The Receptor For Advanced Glycation End-Products Is A Central Mediator Of Asthma Pathogenesis

Milutinovic, Pavle S.; Alcorn, John F.; Englert, Judson M.; Crum, Lauren T.; Oury, Tim D.

doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4294

Cited by 22 publications

(43 citation statements)

References 37 publications

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“…Similar results have been reported in a study by Milutinovic et al [52]. They found that the RAGE mRNA and protein levels in the lungs appear unchanged after the mice were immunized with OVA or house dust mite extracts.…”

Section: Discussionsupporting

confidence: 91%

“…Mice were given an aerosol challenge of 5 mL 4% OVA in PBS once a day, 5 days per week, for 4 weeks. On days 29,31,33,36,38,40,43,45,47,50,52, and 54, mice were given an intratracheal instillation of PBS (OVA group), with or without anti-HMGB1 neutralizing antibody (30 mg/mouse; OVA + anti-HMGB1 Ab group), or a control rabbit IgG antibody (Jackson ImmunoResearch Laboratories Inc., West Grove, PA, USA) (30 mg/mouse; OVA + isotype control Ab group) 1 h before OVA exposure. There were 8-10 mice per group.…”

Section: Animals and Experimental Protocolmentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of high-mobility group box 1 in lung reduced airway inflammation and remodeling in a mouse model of chronic asthma

Lee

Lai

Chang

et al. 2013

Biochemical Pharmacology

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Section: Discussionsupporting

confidence: 91%

Section: Animals and Experimental Protocolmentioning

confidence: 99%

Inhibition of high-mobility group box 1 in lung reduced airway inflammation and remodeling in a mouse model of chronic asthma

Lee

Lai

Chang

et al. 2013

Biochemical Pharmacology

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“…The present study is the first one we know of to link intake of HFCS-sweetened beverages and AJ -beverages with relatively high levels of EFF -with asthma in young children. Results are consistent with anecdotal evidence linking HFCS with asthma (8) and with research indicating that RAGE is a central mediator of asthma (9) . Although other interpretations are possible, these analyses support the mechanistic hypothesis that enFruAGE -ligands of RAGE that are generated locally within the intestinal lumen following excessive intake of EFF beverages -may play a role in the pathogenesis of asthma in young children.…”

Section: Discussionsupporting

confidence: 89%

“…In situ intestinal formation of advanced glycation end products (enFruAGE) arising from high intake of excess free fructose (EFF) has been suggested as a possible mechanism for EFF-associated childhood asthma (8) . Recently, an important role for the receptor of advanced glycation end products (RAGE) in mediating asthma has been suggested (9) . This supports the possibility that advanced glycation end products (AGE) -known ligands of RAGE -might contribute to asthma pathogenesis.…”

mentioning

confidence: 99%

Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2–9 years

DeChristopher

Uribarri

Tucker

2015

Public Health Nutr.

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Objective: High soft drink consumption has been linked with asthma. Anecdotal evidence links high-fructose corn syrup with asthma. The receptor of advanced glycation end products (RAGE) has emerged as a mediator of asthma. The objectives of the present study were to: (i) assess the correlation between intake of beverages containing excess free fructose (EFF beverages) and asthma in children; and (ii) epidemiologically test the mechanistic hypothesis that intake of high EFF beverages, such as apple juice or beverages sweetened with high-fructose corn syrup, is associated with increased risk of asthma. This hypothesis is based on the possible effect of increases in the in situ intestinal formation of advanced glycation end products (enFruAGE) with EFF, which may be absorbed and play a role in RAGE-mediated asthma. Design: We examined cross-sectional associations between beverage intake and self-reported current or history of asthma. Exposure variables were EFF beverages, including apple juice (AJ), non-diet soft drinks (ndSD) and fruit drinks (FD). Orange juice (OJ), not an EFF beverage, was included as a comparison. Rao-Scott χ 2 analysis was used for prevalence differences and logistic regression for associations, adjusted for age, sex, race/ethnicity, BMI and total energy intake. Setting: Data are from the National Health and Nutrition Examination Survey 2003-2006, a nationally representative survey. Subjects: US children (n 1961) aged 2-9 years with complete responses on the dietary frequency questionnaire. Results: Intakes of EFF beverages were significantly associated with asthma in 2-9-year-olds. Adjusted odds of asthma in children consuming EFF beverages ≥5 times/week was more than five times that in children consuming these beverages ≤1 time/month (OR = 5·29, P = 0·012). Children consuming AJ ≥5 times/week v. ≤1 time/month, adjusted for the other beverages, were more than twice as likely to have asthma (OR = 2·43, P = 0·035). In contrast, there was a tendency for OJ to be protective. Conclusions: These results support the hypothesis that intake of high EFF beverages, including AJ and beverages sweetened with high-fructose corn syrup, is associated with asthma in children aged 2-9 years. Results support the mechanistic hypothesis that enFruAGE may be an overlooked contributor to asthma in children. Longitudinal studies are needed to provide evidence of causal association.

