The recognition and estimation of cyclic trends

Edwards, Jeff

doi:10.1111/j.1469-1809.1961.tb01501.x

Cited by 402 publications

(213 citation statements)

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“…Seasonal variation in incidence was assessed using the Edwards test for seasonality [20] with an adjustment for variable month length. A p-value of less than 0.05 was considered statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Space–time clustering of elevated thyroid stimulating hormone levels

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Space–time clustering of elevated thyroid stimulating hormone levels

et al. 2011

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“…We compared the seasonal distribution of hospitalization for pneumonia in patients with and without exposure to antidepressants using the method of Edwards [11]. This sums the vectors for the number of cases in each month extending from a common origin to the midpoints of twelve equal sectors of a circle from January (0 to 30°) through December (330 to 360°).…”

Section: Discussionmentioning

confidence: 99%

Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measures

Hennessy¹,

Bilker²,

Leonard³

et al. 2007

Journal of Clinical Epidemiology

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Objective-A prior study suggested that antidepressants might increase the risk of hospitalization for pneumonia in the elderly. This study sought to confirm or refute this hypothesis.Study Design and Setting-Case-control study of persons age 65 and above nested in the UK General Practice Research Database.Results-We identified 12,044 cases of the hospitalization for pneumonia (the primary outcome) and 48,176 controls. The odds ratio (OR) for any antidepressant use, adjusting for age, sex, and calendar year was 1.61 (95% confidence interval 1.46 to 1.78). After further adjustment for comorbidity measures, the OR was 0.89 (0.79 to 1.00). We also identified 159 cases of hospitalization for aspiration pneumonia (the secondary outcome) and 636 controls. The OR for any antidepressant use, adjusted for age, sex, and calendar year was 1.45 (0.65 to 3.24). After further adjustment for comorbidity measures, the OR was 0.63 (0.23 to 1.71).Conclusion-These findings refute the prior hypothesis that use of antidepressants by elderly patients increases the risk of hospitalization for pneumonia or for aspiration pneumonia. Decisions regarding use of antidepressants in elderly persons should not be affected by concern about pneumonia risk. Data-derived hypotheses should be independently confirmed before being acted upon.

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“…Multiple logistic regression analysis was used to compare clinical symptoms by stratified age groups with adjustment for possible confounding. The Edwards test, which fits a sine curve to monthly incidence data, was used to assess the epidemic pattern of measles [10]. Measles VE was calculated by the screening method [11].…”

Section: Methodsmentioning

confidence: 99%

Epidemiology of measles in Blantyre, Malawi: analyses of passive surveillance data from 1996 to 1998

et al. 2002

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SUMMARYMeasles surveillance data in Blantyre, Malawi were reviewed for 1996-8 to describe the epidemiology of infection and to estimate vaccine efficacy (VE) by the screening method. A total of 674 measles cases were reported to the Blantyre District Health Office during this period. Age distribution showed that 108 (16n1 %) of the cases were aged less than 1 year. The median age was 5 years. Eighty percent of the cases between 1 and 19 years had been previously vaccinated. VE was 68n6 % (95 % CI, 52n7-79n2) for children 12-23 months of age and 67n3 % (95 % CI, 48n3-79n3) for infants 9-11 months of age. Reasons for this low vaccine efficacy are discussed. Previous vaccination history was negatively associated with the risk for developing cough during measles infection (odds ratio (OR), 0n30 ; 95 % CI, 0n09-0n91), diarrhoea (OR, 0n64 ; CI, 0n44-0n95) and pneumonia (OR, 0n40 ; CI, 0n25-0n62). Logistic regression analysis showed that pneumonia in adults was negatively associated with vaccination history. The passive surveillance system for measles in Malawi was useful to describe the epidemiology of measles.

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The recognition and estimation of cyclic trends

Cited by 402 publications

References 1 publication

Space–time clustering of elevated thyroid stimulating hormone levels

Space–time clustering of elevated thyroid stimulating hormone levels

Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measures

Epidemiology of measles in Blantyre, Malawi: analyses of passive surveillance data from 1996 to 1998

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