The Ratio of Metastatic/Resected Lymph Nodes is an Independent Prognostic Factor in Patients With Node-positive Pancreatic Head Cancer

Sierżęga, Marek; Popiela, T; Kulig, Jan; Nowak, Karol

doi:10.1097/01.mpa.0000235306.96486.2a

Cited by 118 publications

(104 citation statements)

References 34 publications

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“…The vascular invasion in tumours was not studied in the cited cohorts presenting OS except in the Robinson's study; however, the authors were unable to prove that this factor had a statistically significant effect on the 5-year survival 24 . Other studies proved, in accordance with our study, that PNI and VI were associated with poor survival following pancreaticoduodenectomy [25][26][27] . Surprisingly, one study presented VI along with PNI to be an independent favourable prognostic factor in patients with locally advanced and metastatic pancreatic cancer 28 .…”

Section: Discussionsupporting

confidence: 77%

Long-term survival after resections for pancreatic ductal adenocarcinoma. Single centre study

Loveček¹,

Skalický²,

Klos³

et al. 2016

BIOMED PAP

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Aim. To analyse the 5-year survival rate of patients undergoing radical surgery for pancreatic ductal adenocarcinoma (PDAC) and to identify prognostic factors. Methods. A prospectively maintained database of 90 consecutive patients who underwent radical resection for PDAC was analysed. Survival was evaluated using the Kaplan-Meier method. Log-rank test and Cox regression analysis were used for the evaluation of prognostic factors. P values less than 0.05 were considered significant. Results. Mean age (± standard deviation) was 63.2±8.6 years (female 28.9% and male 71.1%). Tumour localisation was in the head in 76 (84.5%), multifocal in 3 (3.3%) and in the body/tail in 11 (12.2%). Pancreatic head resection was performed in 75 (83.3%), total pancreatectomy in 4 (4.4%) and distal pancreatectomy with splenectomy in 11 (12.2%), with standard lymphadenectomy. Venous resection was in 4 (4.4%). Thirty-day and in-hospital mortality occurred in 1 (1.1%), 90-day mortality was 3.3%. On univariate analysis absence of perineural and vascular invasion, stage, absence of lymph node infiltration and no need for transfusion were associated with improved overall survival. On multivariate analysis vascular invasion HR=3.137 (95%CI: 1.692-5.816; P = 0.0003) and postoperative complications HR=2. ; P = 0.008) were identified as significant independent predictors of survival. The five-year survival rate was 18.9%, with five-year recurrence-free survival of 16.7%. Conclusion. Vascular invasion and postoperative complications were independent prognostic factors after curative resections of pancreatic cancer in studied cohort.

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Section: Discussionsupporting

confidence: 77%

Long-term survival after resections for pancreatic ductal adenocarcinoma. Single centre study

Loveček¹,

Skalický²,

Klos³

et al. 2016

BIOMED PAP

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“…We have observed similar changes in the early postoperative outcomes and long-term survival as those reported by other authors (Popiela et al, 2002b;Sierzega et al, 2006). In particular, a significant lowering trend of postoperative mortality rates was found from values exceeding 10% in the early eighties to an average of 4.1% in the last decade ( fig.…”

Section: Wwwintechopencomsupporting

confidence: 89%

Temporal Trends in Pancreatic Cancer

Popiela¹,

Sierżęga²

2012

Pancreatic Cancer - Clinical Management

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“…The prognostic significance of the absolute number and/or ratio of positive nodes has been reported in other solid tumours (van der Velden et al, 1995;Moore and Stehman, 1996;Tepper et al, 2001;Bando et al, 2002;Herr et al, 2002;Weir et al, 2002;Gajra et al, 2003;Joseph et al, 2003;Le Voyer et al, 2003;Berger et al, 2005;Sierzega et al, 2006). In breast cancer, the nodal ratio has been shown to be an important predictor of loco-regional recurrence and survival both from initial diagnosis and following recurrence (Nieto et al, 2002;Grills et al, 2003;Woodward et al, 2006).…”

Section: Discussionmentioning

confidence: 84%

The impact of the absolute number and ratio of positive lymph nodes on survival of endometrioid uterine cancer patients

et al. 2007

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The aim of the study was to determine the impact of the absolute number and ratio of positive lymph nodes on the survival in nodepositive endometrioid uterine cancer. Data were obtained from the National Cancer Institute Registry from 1988 to 2001. Analyses were performed using Kaplan -Meier and Cox proportional hazard methods. A total of 1222 women were diagnosed with stage IIIC-IV node-positive endometrioid corpus cancer. The 5-year disease-specific survival of women with 1, 2 -5, and 45 positive nodes were 68.1, 55.1, and 46.1%, respectively (Po0.001). Increasing lymph node ratio, expressed as a percentage of positive nodes to total nodes identified (p10, 410 -p50, and 450%), was associated with a decrease in survival from 77.3 to 60.7 to 40.9%, respectively (Po0.001). The absolute number of positive nodes and the lymph node ratio remained significant after adjusting for stage (IIIC vs IV) and the extent of lymphadenectomy (p20 vs 420 nodes). On multivariate analysis, the absolute number of positive nodes and lymph node ratio were significant independent prognostic factors for survival. Increasing absolute number of positive nodes and lymph node ratio are associated with a poorer survival in women with node-positive uterine cancers. The stratification of nodepositive uterine cancer for prognostic and treatment purposes warrants further investigation.

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The Ratio of Metastatic/Resected Lymph Nodes is an Independent Prognostic Factor in Patients With Node-positive Pancreatic Head Cancer

Abstract: Lymph node ratio seems to be a new promising prognostic factor in patients with respectable node-positive pancreatic head cancer.

Cited by 118 publications

References 34 publications

Long-term survival after resections for pancreatic ductal adenocarcinoma. Single centre study

Long-term survival after resections for pancreatic ductal adenocarcinoma. Single centre study

Temporal Trends in Pancreatic Cancer

The impact of the absolute number and ratio of positive lymph nodes on survival of endometrioid uterine cancer patients

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