The rationale and design of the LATTEE registry – the first multicenter project on the Scientific Platform of the “Club 30” of the Polish Cardiac Society

Kapłon‐Cieślicka, Agnieszka; Budnik, Monika; Gawałko, Monika; Wójcik, Maciej; Błaszczyk, Robert; Uziębło‐Życzkowska, Beata; Krzesiński, Paweł; Starzyk, Katarzyna; Gorczyca, Iwona; Szymańska, Anna; Dłużniewski, Mirosław; Daniłowicz‐Szymanowicz, Ludmiła; Kaufmann, Damian; Mizia‐Szubryt, Magdalena; Wybraniec, Maciej T.; Haberka, Maciej; Kucio, Michał; Tomaszuk‐Kazberuk, Anna; Wilk, Katarzyna; Burchardt, Paweł; Gościńska-Bis, Kinga; Hiczkiewicz, Jarosław; Łojewska, Katarzyna; Koziński, Marek; Michalski, Błażej; Tomaszewski, A.; Ścisło, Piotr; Kochanowski, Janusz; Filipiak‬, Krzysztof J.; Opolski, Grzegorz

doi:10.33963/kp.15011

Cited by 8 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients treated with apixaban more often received reduced doses (29%) compared to patients on rivaroxaban (14%) and dabigatran (17%; p < 0.01 for both comparisons; Figure 1 B). Patients on apixaban were older, more often had non-paroxysmal AF, had more comorbidities with higher median CHA 2 DS 2 -VASc score (4 [ 2 , 3 , 4 , 5 ] for apixaban vs. 3 [ 2 , 3 , 4 ] for rivaroxaban and 3 [ 1 , 2 , 3 , 4 ] for dabigatran; p < 0.01), had lower GFR, and more often a history of bleeding and anemia, and were more often treated with antiplatelets compared to patients on other NOACs ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The Left Atrial Thrombus on Transesophageal Echocardiography (LATTEE) registry (NCT03591627) was a prospective, observational study enrolling consecutive patients with AF or AFl in whom TEE was performed before direct current cardioversion or catheter ablation, hospitalized in 13 cardiology departments (11 academic centers and two territorial departments) in Poland. Details on the study rationale and design have been reported elsewhere [ 5 ]. The patient recruitment process started in November 2018 in the coordinating centre and lasted 12 months since the beginning of the study in each participating centre or longer, i.e., until the inclusion of at least 200 patients at each participating centre (with the last patient enrolled in May 2020).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Left Atrial Thrombus in Atrial Fibrillation/Flutter Patients in Relation to Anticoagulation Strategy: LATTEE Registry

Kapłon‐Cieślicka

Gawałko

Budnik

et al. 2022

JCM

Self Cite

View full text Add to dashboard Cite

Background: Atrial fibrillation (AF) and flutter (AFl) increase the risk of thromboembolism. The aim of the study was to assess the prevalence of left atrial thrombus (LAT) in AF/AFl in relation to oral anticoagulation (OAC). Methods: LATTEE (NCT03591627) was a multicenter, prospective, observational study enrolling consecutive patients with AF/AFl referred for transesophageal echocardiography before cardioversion or ablation. Results: Of 3109 patients enrolled, 88% were on chronic, 1.5% on transient OAC and 10% without OAC. Of patients on chronic OAC, 39% received rivaroxaban, 30% dabigatran, 14% apixaban and 18% vitamin K antagonists (VKA). Patients on apixaban were oldest, had the worst renal function and were highest in both bleeding and thromboembolic risk, and more often received reduced doses. Prevalence of LAT was 8.0% (7.3% on chronic OAC vs. 15% without OAC; p < 0.01). In patients on VKA, prevalence of LAT was doubled compared to patients on non-VKA-OACs (NOACs) (13% vs. 6.0%; p < 0.01), even after propensity score weighting (13% vs. 7.5%; p < 0.01). Prevalence of LAT in patients on apixaban was higher (9.8%) than in those on rivaroxaban (5.7%) and dabigatran (4.7%; p < 0.01 for both comparisons), however, not after propensity score weighting. Conclusions: The prevalence of LAT in AF is non-negligible even on chronic OAC. The risk of LAT seems higher on VKA compared to NOAC, and similar between different NOACs.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Left Atrial Thrombus in Atrial Fibrillation/Flutter Patients in Relation to Anticoagulation Strategy: LATTEE Registry

Kapłon‐Cieślicka

Gawałko

Budnik

et al. 2022

JCM

Self Cite

View full text Add to dashboard Cite

show abstract

“…In total, 3,109 AF or AFl patients were included in the study. Detailed data about the entire LATTEE registry group were included in previous manuscripts ( 9 , 10 ).…”

Section: Resultsmentioning

confidence: 99%

“…The reasons for admission were catheter ablation or cardioversion and TEE performed directly before the procedure. The methods of the study were previously described in detail ( 9 , 10 ). Briefly, consecutive hospitalized patients diagnosed with AF/AFl who underwent TEE before direct current cardioversion or catheter ablation were included in the registry.…”

