The receptor tyrosine kinase gene linotte is required for neuronal pathway selection in the Drosophila mushroom bodies

Moreau-Fauvarque, Caroline; Taillebourg, Emmanuel; Boissoneau, Elisabeth; Mesnard, Jacqueline; Dura, Jean-Maurice

doi:10.1016/s0925-4773(98)00147-6

Cited by 60 publications

(47 citation statements)

References 31 publications

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“…We screened 30 GAL4 drivers for expression in larval MB KCs (O'Dell et al, 1995;Yang et al, 1995;Connolly et al, 1996;Koushika et al, 1996;Amrein and Axel, 1997;Tettamanti et al, 1997;Kraft et al, 1998;Moreau-Fauvarque et al, 1998;McBride et al, 1999;Hayashi et al, 2002;Manoli et al, 2005;Keleman et al, 2007;Krashes et al, 2007;Tanaka et al, 2008). In addition, we screened another 64 GAL4 drivers (Tanaka et al, 2008) for expression in non-KC MBINs or in MBENs.…”

Section: Methodsmentioning

confidence: 99%

DrosophilaLarvae Establish Appetitive Olfactory Memories via Mushroom Body Neurons of Embryonic Origin

et al. 2010

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Insect mushroom bodies are required for diverse behavioral functions, including odor learning and memory. Using the numerically simple olfactory pathway of the Drosophila melanogaster larva, we provide evidence that the formation of appetitive olfactory associations relies on embryonic-born intrinsic mushroom body neurons (Kenyon cells). The participation of larval-born Kenyon cells, i.e., neurons that become gradually integrated in the developing mushroom body during larval life, in this task is unlikely. These data provide important insights into how a small set of identified Kenyon cells can store and integrate olfactory information in a developing brain. To investigate possible functional subdivisions of the larval mushroom body, we anatomically disentangle its input and output neurons at the single-cell level. Based on this approach, we define 10 subdomains of the larval mushroom body that may be implicated in mediating specific interactions between the olfactory pathway, modulatory neurons, and neuronal output.

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Section: Methodsmentioning

confidence: 99%

DrosophilaLarvae Establish Appetitive Olfactory Memories via Mushroom Body Neurons of Embryonic Origin

et al. 2010

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“…Although several mutants with MB midline crossing defects have been described (Boquet et al, 2000b;Moreau-Fauvarque et al, 1998;Simon et al, 1998), a detailed time-course that could distinguish pathfinding defects from later onset defects has been reported only for fmr1 mutants, defective in the Drosophila homolog of the fragile X mental retardation gene (Michel et al, 2004). In fmr1 mutants, ␣/␤ axons extend branches across the midline by 24 hours PPF and medial lobe fusion appears complete by 48 hours PPF, consistent with a defect in initial outgrowth (Michel et al, 2004).…”

Section: Ptpmeg Stabilizes Mushroom Body Dorsal Lobe Axons By Preventmentioning

confidence: 99%

Ptpmeg is required for the proper establishment and maintenance of axon projections in the central brain ofDrosophila

et al. 2007

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Ptpmeg is a cytoplasmic tyrosine phosphatase containing FERM and PDZ domains. Drosophila Ptpmeg and its vertebrate homologs PTPN3 and PTPN4 are expressed in the nervous system, but their developmental functions have been unknown. We found that ptpmeg is involved in neuronal circuit formation in the Drosophila central brain, regulating both the establishment and the stabilization of axonal projection patterns. In ptpmeg mutants, mushroom body (MB) axon branches are elaborated normally, but the projection patterns in many hemispheres become progressively abnormal as the animals reach adulthood. The two branches of MB ␣/␤ neurons are affected by ptpmeg in different ways; ptpmeg activity inhibits ␣ lobe branch retraction while preventing ␤ lobe branch overextension. The phosphatase activity of Ptpmeg is essential for both ␣ and ␤ lobe formation, but the FERM domain is required only for preventing ␣ lobe retraction, suggesting that Ptpmeg has distinct roles in regulating the formation of ␣ and ␤ lobes. ptpmeg is also important for the formation of the ellipsoid body (EB), where it influences the pathfinding of EB axons. ptpmeg function in neurons is sufficient to support normal wiring of both the EB and MB. However, ptpmeg does not act in either MB or EB neurons, implicating ptpmeg in the regulation of cell-cell signaling events that control the behavior of these axons.

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“…First, prevention of mushroom body development results in poor courtship conditioning memory [McBride et al, 1999]. Second, the Drosophila memory mutant linotte has the same mushroom body phenotype [Moreau-Fauvarque et al, 1998]. Third, the ␣/␤ lobes are required for memory retrieval [McGuire et al, 2001].…”

Section: Case In Point: Drosophila Fragile X Mental Retardation 1 (Dfmentioning

confidence: 99%

Mental retardation genes in drosophila: New approaches to understanding and treating developmental brain disorders

Restifo

2005

Ment. Retard. Dev. Disabil. Res. Rev.

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Drosophila melanogaster is emerging as a valuable genetic model system for the study of mental retardation (MR). MR genes are remarkably similar between humans and fruit flies. Cognitive behavioral assays can detect reductions in learning and memory in flies with mutations in MR genes. Neuroanatomical methods, including some at single-neuron resolution, are helping to reveal the cellular bases of faulty brain development caused by MR gene mutations. Drosophila fragile X mental retardation 1 (dfmr1) is the fly counterpart of the human gene whose malfunction causes fragile X syndrome. Research on the fly gene is leading the field in molecular mechanisms of the gene product's biological function and in pharmacological rescue of brain and behavioral phenotypes. Future work holds the promise of using genetic pathway analysis and primary neuronal culture methods in Drosophila as tools for drug discovery for a wide range of MR and related disorders.

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The receptor tyrosine kinase gene linotte is required for neuronal pathway selection in the Drosophila mushroom bodies

Cited by 60 publications

References 31 publications

DrosophilaLarvae Establish Appetitive Olfactory Memories via Mushroom Body Neurons of Embryonic Origin

DrosophilaLarvae Establish Appetitive Olfactory Memories via Mushroom Body Neurons of Embryonic Origin

Ptpmeg is required for the proper establishment and maintenance of axon projections in the central brain ofDrosophila

Mental retardation genes in drosophila: New approaches to understanding and treating developmental brain disorders

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