The Recessive model of 677C>T Polymorphism in MTHFR gene increase moderately the risk of Colorectal Cancer in Moroccan patients

Abstract

Methylenetetrahydrofolate reductase (MTHFR) is a critical folate-metabolising enzyme and a polymorphism at position 677 (C677T), is associated with reduced enzyme activity. We investigated whether this functional polymorphism modulates the risk of developing Colorectal Cancer (CRC).We conducted a hospital-based case-control study to assess the association of MTHFR gene polymorphism C677T with risk for colorectal cancer in a Moroccan population. Odds ratios [ORs] with corresponding 95 % confidence intervals (Cis) were used to assess the association.The analysis had shown the significant elevated risk of cancer was associated with theMTHFR C677T polymorphism in recessive model (OR = 2.81, 95 % CI; (1.13-7.06), P=0.027) compared the other genetic models. Simultaneously, the T-allele genotype versus C-allele genotype was not associated with CRC risk (OR a = 1.355; 95% CI = 0.94-1.96and p = 0.10).Thusrecessive model are significantly associated in the risk of colorectal cancer. Further larger-scale studies are necessary to confirm our finding.