The recovery of long-term denervated rat muscles after Marcaine treatment and grafting

Billington, Lynn; Carlson, Bruce M.

doi:10.1016/s0022-510x(96)00219-5

Cited by 20 publications

(17 citation statements)

References 42 publications

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“…19 Hypertrophy also occurs after injection of denervated muscle in animals, auguring well for therapeutic trials in paretic strabismus. 20 Accurate measurement of eye muscle sizes, forces and changes in alignment are under way in animals and humans in order to define the optimum volume of injection, drug dosage and location in the muscle for injection. It has not escaped our notice that extension of this approach to other muscles holds much promise.…”

Section: Discussionmentioning

confidence: 99%

Bupivacaine injection of eye muscles to treat strabismus

Scott

Alexander

Miller

2007

British Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 99%

Bupivacaine injection of eye muscles to treat strabismus

Scott

Alexander

Miller

2007

British Journal of Ophthalmology

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“…Scott et al[5] reported a 6.2% increase in volume of the rectus muscle and changes of 6 PD when BUP was injected into the rectus muscle of an esotropic patient. Denervated muscle hypertrophy also occurs after bupivacain injection in animals, arguing for therapeutic trial in paretic strabismus [6]. However, in our subject, there were subtle increases in volume.…”

Section: Discussionmentioning

confidence: 76%

Bupivacaine Injection to Lateral Rectus in Abducens Nerve Palsy

Kyung

Jeon

2013

Korean J Ophthalmol

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A 49-year-old female presented with bilateral abducens nerve palsies. She had 75 prism diopter esotropia. The extraocular movement of the lateral rectus was -1 limitation for the right eye and -4 limitations for the left. After performing orbital magnetic resonance imaging (MRI), 2 mL of bupivacain (5 mg/mL) was injected into the left lateral rectus (LR). One month after injection, a further orbital MRI was performed. Subsequently, recession of both medial rectus (6 mm) and resection of the left LR (9 mm) were performed. After one month, bupivacaine had no hypertrophic effects. There was little change in angle of deviation. The orbital MRI scan showed a 1.91% increase in volume compared to the muscle prior to the injection. Histological findings showed no muscle fibers of the left LR muscle, only the fiber nucleus and the collagen that replaced the fibers. We report on the changes in stiffness and muscle volume and on the histology of the muscle one month after injecting bupivacaine into the paralyzed left LR muscle combined with standard surgical treatment.

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“…These regenerative processes frequently result in the development of abnormal muscle cells that branch or form small clusters surrounded by two layers of basal lamina (the old and the new one, which is secreted by the new myofiber) [29,38,39]. Spontaneous myofiber regeneration in long-term denervation has been quantified and shown to be non-compensatory and to result in the reduction of satellite cell pools [29, [40][41][42][43][44][45][46][47]. The turnover of myonuclei (but not necessarily of regenerating myofibers), studied by means of continuous infusion of 5-bromo-2-deoxyuridine (BRDU), occurs at most 1 to 2% per week in adult rats [45,48].…”

Section: Myogenesis and Regeneration Of Myofibers In Denervated Skelementioning

confidence: 99%

“…Specifically, in four-month denervated animals, bupivacaine induces massive and synchronous myofiber regeneration within a few days in both fast and slow rat muscles [56,61,62]. When the denervated muscles are treated with marcaine or notexin, autografting of seven-month denervated rat muscles is followed by substitution of old fibers by new fibers [39,40,42,63,64]. The aneurally regenerated myofibers grow within a few days post auto-transplantation and maintain the achieved one fourth of their normal adult fiber sizes for two weeks, then they atrophy and reach a steady-state size at less than one tenth of the normal fiber size [39].…”

Section: Induced Regenerative Myogenesis In Long-term Denervationmentioning

confidence: 99%

Modulation of trophism and fiber type gene expression in denervated muscle activated by different patterns of electrical stimulation. Role of muscle fiber regeneration revisited in 2017

Marcante¹,

Baba²,

Carraro³

et al. 2017

Biol Eng Med

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After sixty and more years of basic research on electrostimulation-induced muscle plasticity, in the last fifteen years a few studies have employed long impulse biphasic electrical stimulation as a treatment for human long-term denervated muscle. Tissue trophism and muscle power are improved to a level sufficient to restore some functions by home based Functional Electrical Stimulation (h-bFES). These treatments usually start late after denervation due to clinical constraints. The changes induced by 1) denervation, 2) spontaneous or induced aneural myogenesis, and 3) long-term electrical stimulation starting either early or late after denervation, in both animal models and in clinic, are here reported once again to attract attention of patients, physiatrists and physiotherapists on achievable results and on limitations of h-bFES for denervated degenerating muscles (DDM). The trophic and functional recovery from severe atrophy/degeneration of long-term denervated muscle by h-bFES of DDM is a fact standing on a sound foundation. Furthermore, a new muscle quantitative color computed tomography (MQC-CT) adds, to functional evidence and to muscle biopsy analyses, the results based on tridimensional analysis of a full skeletal muscle. The differentiation of muscle fibers regenerating in the absence of the nerve is remarkable in animal experiments. If myogenesis in patients could be modulated during the months needed to recover denervated muscle tetanic contractility, it should be possible to substantially abbreviate the time needed to achieve functional recovery of long term denervated human muscle by h-bFES of DDM using the commercial muscle stimulator and the large electrodes now available.

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The recovery of long-term denervated rat muscles after Marcaine treatment and grafting

Cited by 20 publications

References 42 publications

Bupivacaine injection of eye muscles to treat strabismus

Bupivacaine injection of eye muscles to treat strabismus

Bupivacaine Injection to Lateral Rectus in Abducens Nerve Palsy

Modulation of trophism and fiber type gene expression in denervated muscle activated by different patterns of electrical stimulation. Role of muscle fiber regeneration revisited in 2017

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