Drug Design 1971
DOI: 10.1016/b978-0-12-060302-2.50014-2
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The Rational Design of Antiviral Agents

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Cited by 1 publication
(2 citation statements)
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“…Seminal studies on the remarkable antiviral properties of triphenylmethane dyes discovered over four decades ago [21][22][23]25,26] have prompted investigations of their potential use as lead compounds in targeting SARS-CoV-2. In the search for novel activities via HTS assays utilizing the LOPAC arsenal of compounds, ATA is often identified among positive hits in drug discovery campaigns, including those in the quest for SARS-CoV-2 therapies [34].…”
Section: Discussionmentioning
confidence: 99%
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“…Seminal studies on the remarkable antiviral properties of triphenylmethane dyes discovered over four decades ago [21][22][23]25,26] have prompted investigations of their potential use as lead compounds in targeting SARS-CoV-2. In the search for novel activities via HTS assays utilizing the LOPAC arsenal of compounds, ATA is often identified among positive hits in drug discovery campaigns, including those in the quest for SARS-CoV-2 therapies [34].…”
Section: Discussionmentioning
confidence: 99%
“…The synthesis of ATA traces its origin to 1892 as the primary product of a condensation reaction between salicylic acid and formaldehyde in the presence of sulfuric acid and nitrite ion [16]. Multiple applications have been reported since its discovery, including seminal studies conducted during the 1960s and 1970s [17] that explored ATA as an inhibitor of protein synthesis in eukaryotes while elucidating specific mechanisms of several antiviral and antibiotic compounds at the ribosomal level [18][19][20][21][22][23][24][25][26]. Harnessing insights gained from parallel investigations on emetine [17][18][19]24,27], Grollman and colleagues focused particular attention on the initiation of viral protein synthesis as a target for anti-viral drug design.…”
Section: Introductionmentioning
confidence: 99%