The rate of primary hypothyroidism in diabetic patients is greater than in the non-diabetic population. An observational study

Tamez-Pérez, Hector-Eloy; Martínez, Estebán; Quintanilla-Flores, Dania Lizet; Tamez-Peña, Alejandra Lorena; Gutiérrez-Hermosillo, Hugo; León-González, Enrique Díaz de

doi:10.1016/j.medcli.2011.08.009

Cited by 41 publications

(37 citation statements)

References 7 publications

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“…Prevalence of subclinical hypothyroidism is commonest disorder in this study (33.33%) which is similar to study by Perez et al 2011 36 and many other previous studies like Smithson et al, 37 Suzuki et al 38 and Celani et al 39 Anti TPO positivity has been found to be positive in 18.33% of total population which is consistent with most other studies, 40 22.22% in patients with thyroid dysfunction (most prevalent with subclinical hypothyroidism followed by overt hypothyroidism) and 6.67% in euthyroid patients. These findings are also consistent with previous study reported by Whitehead et al, Perros et al 41 (13.4%) and Papazafiropoulou (12.3%).…”

Section: Discussionsupporting

confidence: 92%

A study of prevalence of primary hypothyroidism in recently diagnosed type 2 diabetes mellitus in a tertiary care hospital

Mukherjee

Datta

et al. 2015

Int J Sci Rep

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Background: The association between thyroid dysfunction and DM has long been recognized, although the prevalence of thyroid dysfunction among diabetes population varies in different studies. This study destined to know the prevalence of thyroid dysfunction of recently diagnosed type 2 diabetes mellitus patients. Methods: Retrospective chart review of 60 patients with type 2 diabetes mellituswas done. Total 60 patients (male 51, female9) fulfillingdiagnostic criteria for diabetes mellitus according to ADA (American Diabetes Association) criteria were analysed by doing Thyroid Function Test (FT4,TSH).Results: 75% of patients have the biochemical features of thyroid dysfunction. Subcategorically in descending order of frequency they are - Subclinical hypothyroidism (33.33%) (defined by no symptoms or clinical fetures of hypothyroidism but biochemically TSH level in the range of above 5 mIU/ml but below 10 mIU/ml with normal FT4 level), 15% of patients each for overt hypothyroidism (either clinical features or Biochemically TSH >10 mIU/ml or FT4 below normal), and subclinical hyperthyroidism (only biochemical low level of TSH <0.34 mIU/ml in this study) and 11.667% patients show the features of clinical hyperthyroidism (clinical or FT4 level well above normal range along with low TSH).Conclusions: Avery high prevalence of thyroid dysfunction in this part of world in contrast to Europe & US suggest routine screening for thyroid disorder in recently diagnosed type 2 diabetes mellitus.

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Section: Discussionsupporting

confidence: 92%

A study of prevalence of primary hypothyroidism in recently diagnosed type 2 diabetes mellitus in a tertiary care hospital

Mukherjee

Datta

et al. 2015

Int J Sci Rep

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“…Concordant with the increase in anti-thyroid antibody level, primary hypothyroidism and the elevation of TSH, is 3 times more frequent in type 2 diabetics than in non-diabetics [56]. Even though the roles of TSH in thyroid carcinogenesis have not been established, there were several studies which reported the association of autonomous TSH regulation with reduction in thyroid cancer risk [57], or prediction of aggressive carcinoma of thyroid with higher TSH concentration [58].…”

