The reaction of malononitrile with chalcone: a controversial chemical process

2-Amino-4-[1-(2-chlorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-6-(4-methylphenyl)benzene-1,3-dicarbonitrile

“…synthesized by a modification of a published procedure (Victory, et al 1991). To add 1.6 mL piperidine the mixture liquor…”

Synthesis of 3-amino-5-methyl-[1,1'-biaryl]-2,4-dicarbonitriles using ZnFe2O4 magnetic nanoparticles

“…Over the last decade, there have been reported many methods for the synthesis of dicyanoanilines [1,[7][8][9][10]. They are typically prepared from (i) a reaction between malononitrile and α,β-unsaturated ketones [11], (ii) reaction of ynones and malononitrile [12], (iii) one-pot tandem reaction of (alkylidene)malononitriles with nitroolefins in the presence of a base [13], (iv) ringtransformation of functionalized 2H-pyran-2-ones with malononitrile [14], (v) the threecomponent reaction of aldehydes, ketones and malononitrile under solvent-free conditions [7] (vi) and reaction between arylidenemalononitriles, dialkyl acetylenedicarboxylates and malononitrile catalyzed by 1-methylimidazole [15], or (vii) reactions between nitrostyrenes and excess malononitrile [10].…”

A Green and Efficient Synthesis of Bioactive 1, 2, 3 ‐ Triazolyl‐Pyridine/Cyanopyridine Hybrids via One‐Pot Multicomponent Grinding Protocol

“…In view of these bioactivities of the individual heterocycles, it was envisaged that the synthesis of hitherto novel hybrid molecules can be designed in which a single framework shall contain cyanopyridine and triazole. Literature provides enormous synthetic protocols for cyanopyridine derivatives, most of which involve either many steps, organic solvents or catalyst ,…”

“…In view of these bioactivities of the individual heterocycles, it was envisaged that the synthesis of hitherto novel hybrid molecules can be designed in which a single framework shall contain cyanopyridine and triazole. Literature provides enormous synthetic protocols for cyanopyridine derivatives, most of which involve either many steps, organic solvents [15][16][17][18][19][20][21][22][23][24][25][26] or catalyst. [27,28] With this in mind, we have recently reported the synthesis of various bioactive hybrids linking 1,2,3-triazole with many other heterocycles such as indoles, [29] pyrazolines, [30] N-acyl pyrazolines, [31] pyrimidine-2-thiones, [32] 2-aminopyrimidines [33] and pyridine [34] from easily accessible 1,2,3-triazole-chalcones via environ-friendly, greener pathways.…”