The Reactions of Compounds with Halogenoimidoyl Groups

Polyfluoroaromatic compounds with a NCClR group—a reactive type of polyfluoroarene

“…N-nucleophilic reagents: primary, secondary, and tertiary amines Transformations with N-nucleophilic reagents, particularly those with amines, are well defined in nonfluorinated imidoyl chlorides [5]. The N-nucleophilic reagents used in reactions with polyfluoroaromatic imidoyl chlorides are primary and secondary aliphatic and aromatic amines as well as tertiary amines.…”

“…Interest in these compounds also arises from the wide spectrum of physiological activity manifested by the compounds themselves or by the products of their transformations. It is not surprising, therefore, that reviews and monographs are devoted to studies of these compounds [1][2][3][4][5][6]. Recently, N-aryl trifluoroacetimidoyl chlorides have become the subject of widespread interest in view of their ability to serve as building blocks in organic synthesis, especially in syntheses of heterocyclic compounds exhibiting physiological activity [7,8].…”

Synthesis of new arylidencycloalkylpyrazoles of potential biological interest

“…Ethyl-1-(4-fluorophenyl)-7-benzyliden-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate (11 General Method for the Synthesis of 1-Aryl-6-aryliden-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic Acid (13).…”

“…With this procedure compounds 7-10 were synthesised. General Method for the Synthesis of Ethyl-1-aryl-7-aryliden-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate (11)(12).…”

C‐Phosphorylated N‐(Trichloroethylidene)sulfonamides: A New Type of Highly Electrophilic Imines

“…The progress of the reaction with water was monitored by 31 P NMR spectroscopy and no signal for the possible intermediate of type 12 was detected. This indicates that the hydrolysis most probably proceeds by the S N 2 mechanism [10] rather than the addition-elimination reaction scheme. Such a difference in the behavior of MeOH and H 2 O can be explained in terms of a stronger mesomeric donor effect of the HO group in relation to MeO (σ p Ϫ0.37 and Ϫ0.27, respectively).…”