The RBE of Tritium Radiation Measured in Mouse Oocytes: Increase at Low Exposure Levels

Rats were continuously exposed to constant activity of tritium in drinking water (HTO group) or to tritium organically bound in food (T-food group) in the period from conception of F1 generation through maturity. Female offspring were killed at the age of 21 and 71 days and the oocytes in their ovaries were counted. Mean dose rates absorbed in the ovaries were for the HTO groups 7.25 +/- 0.37 and 14.73 +/- 0.79 mGy/day and for the T-food group 4.84 +/- 0.25 mGy/day. Reduction in the oocyte number in the ovaries of females exposed to tritiated food was bigger than in the ovaries of females exposed to tritiated water. The dependence of the survival of small oocytes on the dose rate and the corresponding total accumulated dose had an exponential character. The damaging effect of tritium was for the period from conception to 21 days of age bigger than from 21 to 71 days of age. Of all stages of oocyte development, the highest sensitivity to tritium irradiation was observed in small oocytes and oocytes with one complete layer of follicle cells. As a result, relative number of growing and large oocytes increased.

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“…An exponential character of the dose-response was also observed by Dobson and Kwan [6] in the studies on mice.…”

Section: Resultssupporting

confidence: 49%

“…It has been reported that internal exposure of females to tritium resulted in the reduction of oocyte number in their ovaries [5,6,8,9,12,14,18,24]. The effect depends on the species, age, activity of administered tritium and its chemical form.…”

Section: Introductionmentioning

confidence: 99%

Effect of lifetime intake of organically bound tritium and tritiated water on the oocytes of rats

Pietrzak-Flis

Wasilewska-Gomułka

1984

Radiat Environ Biophys

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“…Kellerer and Rossi 1972, 1973a, Hall, Novak, Kellerer, Rossi, Marino and Goodman 1975, Amols, Di ello and Lane 1975, de Choudens, Gilet, Roux and Fabre 1975, Dobson and Kwan 1976 . The present results show, however, that k must vary by a large fa tor .…”

Section: Dis Ussion 1 ' Site Model' Interpretationmentioning

confidence: 98%

Inactivation and Mutation of Cultured Mammalian Cells by Aluminium Characteristic Ultrasoft X-rays

1977

International Journal of Radiation Biology and Related Studies

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Microdosimetric distributions for aluminium K characteristic ultrasoft X-rays and 4He ion tract intersections are calculated and used to analyse recent biological results obtained with these radiations. Results on inactivation and mutation-induction to thioguanine resistance of both V79 Chinese hamster cells and HF19 human diploid fibroblasts in vitro are analysed in terms of the Kellerer-Rossi "theory of dual radiation action". The small quantum energy of the aluminium X-ray photons and the very short length of the secondary electrons which they produce highlight the inadequacy of the model. It is shown that the model predicts r.b.e. values in conflict with those observed unless an additional variable is introduced, but that the introduction of such a variable creates mathematical inconsistencies. The experimental evidence is contrary to the conventional usage and basis of the model.

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“…Second, revised ternary fission yield data for fast reactor fuels suggest that previous estimates of tr.tiur.i production via that process may have been low by as much as one order of magnitude (1,2). Third, recent experimental results suggest, that it may be desirable to increase the quality factor (Q) for tritium beta'particles from the present recommended value of I to a higher value (e.g., 2), particularly for low-dose rates and low-dose exposures (3,4,5). The estimated dose for tritium exposure would increase in direct proportion to any increase in the Q.…”

Section: Introductionmentioning

confidence: 99%

Estimation of dose to man from environmental tritium

Rohwer¹,

Etnier²

1980

The International Journal of Applied Radiation and Isotopes

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The RBE of Tritium Radiation Measured in Mouse Oocytes: Increase at Low Exposure Levels

Cited by 46 publications

References 14 publications

Effect of lifetime intake of organically bound tritium and tritiated water on the oocytes of rats

Effect of lifetime intake of organically bound tritium and tritiated water on the oocytes of rats

Inactivation and Mutation of Cultured Mammalian Cells by Aluminium Characteristic Ultrasoft X-rays

Estimation of dose to man from environmental tritium

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