The Ratio of Blood Levels of Saturated Fatty Acids and Metabolites of Carbohydrate Metabolism in Residents of the Arctic Aged 22–35 Years

Bichkaev, Artem; Бичкаева, Ф. А.; Volkova, Natalya; Tretyakova, T. V.; Власова, О С; Nesterova, Ekaterina; Shengof, Boris; Baranova, N. F.

doi:10.17238/issn2542-1298.2017.5.2.44

Cited by 2 publications

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“…(12)(13)(14) Although early studies have shown associations between PUFA imbalances and a number of diseases, (3,15,16) there is insufficient information on the content of PUFAs in clinically healthy individuals living in the Arctic and Arctic regions. (17,18) Polar human physiology merits intensified study because such a study would increase our knowledge of basic principles of biomedicine.…”

Section: Introductionmentioning

confidence: 99%

Polyunsaturated Fatty Acids of Blood Serum and the Assessment of their Ratios in Clinically Healthy Adults Living in the Arctic Territories of Russia

Бичкаева¹,

Galstyan²,

Волкова³

et al. 2019

IJBM

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Background: The study of the content of polyunsaturated fatty acids (PUFAs) in permanent residents of the Arctic territories, characterized by high activity of lipid metabolism, is of undoubted interest. The aim of this study was to assess the composition of omega-3 and omega-6 PUFAs in blood serum by gas-liquid chromatography and individual PUFA ratios in clinically healthy adults living in the Russian Arctic and Sub-Arctic regions. Materials and Methods: A total of 1,556 healthy adult residents (the age groups of 22-35, 36-45 and 46-60 years) of the northern territories were examined. Of these, 661 people were living in the Sub-Arctic region (SAR) and 895 people in the Arctic region (AR). Analysis of PUFA composition in blood serum was determined by gas-liquid chromatography after transesterification to volatile fatty acid methyl esters (FAME). We determined the content of ω-3 PUIFAs: α-linolenic acid (ALA), eicosatrienoic acid (ETE), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA); and ω-6 PUFAs: dihomo-γlinolenic acid (DGLA), linoleic acid (LA), arachidonic acid (AA), docosatetraenoic acid with the common name adrenic acid (AdA). Results: In the clinically healthy individuals born and permanently living in SAR and AR, there was an age-related increase in LA level combined with an increase in the levels of AA, AdA and DGLA, as well as an increase in ALA level combined with an increase in the levels of EPA, DPA and DHA, the content of which was higher in AR individuals. In all age groups of adult residents of SAR, an increase in the AA/EPA ratio and a decrease in the EPA/DPA and (DGLA EPA)/DHA values were observed relative to similar age groups of AR, which indicates disorders in the PUFA metabolism and intensification of pro-inflammatory eicosanoid synthesis. In AR, a statistically significant increase in both ω-3 and ω-6 PUFAs can be a compensatory-adaptive reaction aimed at preserving the lipid component of cell membranes and reducing the risk of their destruction. An increase in the AA/DGLA ratio can be considered as a hidden risk criterion for the synthesis of pro-inflammatory eicosanoids.

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Section: Introductionmentioning

confidence: 99%

Polyunsaturated Fatty Acids of Blood Serum and the Assessment of their Ratios in Clinically Healthy Adults Living in the Arctic Territories of Russia

Бичкаева¹,

Galstyan²,

Волкова³

et al. 2019

IJBM

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Phenotypic Characteristics of the Chuya Kazakhs and Southern Altaians

Chanchaeva

Sukhova

Айзман

2020

Ekologiya cheloveka (Human Ecology)

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The aim is to identify gender phenotypic signs of adaptation of the Kazakh and Altai populations to the conditions of Southeast Altai. Tasks: to characterize the morphological indicators of adolescents (13-15 years old) and adults (20-29 years old), depending on nationality and gender; to evaluate the macronutrient analysis of the daily food allowance and the biochemical parameters of blood plasma of adult Kazakhs and Altaians of both sexes. Methods. The study was conducted in the Kosh-Agach district of the Altai Republic. Length and body weight were assessed in Kazakh and Altai teenagers, and beside that the macronutrient analysis of the daily food allowance, as well as the level of cholesterol, triglycerides, total protein, albumin, glucose, high and low density lipoproteins in the blood plasma were estimated in adults. Results. The adult Kazakh population of Gorny Altai was found to be similar to the native Altai population according to morphological characteristics, type of nutrition, and plasma lipid indices. Compared to Altaians, they have more pronounced manifestations of sexual dimorphism in terms of length and body weight. In the puberty, Kazakh boys are significantly shorter not only their herd mates of a homogeneous population, but also peers from Northern Kazakhstan. Conclusion. The climatic and geographical conditions of the Altai highlands determine the manifestation of the following phenotypic signs in the Kazakh population: hyperstenoid body type, high fat intake, metabolic processes that ensure the stability of blood plasma lipids, more pronounced signs of sexual dimorphism at different stages of ontogenesis.

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The Ratio of Blood Levels of Saturated Fatty Acids and Metabolites of Carbohydrate Metabolism in Residents of the Arctic Aged 22–35 Years

Cited by 2 publications

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Polyunsaturated Fatty Acids of Blood Serum and the Assessment of their Ratios in Clinically Healthy Adults Living in the Arctic Territories of Russia

Polyunsaturated Fatty Acids of Blood Serum and the Assessment of their Ratios in Clinically Healthy Adults Living in the Arctic Territories of Russia

Phenotypic Characteristics of the Chuya Kazakhs and Southern Altaians

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