The reaction of nitric oxide with ubiquinol: kinetic properties and biological significance

Poderoso, Juan José; Carreras, Marı́a Cecilia; Schöpfer, Francisco J.; Lisdero, Constanza; Riobó, Natalia A.; Giulivi, Cecilia R; Boveris, Alberto; Boveris, A; Cadenas, Enrique

doi:10.1016/s0891-5849(98)00277-9

Cited by 148 publications

(88 citation statements)

References 41 publications

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“…On the contrary, it should be noted that through inhibition of O 2 consumption, NO • can modify electron flux through discrete sections of the respiratory chain. This leads to enhanced mitochondrial O 2 − generation, mainly due to auto-oxidation of ubiquinol [157][158][159]. Thus, it can be argued that the mitochondria can transduce a nitrosative signal into an oxidative signal, consistent with the proposed role of mitochondrial ROS in cytosolic signaling pathways [143].…”

Section: Apoptosis Mitochondrial Function and Mapk Signal Transductionmentioning

confidence: 61%

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

Schroeter

Boyd

Spencer

et al. 2002

Neurobiology of Aging

302

178

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Oxidative and nitrosative stress is increasingly associated with the pathology of neurodegeneration and aging. The molecular mechanisms underlying oxidative/nitrosative stress-induced neuronal damage are emerging and appear to involve a mode of death in which mitogen-activated protein kinase (MAPK) signaling pathways are strongly implicated. Thus, attention is turning towards the modulation of intracellular signaling as a therapeutic approach against neurodegeneration. Both endogenous and dietary agents have been suggested as potent modulators of intracellular signal transduction, e.g. nitric oxide and flavonoids, respectively. This review addresses recent findings on the biological effects of flavonoids and nitric oxide in neurodegeneration and aims to elucidate the rationale for their prospective use as modulators of cellular signal transduction. © 2002 Elsevier Science Inc. All rights reserved.Keywords: Apoptosis; Oxidative stress; Neuron; Flavonoids; MAP kinase; JNK; ERK; Epicatechin; Nitric oxide; Mitochondria; Redox status; Polyphenols Abbreviations: AKT, serine/threonine kinase (also known as protein kinase B); AP-1, activator protein-1; Apaf-1, apoptosis protease activating factor-1; ASK1, apoptosis signal-regulating kinase-1; Bad, Bcl-2/BclX Lassociated death promoting protein; Bax, pro-apoptotic protein of the Bcl-2 family; Bcl-2, B-cell lymphoma 2: protein with anti-apoptotic properties; BclX L , long form of Bclx: anti-apoptotic protein of the Bcl-2 family; Caspase, cysteinyl aspartic acid-protease; c-Jun, mammalian equivalent of Jun: part of the AP-1 transcription complex; CREB, cAMP response element binding protein; DIABLO/smac, mitochondria-related pro-apoptotic protein: inhibits XIAP; ERK1/2, extracellular signal-related kinase; Fas, CD95: member of the TNF receptor family; GSHST, glutathione Stransferase; JNK, c-Jun amino-terminal kinase; MAPK, mitogen-activated protein kinase; MAPKK, MAPK kinase; MAPKKK, MAPKK kinase; MEK1/2, ERK1/2-specific MAPKK; MKK4/7, JNK-specific MAPKK; MSK1, mitogen-and stress-activated kinase-1; NF-B, nuclear factor of immunoglobulin k locus in B-cells; ONOO − , peroxynitrite anion; p53, pro-apoptotic tumor suppressor gene product; PI3-kinase, phosphoinositol 3-kinase; Ras, small G-protein; RNS, reactive nitrogen species; ROS, reactive oxygen species; RSK, pp90 ribosomal S6 kinase; SAPK, stressactivated protein kinase; XIAP, X-linked inhibitor of apoptosis: inhibits the activation of caspase-9

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Section: Apoptosis Mitochondrial Function and Mapk Signal Transductionmentioning

confidence: 61%

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

Schroeter

Boyd

Spencer

et al. 2002

Neurobiology of Aging

302

178

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“…This process will depend not only on cell type, but also environmental factors such as ischemia. to proceed via reduction of NO • by SOD, [42] ferrocytochrome c, [43] and ubiquinol, [44] and/or reduction of GSNO by GSH and the alcohol dehydrogenase system. [45][46][47] Several groups have reported that HNO, per se a strong reductant, [48] can trigger reactions of oxidation.…”

Section: Chemical Fate Of No• In Biological Systemsmentioning

confidence: 99%

Inflammatory Modulation of Hepatocyte Apoptosis by Nitric Oxide: In Vivo, In Vitro, and In Silico Studies

Vodovotz¹,

Kim²,

Bagci³

et al. 2004

CMM

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“…5): both ! NO and ONOO ¡ may contribute to the buildup of ubisemiquinone according to reactions 5 and 6, respectively (53,54) and, accordingly, to the production of O ! ¡ 2 via reaction 1, which may represent the major mechanism for mitochondrial H 2 O 2 production.…”

Section: Mitochondria and Cell-death Pathwaysmentioning

confidence: 99%

Mitochondrial Production of Hydrogen Peroxide Regulation by Nitric Oxide and the Role of Ubisemiquinone

Boveris

Cadenas

2000

IUBMB Life

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The reaction of nitric oxide with ubiquinol: kinetic properties and biological significance

Cited by 148 publications

References 41 publications

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

Inflammatory Modulation of Hepatocyte Apoptosis by Nitric Oxide: In Vivo, In Vitro, and In Silico Studies

Mitochondrial Production of Hydrogen Peroxide Regulation by Nitric Oxide and the Role of Ubisemiquinone

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