The 'Real-Life' Effectiveness of Easi-Breathe Breath Actuated Inhalers in the Management of Asthma.

Switching patients from other inhaled corticosteroid devices to the Easyhaler®: historical, matched-cohort study of real-life asthma patients

“…In contrast, most randomized controlled clinical trials typically have very strict selection criteria which result in a homogeneous but often poorly representative study population, relatively small numbers of patients, and relatively short data collection periods. 4 – 6 , 35 , 36 By comparing various other ICS devices with the EH, and by retrospectively and remotely examining the outcome of the switch, we documented the results when primary-care physicians switched their asthma patients from another ICS device to the EH, regardless of which device the patient was currently using. In this respect, our study design put the EH to a very challenging test.…”

“… 30 Because they reduce the delivered dose of medication, critical errors compromise asthma control and thus increase the costs of asthma management. 30 As demonstration of correct inhaler technique is typically a prerequisite for inclusion in controlled clinical trials evaluating the efficacy of inhaled medications or comparing different inhalers, 20 , 31 , 35 , 36 the applicability of such trials to asthma patients in real life is limited. In fact, it has been observed that typical asthma patients make many errors – even with their regular inhaler – which may negate the benefits documented in controlled clinical trials.…”