Section: Methodsmentioning

confidence: 99%

Risk factors for left atrial thrombus in younger patients (aged < 65 years) with atrial fibrillation or atrial flutter: Data from the multicenter left atrial thrombus on transesophageal echocardiography (LATTEE) registry

Uziębło‐Życzkowska

Kapłon‐Cieślicka

Gawałko

et al. 2022

Front. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

BackgroundOur aim was to assess the characteristics and to identify predictors of left atrial thrombus (LAT) in patients under age 65 with atrial fibrillation (AF) or atrial flutter (AFl).MethodsWe conducted a subanalysis of a multicenter, prospective, observational study [the LATTEE registry]. Consecutive AF/AFl patients referred for cardioversion or ablation were enrolled.ResultsOf the 3,109 patients included in the study, 1,276 were under age 65 (41%). Compared to non-LAT patients, those with LAT (n = 76) had higher CHA2DS2-VASc score (p < 0.001), more frequently had non-paroxysmal AF/AFl (p < 0.001), heart failure (p < 0.001), history of diabetes mellitus (p = 0.001), transient ischemic attack (p = 0.04), coronary artery disease (p = 0.02), and chronic kidney disease (p < 0.001). The LAT patients were also more often smokers (p = 0.004) and were more frequently treated with vitamin K antagonists (VKAs) (p < 0.001). Transthoracic echocardiography revealed a higher left atrial area (p < 0.001), lower left ventricular ejection fraction (LVEF) (p < 0.001), and lower value of LA appendage emptying volume in LAT than in non-LAT patients (p < 0.001). LVEF (OR 2.95; 95% CI: 1.32–6.59, p = 0.008), non-paroxysmal AF/AFl (OR 7.1; 95% CI: 2.05–24.63, p = 0.002) and treatment with VKAs (OR 4.92; 95% CI: 2.48–9.75, p < 0.001) were identified as independent predictors of LAT in younger patients.ConclusionsOur study, which focused on younger patients with AF/AFl, indicated substantial clinical and echocardiographic differences between participants with and without LAT. In the AF/AFl patients younger than age 65, the independent predictors of LAT included non-paroxysmal AF/AFl, lower LVEF, and treatment with VKAs.

show abstract

“…It is worth mentioning that both departments are participating in a new Polish multicenter prospective registry called Left Atrial Thrombus on TEE (LATEE). This study hopes to analyze the larger groups of patients contained in this registry, especially for the optimal management of LAA thrombus or sludge [29].…”

Section: Discussionmentioning

confidence: 99%

Risk of Death and Ischemic Stroke in Patients with Atrial Arrhythmia and Thrombus or Sludge in Left Atrial Appendage at One-Year Follow-Up

Kosmalska¹,

Gilis‐Malinowska

Rzyman³

et al. 2022

JCM

View full text Add to dashboard Cite

Thrombus in the left atrial appendage is a contraindication for cardioversion. Sludge is considered similarly as threatening as thrombus; however, the risk of death and ischemic stroke in patients with atrial arrhythmia and thrombus or sludge is not well-known. This study focused on assessing the risk of death and ischemic stroke at one-year follow-up in patients with atrial arrhythmia and thrombus or sludge, as well as the effectiveness of anticoagulation in thrombus resolution. 77 out of 267 (29%) of patients who were scheduled for cardioversion were diagnosed with thrombus or sludge. The annual mortality in patients with thrombus or sludge was 23%. In the group without thrombus, the annual mortality was 1.6%. Overall, 17% of patients with thrombus or sludge experienced ischemic stroke. In patients without thrombus, the risk of stroke was 1%. Sludge increased risk of stroke compared to those without thrombus or sludge by 11% vs. 1%, respectively. No differences in mortality or stroke prevalence were observed between sludge and thrombus. Thrombus or sludge in the LAA have a poor prognosis. A diagnosis of sludge has a similar impact on risk of ischemic strokes as does a diagnosis of thrombus.

show abstract

The rationale and design of the LATTEE registry – the first multicenter project on the Scientific Platform of the “Club 30” of the Polish Cardiac Society

Cited by 8 publications

References 0 publications

Left Atrial Thrombus in Atrial Fibrillation/Flutter Patients in Relation to Anticoagulation Strategy: LATTEE Registry

Left Atrial Thrombus in Atrial Fibrillation/Flutter Patients in Relation to Anticoagulation Strategy: LATTEE Registry

Risk factors for left atrial thrombus in younger patients (aged < 65 years) with atrial fibrillation or atrial flutter: Data from the multicenter left atrial thrombus on transesophageal echocardiography (LATTEE) registry

Risk of Death and Ischemic Stroke in Patients with Atrial Arrhythmia and Thrombus or Sludge in Left Atrial Appendage at One-Year Follow-Up

Contact Info

Product

Resources

About