This is a summary of the research of Charles L. Perrin and his coworkers in the areas of aromatic mercuration, vibronic borrowing, ipso factors in electrophilic aromatic substitution, malonic anhydrides, mechanisms of proton exchange in amides, stereoelectronic control, the socalled reverse anomeric effect, an NMR titration method for highly accurate measurement of relative acidities, secondary deuterium isotope effects on acidity, symmetry of hydrogen bonds in solution, and nucleophilic addition to a para-benzyne diradical, along with Perrin's contributions to teaching and to service.
Keywords:hydrogen bonds para-benzyne NMR titration isotope effects stereoelectronic control reverse anomeric effect vibronic borrowing electrophilic aromatic substitution malonic anhydrides proton exchange in amides Special thanks go to my dear wife Marilyn for her presence and support during these fifty years and for preparing a delicious dinner for the speakers and out-of-town guests the night before the symposium.After 50 years at UCSD I am still not retired but continue to enjoy teaching and research.