The reaction of benzylpenicillin with carbohydrates at neutral pH with a note on the immunogenicity of hapten polysaccharide conjugates

Schneider, Conrad H.; Weck, A.L. de

doi:10.1016/0019-2791(67)90116-4

Cited by 43 publications

(14 citation statements)

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“…From a microbiological point of view, a 22% fall in activity is acceptable, since the serum concentration would still be much higher than the minimal inhibitory concentration for most bacterial strains. From an immunological point of view, however, a 22% activity fall might lead to the formation of immunogenic and allergenic breakdown products, which may be important in the allergic reactions caused by penicillins (4,10).…”

Section: Discussionmentioning

confidence: 99%

Stability of Antibiotics and Amino Acids in Two Synthetic l -Amino Acid Solutions Commonly Used for Total Parenteral Nutrition in Children

Colding

Andersen

1978

Antimicrob Agents Chemother

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The stability and interaction at 290C of ampicillin, carbenicillin, gentamicin, and polymyxin B were examined in a common electrolyte solution, invertose darrow, and in two synthetic L-anmno acid solutions, one commercial (vamin with fructose; Vitrum) and the other a neonatal preparation modified for use in newborn infants. The concentration of amino acids was measured before and after the addition of these antibiotics. The concentration of antibiotics was measured over a 24-h period with a microbiological method. The concentration of ampicillin in invertose darrow fell 52%, and in vamin with fructose it fell 69%, whereas in the neonatal preparation the fail was only 22%. The concentration of carbenicillin in vamin with fructose fell 37%, and in the neonatal preparation it fell 31%. The combination of ampicillin or carbenicillin with gentamicin or polymyxin B did not influence the activity of the penicillins. The concentration of gentamicin and polymyxin B was unchanged in all solutions over a 24-h period. With the exception of cystine, the concentration of all amino acids remained constant after 24 h in the neonatal preparation with and without the different combinations of antibiotics. For cystine there was a fall of 20 to 30%.Since the appearance of intravenous solutions containing synthetic amino acids and lipid, it has become possible to cover patients' needs for protein, energy, electrolytes, vitamins, and essential fatty acids by so-called total parenteral nutrition (TPN). Within the last few years, this treatment has been used successfully even in small newborn infants. To avoid contamination of the solutions during infusion, it is necessary to use a closed infusion system. Addition of antibiotics to the solutions before the start of the infusion would therefore be preferable to intravenous injection via the system or intramuscular injections, which may often cause problems, particularly in very small newborns with reduced muscle mass. Furthermore, by adding antibiotics to the fluids, which are infused via a pump, it is possible to maintain a steady-state concentration higher than the minimal inhibitory concentration for most bacterial strains. Aminoglycosides administered in such a way have been shown to result in a high cure rate in adults (1).

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Section: Discussionmentioning

confidence: 99%

Stability of Antibiotics and Amino Acids in Two Synthetic l -Amino Acid Solutions Commonly Used for Total Parenteral Nutrition in Children

Colding

Andersen

1978

Antimicrob Agents Chemother

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“…Insbesondere in der Diagnostik medikamentös-allergischer Erkrankungen hat sich der Test seit ca. 40 Jahren bewährt [3,4,5].Auch in der Umweltmedizin erhoffte man sich von diesem Test Hinweise auf die Ätiopathogenese unklarer Erkrankungen, bei denen der Verdacht auf allergische Reaktionen gegenüber "Umweltstoffen" (Metalle, Nahrungsmittel, Toxine etc.) bestand.…”

Section: Introductionunclassified

Diagnostische Relevanz des Lymphozytentransformationstestes in der Umweltmedizin

2002

Bundesgesundheitsbl - Gesundheitsforsch - Gesundheitsschutz

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“…These preparations were stable when kept in frozen solution but lost their penicilloyl groups at pH 7.4 within several days at 37° by liberating pcnicilloic acid. Table III summarizes results obtained by immunizing two groups of random bred guinea pigs (R and E) with four BPO-conjugates of different molecular weight [16,17]. The mean molecular weights were 5,000 for the BPO-inulin, 10,000 and 20,000 respectively for the BPO-dextrans and 400,000 for the BPOFicoll.…”

Section: Penicilloyl Polysaccharidesmentioning

confidence: 99%

Immunochemical Aspects of Penicillin Chemistry

Schneider¹,

Weck²

1969

Int Arch Allergy Immunol

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The reaction of benzylpenicillin with carbohydrates at neutral pH with a note on the immunogenicity of hapten polysaccharide conjugates

Cited by 43 publications

References 10 publications

Stability of Antibiotics and Amino Acids in Two Synthetic l -Amino Acid Solutions Commonly Used for Total Parenteral Nutrition in Children

Stability of Antibiotics and Amino Acids in Two Synthetic l -Amino Acid Solutions Commonly Used for Total Parenteral Nutrition in Children

Diagnostische Relevanz des Lymphozytentransformationstestes in der Umweltmedizin

Immunochemical Aspects of Penicillin Chemistry

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