The Reactions to Tetanic Stimulation of the Two‐Neuron Arc in the Kitten

Skoglund, Sten

doi:10.1111/j.1748-1716.1960.tb00178.x

Cited by 34 publications

(9 citation statements)

References 15 publications

(2 reference statements)

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“…In the spinal cord, the synaptic depression elicited at sensorimotor connections in new-born cat is converted to a post-tetanic potentiation in response to the same conditioning stimulation in adults36. Such ADSP conversions have been shown to arise, at least partly, from developmentally regulated changes in NMDAR subunit composition.…”

Section: Discussionmentioning

confidence: 99%

Distinct and developmentally regulated activity-dependent plasticity at descending glutamatergic synapses on flexor and extensor motoneurons

Lenschow¹,

Cazalets²,

Bertrand³

2016

Sci Rep

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Activity-dependent synaptic plasticity (ADSP) is paramount to synaptic processing and maturation. However, identifying the ADSP capabilities of the numerous synapses converging onto spinal motoneurons (MNs) remain elusive. Using spinal cord slices from mice at two developmental stages, 1–4 and 8–12 postnatal days (P1–P4; P8–P12), we found that high-frequency stimulation of presumed reticulospinal neuron axons in the ventrolateral funiculus (VLF) induced either an NMDA receptor-dependent-long-term depression (LTD), a short-term depression (STD) or no synaptic modulation in limb MNs. Our study shows that P1–P4 cervical MNs expressed the same plasticity profiles as P8–P12 lumbar MNs rather than P1–P4 lumbar MNs indicating that ADSP expression at VLF-MN synapses is linked to the rostrocaudal development of spinal motor circuitry. Interestingly, we observed that the ADSP expressed at VLF-MN was related to the functional flexor or extensor MN subtype. Moreover, heterosynaptic plasticity was triggered in MNs by VLF axon tetanisation at neighbouring synapses not directly involved in the plasticity induction. ADSP at VLF-MN synapses specify differential integrative synaptic processing by flexor and extensor MNs and could contribute to the maturation of spinal motor circuits and developmental acquisition of weight-bearing locomotion.

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Section: Discussionmentioning

confidence: 99%

Distinct and developmentally regulated activity-dependent plasticity at descending glutamatergic synapses on flexor and extensor motoneurons

Lenschow¹,

Cazalets²,

Bertrand³

2016

Sci Rep

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“…A delayed development of the discharge from the muscle spindles has actually been found (SKOGLUND 1960 a). In addition there might be a delayed development of the afferent terminals in the spinal cord, for which the results to be described below offer some evidence.…”

mentioning

confidence: 84%

Central Connections and Functions of Muscle Nerves in the Kitten

Skoglund

1960

Acta Physiologica Scandinavica

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In this paper the postnatal development of the afferent terminals of muscle nerves is studied by means of the two‐neuron arc, in kittens from birth to 45 days. The experimental findings support earlier histological evidence for a postnatal development of the dorsal root collaterals of muscle nerves. Evidence is also presented that the afferent terminals in the newborn and young animals have properties different from those in the adult animal. Facilitation is found to be lacking in the newborn animal while inhibition of extensors from flexors has been found extremely potent and longlasting. The results presented throw new light on earlier findings regarding the postnatal development of postural reflexes.

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“…8 But on what anatomical basis this frailty of the rat monosynaptic connection rests remains unsolved (cf. Kaizawa and Takahashi9 …”

Section: Methodsmentioning

confidence: 99%