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“…In 2003-2006 [the NHANES study period], high fructose corn syrup was the main sweetener in US soft drinks [31]. Odds ratios were considered statistically significant if the 95% confidence intervals did not include 1 and p values were <0.05, as indicated by italics accumulate in the pancreas and contribute to pancreatitis and impaired ß-cell function; [58,59] AGE are elevated in connective tissues including the synovium, sub-lining, and cartilage of autoimmune arthritis sufferers [71][72][73][74][75]; and the receptor of advanced glycation end-products (RAGE) is a key mediator of asthma [76].…”

Section: Discussionmentioning

confidence: 99%

Intake of high fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent coronary heart disease, in U.S. adults, ages 45–59 y

2017

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Background: Intake of high excess free fructose (EFF) beverages, including high fructose corn syrup (HFCS), sweetened soft drinks, fruit drinks, and apple juice, may be associated with childhood asthma, adult idiopathic chronic bronchitis/ COPD, and autoimmune arthritis, possibly due to underlying fructose malabsorption. Fructose malabsorption may contribute to the intestinal in situ formation of advanced glycation end-products (enFruAGEs) that travel to other tissues and promote inflammation. Chronic respiratory conditions and arthritis are comorbidities of coronary heart disease (CHD). The objective of this study was to investigate the association between intake of high EFF beverages and CHD. Methods: In this cross sectional study (NHANES 2003(NHANES -2006 of adults, aged 45-59 y, n = 1230, the exposure variables were non-diet soft drinks, and any combination of high EFF beverages including non-diet soft drinks, fruit drinks, and apple juice. Analyses of diet soft drinks, diet fruit drinks, and orange juice (non/low EFF beverages) were included for comparison. The outcome was self-reported history of coronary heart disease and/or angina (CHD). Rao Scott Ҳ 2 was used for prevalence differences and logistic regression for associations, adjusted for age, sex, raceethnicity, BMI, socio-economic status, health insurance coverage, smoking, physical activity level, hypertension, energy intake, fruit and vegetable intake, glycated hemoglobin, pre-diabetes, and diabetes.Results: Intake of any combination of HFCS sweetened soft drinks, fruit drinks, and apple juice (tEFF) was significantly associated with CHD in adults aged 45-59 y. Adults consuming tEFF ≥5 times/wk. were 2.8 times more likely to report CHD than ≤3 times/mo consumers (OR 2.82; 95% CI 1.16-6.84; P = 0.023), independent of all covariates.Conclusion: HFCS sweetened soft drinks, fruit drinks, and apple juice may contribute to CHD, a common comorbidity of chronic respiratory conditions and autoimmune arthritis, possibly due to the high ratio of fructose to glucose in these beverages. Underlying fructose malabsorption may contribute to the intestinal in situ formation of pro-inflammatory enFruAGEs, that are eventually absorbed and induce inflammation of the coronary arteries. Additional research is needed.

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The Receptor For Advanced Glycation End-Products Is A Central Mediator Of Asthma Pathogenesis

Cited by 22 publications

References 37 publications

Inhibition of high-mobility group box 1 in lung reduced airway inflammation and remodeling in a mouse model of chronic asthma

Inhibition of high-mobility group box 1 in lung reduced airway inflammation and remodeling in a mouse model of chronic asthma

Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2–9 years

Intake of high fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent coronary heart disease, in U.S. adults, ages 45–59 y

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