The recent development of thymol derivative as a promising pharmacological scaffold

Abstract

Thymol (a phenol ring bearing active phytoconstituent) is a privileged scaffold, which is diversified in natural sources. This scaffold acts as an obligatory template for scheming and arriving at designing some newer drug‐molecules with potential biological activities. In the pharmacological perspective, the promising active sites of the scaffold are the positions C‐1, C‐4, and C‐6 of thymol that would be accountable for developing potent drug candidates. This review aims to explore the various synthetic routes and the structural‐activity relationship of thymol scaffold with suitable active pharmacophore sites.

Phytocytogenotoxicity of Esters obtained from Phenols and Phenoxyacetic Acid using the Steglich reaction

“…These phenols exhibit diverse biological and pharmacological effects, including anticancer 10 , anti-in ammatory 11 , antibacterial 12 , antifungal 13 , anticholinesterase 14 , insecticidal 15 , and antioxidant activities 16 . Several derivatives of carvacrol and thymol have been synthesized, demonstrating similar or increased activity compared to the original phenols 17,18 .…”