The rate of training response to aerobic exercise affects brain function of rats

Marton, Orsolya; Koltai, Erika; Takeda, Masaki; Mimura, Toshihide; Pajk, Melitta; Ábrahám, Dóra; Koch, Lauren G.; Britton, Steven L.; Higuchi, Mitsuru; Boldogh, István; Radák, Zsolt

doi:10.1016/j.neuint.2016.05.012

Cited by 9 publications

(7 citation statements)

References 43 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings suggest that aerobic training leads to exercise tolerance, evidenced by an increased maximal velocity, as demonstrated in experimental studies that use aerobic training [28,29]. The repetitive muscle contraction during exercise training can lead to a variety of responses that increase aerobic metabolism capacity and exercise tolerance [36][37][38].…”

Section: Discussionsupporting

confidence: 65%

See 1 more Smart Citation

Aerobic training reduces oxidative stress in skeletal muscle of rats exposed to air pollution and supplemented with chromium picolinate

et al. 2018

View full text Add to dashboard Cite

(2018) Aerobic training reduces oxidative stress in skeletal muscle of rats exposed to air pollution and supplemented with chromium picolinate, Redox Report, 23:1, 146-152, DOI: 10.1080/13510002.2018 Objective: The purpose of this study was to investigate the effects of chromium picolinate (CrPic) supplementation associated with aerobic exercise using measures of oxidative stress in rats exposed to air pollution. Methods: Sixty-one male Wistar rats were divided into eight groups: residual oil fly ash (ROFA) exposure and sedentary (ROFA-SED); ROFA exposure, sedentary and supplemented (ROFA-SEDCrPic); ROFA exposure and trained (ROFA-AT); ROFA exposure, supplemented and trained (ROFA-AT-CrPic); sedentary (Sal-SED); sedentary and supplemented (Sal-SED-CrPic); trained (Sal-AT); and supplemented and trained (Sal-AT-CrPic). Rats exposed to ROFA (air pollution) received 50 μg of ROFA daily via intranasal instillation. Supplemented rats received CrPic (1 mg/kg/day) daily by oral gavage. Exercise training was performed on a rat treadmill (5×/week). Oxidative parameters were evaluated at the end of protocols. Results: Trained groups demonstrated lower gain of body mass (P < .001) and increased exercise tolerance (P < .0001). In the gastrocnemius, trained groups demonstrated increased SOD activity (P < .0001) and decrease levels of TBARS (P = .0014), although CAT activity did not differ among groups (P = .4487). Conclusion: Air pollution exposure did not lead to alterations in oxidative markers in lungs and heart, and exercise training was responsible for decreasing oxidative stress of the gastrocnemius.

show abstract

Section: Discussionsupporting

confidence: 65%

“…First, animals were subjected to an adaptation period of five days and run for 10 min/day [28]. The test consisted of running on an electric treadmill with an inclination of 15°, starting with a speed of 5 m/min and increasing by an increment of 5 m/min every 3 min until exhaustion.…”

Section: Exercise Tolerance Testmentioning

confidence: 99%

Aerobic training reduces oxidative stress in skeletal muscle of rats exposed to air pollution and supplemented with chromium picolinate

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In accordance with the positive effects of exercise on Bdnf expression and memory formation, evidence shows that physical exercise alters SIRT1 dynamics in the brain. It was demonstrated that exercise increases SIRT1 activity in the hippocampus (Marton et al, 2016), and elevates its expression in various brain regions including cortex, hippocampus and hypothalamus (Steiner et al, 2011). Furthermore, in a recent study of the effects of physical exercise on the pathophysiology of Alzheimer's disease, the downregulation of SIRT1 in the cerebral cortex of 3xTgAD mice was attenuated by exercise treatment (Revilla et al, 2014).…”

Section: Exercise Influences Cognition Engaging Epigenetic Mechanimentioning

confidence: 99%

Physical exercise as an epigenetic modulator of brain plasticity and cognition

Fernandes

Arida

Gómez‐Pinilla

2017

Neuroscience & Biobehavioral Reviews

224

172

View full text Add to dashboard Cite

A large amount of evidence has demonstrated the power of exercise to support cognitive function, the effects of which can last for considerable time. An emerging line of scientific evidence indicates that the effects of exercise are longer lasting than previously thought up to the point to affect future generations. The action of exercise on epigenetic regulation of gene expression seem central to building an “epigenetic memory” to influence long-term brain function and behavior. In this review article, we discuss new developments in the epigenetic field connecting exercise with changes in cognitive function, including DNA methylation, histone modifications and microRNAs (miRNAs). The understanding of how exercise promotes long-term cognitive effects is crucial for directing the power of exercise to reduce the burden of neurological and psychiatric disorders.

show abstract

“…When controlling for amount of physical activity, female high-response rats still showed a higher rate of neurogenesis in hippocampus [23]. Moreover, the training at same intensity levels induced different responses in brain-derived neurotrophic factor (BDNF) in low-and high-response rats [24]. Thus, in animal models, inherent running capacity seemed to affect brain responses even though the exercise was similar between groups.…”

Section: Accepted Manuscript 1 Introductionmentioning

confidence: 99%

Aerobic fitness, but not physical activity, is associated with grey matter volume in adolescents

Ruotsalainen

Renvall

Gorbach

et al. 2019

Behavioural Brain Research

View full text Add to dashboard Cite

show abstract

The rate of training response to aerobic exercise affects brain function of rats

Cited by 9 publications

References 43 publications

Aerobic training reduces oxidative stress in skeletal muscle of rats exposed to air pollution and supplemented with chromium picolinate

Aerobic training reduces oxidative stress in skeletal muscle of rats exposed to air pollution and supplemented with chromium picolinate

Physical exercise as an epigenetic modulator of brain plasticity and cognition

Aerobic fitness, but not physical activity, is associated with grey matter volume in adolescents

Contact Info

Product

Resources

About