The red blood cell distribution width

Evans, Timothy C.; Jehle, Dietrich

doi:10.1016/0736-4679(91)90592-4

Cited by 316 publications

(273 citation statements)

References 14 publications

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“…Red blood cell distribution width (RDW) is a measure of the variability in size of circulating erythrocytes (anisocytosis) [3] and is routinely assessed in the evaluation of anaemia. Increased RDW levels are related to impaired erythropoiesis or erythrocyte degradation [3].…”

Section: Introductionmentioning

confidence: 99%

Association between red blood cell distribution width and macrovascular and microvascular complications in diabetes

et al. 2011

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Aims/hypothesis Red blood cell distribution width (RDW) has been reported to be a risk marker of morbidity and mortality for cardiovascular disease in various study populations. However, no studies have investigated the relationship between RDW and diabetes complications. We therefore evaluated RDW as a marker of macrovascular and microvascular complications in a nationally representative sample of the adult diabetes population in the USA. Methods A cross-sectional study was performed using the nationwide 1988 to 1994 data set from the Third National Health and Nutrition Examination Survey. The association between RDW quartiles and macrovascular and microvascular complications was evaluated in 2,497 non-pregnant adults aged 20 years and older and affected by diabetes. Logistic regression modelling was used to adjust for potential confounding.

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Section: Introductionmentioning

confidence: 99%

Association between red blood cell distribution width and macrovascular and microvascular complications in diabetes

et al. 2011

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“…The RDW is a marker of disturbance developing during differentiation and maturation of erythrocytes due to chronic inflammation and oxidative stress [11]. There are data in the literature suggesting that RDW is a marker of chronic inflammation and RDW increases with inflammation [7,8].…”

Section: Discussionmentioning

confidence: 99%

Correlation between red cell distribution width and grade of hepatic steatosis and liver enzymes in patients with Non-Alcoholic steatohepatitis

Doğan¹,

Doğan²,

Ekinci³

et al. 2017

Med-Science

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Red cell distribution width (RDW) is a marker of chronic inflammation. Hepatic diseases are often associated with several hematological complications; therefore, high levels of RDW are seen in hepatic diseases. Given the fact that factors which cause non-alcoholic steatohepatitis such as inflammation, oxidative stress, free oxygen radicals, and inflammatory cytokines may have a role in the discrepancy in the erythrocyte volume, we aimed to investigate the relationship between RDW and hepatic enzymes and Grade of hepatic steatosis. A total of 120 patients with non-alcoholic steatohepatitis using abdominal ultrasonography which was performed by a gastroenterology specialist, were included in the study. Biochemical analysis, complete blood count, other blood tests were performed. Spearman's Rho correlation test was used to analyze the relationship between the parameters and p value was accepted significant if it's <0.05. As a result of our study, there was no significant relationship between RDW and liver steatosis degree (p: 0.704). Also, significant relationship was not found between RDW and alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT) and lactate dehydrogenase (LDH) ( p values were 0,223, 0,856, 0,318, 0,597, 0,195 consecutively). In our study, we tried to find an answer to if there is a relationship between RDW alterations and inflammation which takes place in the pathogenesis of non-alcoholic steatohepatitis. As a result, we found no significant correlation between the RDW values and the degree of steatosis of liver and also liver enzymes.

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“…[55] In the large cohort study by Lippi et al [58] the authors established a significant association between RDW and other inflammatory markers as predictors of CVD or heart failure. A recent study by Vaya et al [59] documented significant association of increased RDW in active d to controls.…”

Section: Rbc Morphologymentioning

confidence: 99%

“…It is the coefficient of variation of the RBC volume, calculated as the ratio of the standard deviation of the RBC volume and the MCV. [55] Anything more than 14% is considered as high RDW, which corresponds to 95 th percentile of RDW for the reference population in the National Health and Nutrition Examination Survey IIII study. [55] Recently there have been numerous reports speculating about the role of RDW in predicting morbidity and mortality in heart failure patients.…”

Section: Rbc Morphologymentioning

confidence: 99%

“…[55] Anything more than 14% is considered as high RDW, which corresponds to 95 th percentile of RDW for the reference population in the National Health and Nutrition Examination Survey IIII study. [55] Recently there have been numerous reports speculating about the role of RDW in predicting morbidity and mortality in heart failure patients. [56; 57] According to Tonelli et al [57] elevated RDW indicates the presence of underlying chronic inflammation which is associated with increased risk of cardiovascular failure.…”

Section: Rbc Morphologymentioning

confidence: 99%

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Red blood cells in retinal vascular disorders

Agrawal

Sherwood

Chhablani

et al. 2016

Blood Cells, Molecules, and Diseases

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Microvascular circulation plays a vital role in regulating physiological functions, such as vascular resistance, and maintaining organ health. Pathologies such as hypertension, diabetes, or hematologic diseases affect the microcirculation posing a significant risk to human health. The retinal vasculature provides a unique window for non-invasive visualisation of the human circulation in vivo and retinal vascular image analysis has been established to predict the development of both clinical and subclinical cardiovascular, metabolic, renal and retinal disease in epidemiologic studies. Blood viscosity which was otherwise thought to play a negligible role in determining blood flow based on Poiseuille's law up to the 1970s has now been shown to play an equally if not a more important role in controlling microcirculation and quantifying blood flow. Understanding the hemodynamics/rheology of the microcirculation and its changes in diseased states remains a challenging task; this is due to the particulate nature of blood, the mechanical properties of the cells (such as deformability and aggregability) and the complex architecture of the microvasculature. In our review, we have tried to postulate a possible role of red blood cell (RBC) biomechanical properties and laid down future framework for research related to hemorrheological aspects of blood in patients with retinal vascular disorders

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The red blood cell distribution width

Cited by 316 publications

References 14 publications

Association between red blood cell distribution width and macrovascular and microvascular complications in diabetes

Association between red blood cell distribution width and macrovascular and microvascular complications in diabetes

Correlation between red cell distribution width and grade of hepatic steatosis and liver enzymes in patients with Non-Alcoholic steatohepatitis

Red blood cells in retinal vascular disorders

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