The rationality for using prodrug approach in drug discovery programs for new xenobiotics: opportunities and challenges

Srinivas, Nuggehally R.

doi:10.1007/s13318-011-0035-z

Cited by 11 publications

(5 citation statements)

References 55 publications

(91 reference statements)

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“…Other xenobiotics need assistance to obtain similar effects. 104 For the sake of this review, both assistance with xenobiotic delivery and activity will be summarized with one indicator on the chart, although the two categories “aid” quite differently. “Delivery aids” encompass structural modifications ( i.e.…”

Section: Recent Studies On Botanical Nps and Associated Drug Developm...mentioning

confidence: 99%

Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer

et al. 2023

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Section: Recent Studies On Botanical Nps and Associated Drug Developm...mentioning

confidence: 99%

Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer

et al. 2023

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“…For example, a broad-spectrum herbicide, such as isoxaflutole, does not have a promoiety or carrier, but after biotransformation, diketonitrile is the metabolite of isoxaflutole which is the actual inhibitor and herbicide (Figure 7). For the carrier-linked prodrug, once it enters the organism, it undergoes enzymatic or non-enzymatic cleavage to release the originally active agent and carrier [82,88,89]. Types of carrier-linked prodrugs include esters, amides, phosphates, carbamates, carbonates, oximes, imines, and N-Mannich bases.…”

Section: Targeted Herbicide Discovery and Developmentmentioning

confidence: 99%

The Progress towards Novel Herbicide Modes of Action and Targeted Herbicide Development

Wang

et al. 2022

Agronomy

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To date, effectively controlling resistant weeds has been a great challenge in modern agricultural production. Developing new modes of action of herbicides would be an efficient, convenient, and timely means of controlling resistant weeds. In particular, new modes of herbicide action do not appear to have evolutionary resistance or cross-resistance with existing herbicides. However, a few successful herbicides with new modes of action (MoAs) have been marketed in the past 20 years. In this paper, we analyzed limiting factors for the slow development of novel herbicide MoAs. We then summarized the positive herbicide targets for the herbicides that have been discovered in recent years, such as Solanyl Diphosphate Synthase (SPS), Fatty Acid Thioesterase (FAT), Plastid Peptide Deformylase (PDEF), and Dihydroxy-Acid Dehydratase (DHAD). Some commercial herbicide varieties have been obtained based on novel herbicide targets, such as Homogentisate Solanesyltransferase (HST) and Dihydroorotate Dehydrogenase (DHODH). This provides a new reference and idea for herbicide molecular design in the future. In addition, some practical and efficient methods were mentioned for the rational design, discovery, and development of targeted herbicides development. In order to overcome the adverse conditions of compound druggability, prodrug strategies are also used in herbicide development, which can optimize the administration, permeability, absorption, and distribution of the original drug molecule or a candidate compound and may provide more possibilities for the development of new herbicides. The development of new herbicides is fascinating, the challenges and rewards are great, and the path to success is becoming more apparent.

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“…12). No carrier is present in this type of example, but the molecule must be metabolized to undergo functional group transformation [37][38][39] . Some examples include nabumetone (relafen), prontosil (Fig.…”

Section: Sultamicillinmentioning

confidence: 99%

Highly Efficient Prodrugs: Design and Therapeutic Applications

Pal¹,

Banik

2020

Orient. J. Chem

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Prodrug is a very powerful way for the improvement of biopharmaceutical, physicochemical, or pharmacokinetic possessions of pharmacologically dynamic mediators. Prodrug is a pharmacologically not an active compound, which can be converted into an active drug by biotransformation which is metabolic and such process the efficiency of drugs gets improved with specific target delivery. The conversion of a prodrug to drug may happen before concentration, after concentration, or at a precise part of the physique. This approach has many advantages over drug administration which is in our convention. In this review, different types of carriers, which can be used for prodrug synthesis are summarized. Examples of both marketed and investigational prodrugs from several promoieties are discussed not only for their advantages and uses but also their prospects. The purpose of this review is to introduce in detail the foundation behind the use of the prodrug methodology from past to present, and at the same time, to consider the possible consequences, which may evolve from insufficient initiation of prodrugs. Furthermore, the concept of prodrug and the classifications of prodrugs will be discussed in this article and it is expected that this review will be helpful for medicinal chemists for their research in the upcoming days.

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The rationality for using prodrug approach in drug discovery programs for new xenobiotics: opportunities and challenges

Cited by 11 publications

References 55 publications

Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer

Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer

The Progress towards Novel Herbicide Modes of Action and Targeted Herbicide Development

Highly Efficient Prodrugs: Design and Therapeutic Applications

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