against brain cancer cell lines (A-172). 42 …”

Section: Resultsmentioning

confidence: 99%

“…Iron-based organometallic compounds, such as ferrocene derivatives, have shown remarkable properties such as a low preparation cost, high stability, reduction–oxidation reversibility, catalytic activity, and ligand exchange capability. These amazing properties and diverse structure of ferrocene derivatives present them as potential candidates as anticancer agents against brain cancer cell lines (A-172) …”

Section: Resultsmentioning

confidence: 99%

“…These amazing properties and diverse structure of ferrocene derivatives present them as potential candidates as anticancer agents against brain cancer cell lines (A-172). 42 There are many probable mechanisms suggested in the literature for cancer cell death due to ferrocene-based anticancer agents. The potency may be due to the interruption of the redox homeostasis in cancer cells resulting in apoptosis, 42 DNA intercalation or fragmentation, 43 cell cycle arrest 44 or ROS generation in cell.…”

Section: Biological Evaluation Of Ferrocene-appended Bis-(indolyl)met...mentioning

confidence: 99%

“…42 There are many probable mechanisms suggested in the literature for cancer cell death due to ferrocene-based anticancer agents. The potency may be due to the interruption of the redox homeostasis in cancer cells resulting in apoptosis, 42 DNA intercalation or fragmentation, 43 cell cycle arrest 44 or ROS generation in cell. 45 The cancerous A-172 cell line is a glioblastoma cell line, which is related to the most aggressive stage of brain cancer.…”

Section: Biological Evaluation Of Ferrocene-appended Bis-(indolyl)met...mentioning

confidence: 99%

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Synthesis of a Zirconium Complex of an N,O-type p-tert-Butylcalix[4]arene and Its Application in Some Multicomponent Reactions

et al. 2022

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The synthesis and characterization of a new octahedral Zr(IV) complex of oxygen-depleted N , O -type calixarene ligand comprising two distal-functionalized pyrazole rings have been reported. The cone shape and structure of the prepared complex were confirmed univocally by single-crystal X-ray diffraction and NMR studies. The Zr metal lies at 2.091 Å from the plane of the calixarene ring. This complex has been utilized as an efficient catalyst for the synthesis of Biginelli adducts, bis(indolyl)methanes, and coumarins. This complex (Cl 2 Zr–calixarene) showed superior activity for these multicomponent reactions in comparison to the corresponding Ti(IV) and Zn(II) analogues. Ferrocene-appended bis(indolyl)methane, prepared using this catalyst, was also evaluated for its anticancer activity against the A-172 cell line.

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“…These amazing properties and diverse structure of ferrocene derivatives present them as potential candidates as anticancer agents against brain cancer cell lines (A-172). 42 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Biological Evaluation Of Ferrocene-appended Bis-(indolyl)met...mentioning

confidence: 99%

Section: Biological Evaluation Of Ferrocene-appended Bis-(indolyl)met...mentioning

confidence: 99%

See 2 more Smart Citations

Synthesis of a Zirconium Complex of an N,O-type p-tert-Butylcalix[4]arene and Its Application in Some Multicomponent Reactions

et al. 2022

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“…10 The anticancer effects are mainly attributed to the formation of reactive oxygen species (ROS) via the Fenton pathway 11 which induces DNA damage followed by cell death. 12 In the past decades, ferrocene derivatives with a broad range of biological activities, such as antimalarial, antitumor, 13,14 antiparasitic, antibacterial, antifungal, and antiviral 15 effects have been prepared.…”

Section: Introductionmentioning

confidence: 99%

Synthetic methods towards steroid-ferrocene conjugates

Skoda‐Földes¹,

Váradi²

2022

Arkivoc

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Steroid-ferrocene conjugates, in which a steroid skeleton is connected directly or via a linker group to the ferrocene moiety, have a broad scope of possible applications in medicinal or analytical chemistry as well as in materials science. They may integrate or even enhance many of the attractive properties of the components. Reactive functional groups of steroids and the ease in the conversion of ferrocene via aromatic substitution reactions offer a wide range of possibilities to attach the two skeletons to each other. This review summarizes the diverse methodologies used in the synthesis of conjugates, including classical organic reactions as well as the application of organometallic reagents and transition-metal catalyzed reactions.

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Oxidation states in metallocenes: A key mechanistic component in cancer alleviation

Das,

Chatterjee,

Shard

2024

Coordination Chemistry Reviews

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The redox mechanism of ferrocene and its phytochemical and biochemical compounds in anticancer therapy: A mini review

Cited by 19 publications

References 90 publications

Synthesis of a Zirconium Complex of an N,O-type p-tert-Butylcalix[4]arene and Its Application in Some Multicomponent Reactions

Synthesis of a Zirconium Complex of an N,O-type p-tert-Butylcalix[4]arene and Its Application in Some Multicomponent Reactions

Synthetic methods towards steroid-ferrocene conjugates

Oxidation states in metallocenes: A key mechanistic component in cancer alleviation

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