The Recent Impact of Solid‐Phase Synthesis on Medicinally Relevant Benzoannelated Oxygen Heterocycles

Ziegert, Robert E.; Toraeng, Jakob; Knepper, Kerstin; Braese, Stefan

doi:10.1002/chin.200528262

Cited by 4 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Annulated heterocyclic systems have a variety of pharmacological uses, [1,2] which provides incentive to synthetic organic chemists to devise novel yet simple strategies for the generation of these molecular frameworks. The development of isoxazole-annulated ring systems has been a topic of continuous research due to the synthetic and medicinal importance of such scaffolds.…”

Section: Introductionmentioning

confidence: 99%

A General Approach to the Synthesis of Substituted Isoxazolo[4,3‐c]quinolines via Chalcones

et al. 2007

View full text Add to dashboard Cite

A general and practical approach to the synthesis of substituted isoxazolo [4,3-c]quinolines from the substituted isoxazolines obtained by 1,3-dipolar cycloadditions between 2-nitrobenzonitrile oxide and chalcones is described. SnCl 2 ·2H 2 O-mediated reduction of the nitro group, followed by intramolecular cyclization involving the amino and the keto groups in these substrates, furnished mixtures of

show abstract

Section: Introductionmentioning

confidence: 99%

A General Approach to the Synthesis of Substituted Isoxazolo[4,3‐c]quinolines via Chalcones

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Fused heterocycles are reported to show a wide variety of applications in medicinal chemistry . Despite several reports on the synthesis of fused heterocycles, there is a continuing demand for development of new methods for the synthesis of novel fused heterocycles because of their plethora of medicinal applications .…”

Section: Introductionmentioning

confidence: 99%

A Convenient and Facile Hantzsch Synthesis of Aryl Imidazo[1,2‐b]Isoxazolyl‐N‐aryl Thiazol Amines

Rajanarendar

Thirupathaiah

Ramakrishna

et al. 2015

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

The Hantzsch synthesis of novel aryl imidazo[1,2‐b]isoxazolyl‐N‐aryl thiazol amines 5 analogues were described. Reaction of 3‐aminoisoxazole 1 with substituted phenacyl bromides 2 in dry ethanol afforded the corresponding 6‐methyl‐3‐arylimidazo[1,2‐b]isoxazoles 3 in good yields. Compounds 3 on reaction with chloroacetyl chloride in 1,4‐dioxane furnished the corresponding 2‐chloro‐1‐(6‐methyl‐3‐arylimidazo[1,2‐b]isoxazol‐2‐yl)ethanones 4. Compounds 4 on heating with N‐aryl thioureas in an oil bath underwent cyclization to afford the title compounds viz., imidazo[1,2‐b]isoxazolyl‐N‐aryl thiazol amines 5 in moderate to good yields by Hantzsch synthesis.

show abstract

“…148,151 In addition to the citations found in Tables 1-13, publications appeared on new tagging methodologies, 378,379 color-facilitated assays for screening 380 and functional group detection, 381 ladder synthesis of "one-bead one-compound" libraries, 382 synthesis on sequentially linked columns, 383 resin distribution tools, 384 ROMPgel beads for use in IRORI Kan format, 385 resin-supported chain transfer agents, 386 TLC-MALDI MS analysis of nonpeptide libraries, 387 and HT purification of single compounds and libraries. 388 Reviews published in 2005 include topics on compound libraries and chemical genomics, 389 Kenner's safety-catch linkers, 390 1,3-dipolar additions on solid-phase, 391 sulfide-and selenide-based linkers in phase tag-assisted synthesis, 392 benzoannelated oxygen heterocycles, 393 and convergent approaches to library synthesis. 394 Caspase-3 Inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Survey of Combinatorial Library Synthesis: 2005

et al. 2006

View full text Add to dashboard Cite

An exhaustive compilation of biologically active libraries covering the years 1992-1997 was presented in a previous review [1a]. In that review, libraries were divided among 4 major categories, including those active against proteases, non-proteolytic enzymes, Gprotein coupled receptors, and non-G-protein coupled receptors. A generic structure for each library was provided as well as the structure of the most active member. The number of biologically active libraries reported in the literature during this time period (86 total) represents <25% of the total number of published library constructs. Disclosure of library synthesis without accompanying screening data is a more common occurrence. Because these types of libraries are equally important to the practicing combinatorial chemist, it was thought that a comprehensive listing of such libraries spanning the years 1992-1997 would be a useful supplement to the previous review [1a,b].Library constructs [2-248] listed herein are relegated to one of five tables. Table 1 is entitled 'Scaffold derivatization' and includes all constructs in which a multi-functional scaffold is modified in some fashion to create a library. An example of a construct found in Table 1 would be the sequential addition of three nucleophiles to trichloropyrimidine. Table 2, entitled 'Acyclic synthesis', lists all linear constructs such as those derived from multi-component Ugi condensations.

show abstract

The Recent Impact of Solid‐Phase Synthesis on Medicinally Relevant Benzoannelated Oxygen Heterocycles

Abstract: For Abstract see ChemInform Abstract in Full Text.

Cited by 4 publications

References 1 publication

A General Approach to the Synthesis of Substituted Isoxazolo[4,3‐c]quinolines via Chalcones

A General Approach to the Synthesis of Substituted Isoxazolo[4,3‐c]quinolines via Chalcones

A Convenient and Facile Hantzsch Synthesis of Aryl Imidazo[1,2‐b]Isoxazolyl‐N‐aryl Thiazol Amines

Comprehensive Survey of Combinatorial Library Synthesis: 2005

Contact Info

Product

Resources

About