The recovery of the microbial community after plaque removal depends on periodontal health status

Li, Xiaoqing; Yu, Cheng; Zhang, Bing; Shan, Xiaogang; Mao, Wenjun; Zhang, Zicheng; Wang, Chunyan; Jin, Xiaoxia; Wang, Jinfeng; Zhao, Hui

doi:10.1038/s41522-023-00441-0

Cited by 6 publications

(2 citation statements)

References 62 publications

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“…Tailoring implant treatment based on individual microbiota profiles and immune responses could become a frontier in implant dentistry. Additionally, the findings of this study hold significant implications for clinical practice, guiding dental professionals in managing implant treatments more effectively [153].…”

Section: Discussionmentioning

confidence: 84%

How Can Imbalance in Oral Microbiota and Immune Response Lead to Dental Implant Problems?

Rahnama-Hezavah,

Mertowska,

Mertowski

et al. 2023

IJMS

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Dental implantology is one of the most dynamically developing fields of dentistry, which, despite developing clinical knowledge and new technologies, is still associated with many complications that may lead to the loss of the implant or the development of the disease, including peri-implantitis. One of the reasons for this condition may be the fact that dental implants cannot yield a proper osseointegration process due to the development of oral microbiota dysbiosis and the accompanying inflammation caused by immunological imbalance. This study aims to present current knowledge as to the impact of oral microflora dysbiosis and deregulation of the immune system on the course of failures observed in dental implantology. Evidence points to a strong correlation between these biological disturbances and implant complications, often stemming from improper osseointegration, pathogenic biofilms on implants, as well as an exacerbated inflammatory response. Technological enhancements in implant design may mitigate pathogen colonization and inflammation, underscoring implant success rates.

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Section: Discussionmentioning

confidence: 84%

How Can Imbalance in Oral Microbiota and Immune Response Lead to Dental Implant Problems?

Rahnama-Hezavah,

Mertowska,

Mertowski

et al. 2023

IJMS

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“…37 While traditional research centered on periodontal disease pathogens such as Porphyromonas gingivalis and Treponema denticola, recent studies have underscored the importance of nontraditional periodontal pathogens. 38 Following basic periodontal treatment, Streptococcus and Lactobacilli commonly reestablish the early oral biofilm, 39 with S. gordonii notably emerging as an early colonizer. Upon specific adhesive−receptor interactions, dental plaque begins forming on surfaces within a mere 4 h of exposure to the oral environment.…”

Section: Polishing Efficiency Of Hap−fecr Microspheresmentioning

confidence: 99%

Magnetic Hydroxyapatite-Coated Iron–Chromium Microspheres for Dental Surface Polishing and Plaque Removal

Jiang,

Sun,

et al. 2024

ACS Appl. Mater. Interfaces

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This research aimed to engineer magnetic hydroxyapatitecoated iron−chromium (HAp−FeCr) microspheres to enhance dental surface polishing and plaque elimination. Utilizing a tailored sol−gel approach, the HAp−FeCr microspheres were synthesized and exhaustively characterized via scanning electron microscopy, energy-dispersive X-ray spectroscopy, ζpotential, X-ray diffractometry, and X-ray photoelectron spectroscopy methodologies. Key findings showcased that these microspheres retained their magnetic properties post-HAp coating, as evidenced by the magnetization curves. An innovative magnetic polishing system was developed, incorporating these microspheres and a 2000 rpm magnet. Comparative evaluations between traditional air-powder polishing and the proposed magnetic technique demonstrated the latter's superiority. Notably, the magnetic polishing led to a substantial reduction in dental plaque on the tooth surface, decreasing bacterial adhesion and early biofilm formation by Streptococcus gordonii and Lactobacillus acidophilus, where the most pronounced effects were observed in samples with elevated HAp content. A significant 60% reduction in dental plaque was achieved with the magnetic method relative to air-powder polishing. Furthermore, the HAp−FeCr microspheres' biocompatibility was verified through cytotoxicity tests and animal studies. In essence, the magnetic HAp−FeCr microspheres present a novel and efficient strategy for dental treatments, holding immense potential for improving oral health.

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The association between periodontal microbial biomarkers and primary therapy outcome

Werner,

Frasheri,

Heck

et al. 2024

Clin Oral Invest

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Objective This study aims to analyse the association between the baseline microbial load of selected periodontopathogenic bacteria collected from gingival crevicular fluid (GCF) and the primary outcome of steps I and II therapy. Materials and methods 222 patients with stage III periodontitis were included into this retrospective analysis that received steps 1 and 2 periodontal therapy without adjunctive systemic antibiotics. Baseline GCF samples were quantitatively analysed using ELISA-based kits for levels of periodontopathogens (Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans (Aa), Prevotella intermedia (Pi), Fusobacterium nucleatum (Fn), Treponema denticola (Td), and Tannerella forsythia (Tf)) and associated with the primary therapy outcome using a “treat-to-target” therapy endpoint (TE) defined as ≤ 4 sites with PD ≥ 5 mm six months after therapy. Results 38.2% of the patients achieved TE. Patients failing to achieve TE revealed significantly increased levels of Pg, Fn, and Tf at baseline (Pg: p = 0.010, Fn: p = 0.008 Tf: p = 0.004). Multivariate binary logistic regression adjusted for sex, mean probing depth, diabetes, and current smoking status showed an independent relationship between Tf and the TE (aOR 2.570, p = 0.023). Conclusion Increased microbial load is associated with decreased responsiveness to therapy. The findings suggest that specifically baseline Tf levels are associated with poorer treatment outcomes and might improve the accuracy of periodontal diagnosis. Clinical relevance The findings of this study support the concept of a critical biomass that is sufficient to induce and maintain an immune response within the periodontal pocket, which ultimately leads to irreversible tissue destruction. However, calculating this level in advance may serve as an early indicator for intervention. Key finding Baseline Tannerella forsythia levels are associated with poorer treatment outcome.

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The recovery of the microbial community after plaque removal depends on periodontal health status

Cited by 6 publications

References 62 publications

How Can Imbalance in Oral Microbiota and Immune Response Lead to Dental Implant Problems?

How Can Imbalance in Oral Microbiota and Immune Response Lead to Dental Implant Problems?

Magnetic Hydroxyapatite-Coated Iron–Chromium Microspheres for Dental Surface Polishing and Plaque Removal

The association between periodontal microbial biomarkers and primary therapy outcome

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