Section: Discussionmentioning

confidence: 99%

Diabetes Mellitus and Risk of Thyroid Cancer: A Meta-Analysis

et al. 2014

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IntroductionDiabetes mellitus (DM) is an important risk factor for endocrine cancers; however, the association with thyroid cancer is not clear. We performed a systematic review and meta-analysis to clarify the association between thyroid cancer and DM.MethodsWe searched MEDLINE, PUBMED and EMBASE databases through July 2012, using search terms related to diabetes mellitus, cancer, and thyroid cancer. We conducted a meta-analysis of the risk of incidence of thyroid cancer from pre-existing diabetes. Of 2,123 titles initially identified, sixteen articles met our inclusion criteria. An additional article was identified from a bibliography. Totally, 14 cohort and 3 case-control studies were selected for the meta-analysis. The risks were estimated using random-effects model and sensitivity test for the studies which reported risk estimates and used different definition of DM.ResultsCompared with individuals without DM, the patients with DM were at 1.34-fold higher risk for thyroid cancer (95% CI 1.11–1.63). However, there was heterogeneity in the results (p<0.0001). Sensitivity tests and studies judged to be high quality did not show heterogeneity and DM was associated with higher risk for thyroid cancer in these sub-analyses (both of RRs = 1.18, 95% CIs 1.08–1.28). DM was associated with a 1.38-fold increased risk of thyroid cancer in women (95% CI 1.13–1.67) after sensitivity test. Risk of thyroid cancer in men did not remain significant (RR 1.11, 95% CI 0.80–1.53).ConclusionsCompared with their non-diabetic counterparts, women with pre-existing DM have an increased risk of thyroid cancer.

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“…19 In a systematic review and meta-analysis, it has been noticed that the prevalence of SCH was higher in patients with T2DM as compared to healthy controls (OR = 1.93); and the similar trend was observed with studies focused on overt hypothyroidism. 20 In a multivariable model study, hypothyroidism and subclinical hypothyroidism correlated with increased risk for diabetes (rate ratios, 1.53 and 1.75 respectively) among statin users and nonusers. 21 In the present study, it was observed that SCH in diabetics was more prevalent (15%) than it was found in healthy controls (5%).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of thyroid dysfunction and its association with controlled and uncontrolled type 2 diabetes mellitus in northern Andhra Pradesh population: a retrospective study

2017

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Background: The two important endocrinopathies, diabetes mellitus and thyroid dysfunction are interrelated to each other where the correlation is poorly understood. The thyroid dysfunction is more frequent in diabetics than general population. The present study was aimed to know the prevalence of thyroid dysfunction in type 2 diabetes mellitus (T2DM) and its association with controlled and uncontrolled T2DM.Methods: A retrospective study of 600 T2DM patients between 13-60 years of age with known thyroid status were included and the following parameters were examined: age, sex, body mass index (BMI), fasting blood sugar (FBS), HbA1C, free triiodothyronine (fT3), free tetraiodothyronine (fT4) and thyroid stimulating hormone (TSH).Results: The prevalence of thyroid dysfunction in T2DM patients was found to be 26.5% whereas 9% in healthy controls. Significantly elevated levels of FBS, HbA1C and TSH were observed whereas the levels of fT3, fT4 were found to be low in patients when compared to controls. Subclinical hypothyroidism (SCH) in diabetics (both controlled and uncontrolled) was more prevalent (15%) than it was found in healthy controls (5%). Similarly, overt hypothyroidism was also found to be high in diabetic patients (6%) as compared to healthy controls (2%). Significant difference (p <0.05) in the levels of TSH was found between group I (Controlled T2DM) and II (uncontrolled T2DM patients), also between groups II and III (Controls). Group II patients were found to have significant low levels of fT3 as compared to other two groups (Group I and III) (p<0.005).Conclusions: As SCH is more frequent in T2DM diabetes mellitus and untreated SCH patients have higher rate of complications, periodical screening is advised for thyroid dysfunction to prevent micro vascular and cardiovascular complications.

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The rate of primary hypothyroidism in diabetic patients is greater than in the non-diabetic population. An observational study

Cited by 41 publications

References 7 publications

A study of prevalence of primary hypothyroidism in recently diagnosed type 2 diabetes mellitus in a tertiary care hospital

A study of prevalence of primary hypothyroidism in recently diagnosed type 2 diabetes mellitus in a tertiary care hospital

Diabetes Mellitus and Risk of Thyroid Cancer: A Meta-Analysis

Prevalence of thyroid dysfunction and its association with controlled and uncontrolled type 2 diabetes mellitus in northern Andhra Pradesh population: a retrospective study

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