The Recurrence of Cervical Precancerous Lesion Among HIV Positive and Negative Ethiopian Women After Cryotherapy: A Retrospective Cohort Study

Abstract

Background Early testing and treatment is among the successful strategies for the prevention and control of cervical precancerous and invasive cancer, and a paramount for women with HIV. In Ethiopia, visual inspection with acetic acid for screening and cryotherapy treatment is commonly practiced, though the recurrence of the precancerous lesion after treatment has not been well documented. Objective This study was aimed to estimate the association of HIV status and the recurrence of cervical precancerous lesion after cryotherapy among Ethiopian women. Methods We conducted a retrospective cohort study from January to April 2021. The time to the incidence of recurrence was compared between HIV positive and HIV negative women. Cox regression models were used to adjust the analyses for potential confounders, and only women treated with cryotherapy after a positive Visual Inspection with Acetic acid (VIA) screening test were included. Results A total of 140 eligible patient cards were included in the analysis with the median follow-up of 15.5 months. The overall recurrence rate was 15.7% (22/140), with a greater proportion among HIV negative women, 19.0% (4/21) than HIV positive 15.1% (18/119). Prolonged use of corticosteroid and higher age were the major significant predictors of a higher likelihood of recurrence. The recurrence of screening positive lesion was higher among women aged above 39 years (hazard ratio (HR) of 11.94 (95% CI, 1.07-133.04; P = .04), and women with prolonged use of corticosteroid (HR = 7.82, 95% CI = 1.04-58.75; P = .046) than their counterparts. Conclusion The recurrence of cervical precancerous lesion after cryotherapy was higher than the expert panel report by WHO with a higher proportion among women of old age and prolonged corticosteroid use. Cryotherapy showed a satisfying performance against the recurrence of cervical disease diagnosed through VIA. To substantiate, our findings, further prospective cohort study is also recommended.

Faktor Risiko Kekambuhan Lesi Prakanker Serviks Pasca Pengobatan Tinjauan Literatur

“…(Zeng et al, 2022) ✓ Multiple HR-HPV infection (OR=1,8; 95% CI=1,1-2,9; P < 0,014). 16 Kulkarni (Bogale et al, 2022) • Recurrence rate sebesar 15,7%.…”

“…Hal tersebut didasari atas fakta bahwa lesi prakanker serviks yang telah ditangani dapat muncul kembali atau disebut dengan kekambuhan. Berdasarkan keseluruhan literatur yang ditinjau, diketahui bahwa tingkat kekambuhan atau recurrence rate lesi prakanker serviks berkisar antara 6,1% hingga 21,69% (Alder et al, 2020;Belkić et al, 2022;Bittencourt et al, 2023;Bogale et al, 2022;Ding et al, 2023;Ge et al, 2021;Kulkarni et al, 2023;Pambinkavil et al, 2023;Zeng et al, 2022). Lebih dari 50% kekambuhan terjadi kurang dari dua tahun pasca pengobatan lesi prakanker serviks (Fernández-Montolí et al, 2020).…”