The Rate of Addiction in Parents of Toddlers With Congenital Heart Disease

Sahramian, Iraj; Noori, Noor Mohammad; Moradi, Abdolvahab; Forghani, Fereidoun; Sharafi, Elham

doi:10.5812/ijhrba.7312

Cited by 3 publications

(2 citation statements)

References 13 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The decrease in DNA synthesis and cardiac cell proliferation observed with endogenous OGF becomes exaggerated with maternal opioid use, causing a decrease in fetal heart rate and a rise in the incidence of congenital heart defects. 22,23,27,28 These findings indicate that opioid use during pregnancy can pose life-threatening dangers to the fetus or the newborn.…”

Section: Discussionmentioning

confidence: 95%

“…In a study analyzing 225 children with congenital heart defects, 23.5% had parents addicted to opioids, while only 2.3% of children with healthy hearts had parents with an opioid addiction. 28 In addition to opioid addiction, maternal use of opioids as analgesics to alleviate pain has also been linked to congenital heart defects. Analgesic opioid use in early pregnancy, ranging from 1 month before to 3 months after conception, was found to be significantly associated with increased incidence of pulmonary valve stenosis, hypoplastic left heart syndrome, atrial septal defect, conoventricular septal defect, atrioventricular septal defect, and tetralogy of Fallot.…”

Section: Georgetown Medical Reviewmentioning

confidence: 99%

See 1 more Smart Citation

The Effects of Opioids During Pregnancy: A Literature Review

Asdjodi

Rubarth

Hardy

et al. 2020

Georgetown Medical Review

View full text Add to dashboard Cite

The alarming increase in opioid use in the United States, particularly during pregnancy, over the past few decades underlines the need to thoroughly investigate the consequences of opioid use within the context of reproduction and development. Opioid exposure has been linked to a number of effects on the various physiologic processes involved in embryonic development. Opioids have been shown to hinder the preimplantation embryo from progressing into the blastocyst stage and implanting into the uterus. Maternal opioid use has also been shown to be neurotoxic to the embryo. Exogenous opioids negatively affect the somatosensory cortex, hippocampus, and cholinergic system in the developing embryo, leading to consequences ranging from poor memory function to learning disabilities. Additionally, opioids have the potential to negatively affect the embryonic heart. Opioid use has been shown to slow down the growth of cardiac tissue, decrease fetal heart rate, and increase the incidence of congenital heart defects. Through review of existing studies, we conclude that opioid use during pregnancy has a significant risk of being detrimental to the embryo. Based on the available scientific literature, we recommend reevaluating current guidelines on opioid use during pregnancy to ensure that opioid exposure to the embryo is limited as much as possible.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Georgetown Medical Reviewmentioning

confidence: 99%

The Effects of Opioids During Pregnancy: A Literature Review

Asdjodi

Rubarth

Hardy

et al. 2020

Georgetown Medical Review

View full text Add to dashboard Cite

show abstract

Epidemiology studies on effects of lithium salts in pregnancy are confounded by the inability to control for other potentially teratogenic factors

Smith,

Payne

2024

Hum Exp Toxicol

View full text Add to dashboard Cite

Introduction In bipolar women who took lithium during pregnancy, several epidemiology studies have reported small increases in a rare fetal cardiac defect termed Ebstein’s anomaly. Methods Behavioral, environmental, and lifestyle-associated risk factors associated with bipolar disorder and health insurance status were determined from an Internet search. The search was conducted from October 1, 2023, through October 14, 2023. The search terms employed included the following: bipolar, bipolar disorder, mood disorders, pregnancy, congenital heart defects, Ebstein’s anomaly, diabetes, hypertension, Medicaid, Medicaid patients, alcohol use, cigarette smoking, marijuana, cocaine, methamphetamine, narcotics, nutrition, diet, obesity, body mass index, environment, environmental exposures, poverty, socioeconomic status, divorce, unemployment, and income. No quotes, special fields, truncations, etc., were used in the searches. No filters of any kind were used in the searches. Results Women who remain on lithium in the United States throughout their pregnancy are likely to be experiencing mania symptoms and/or suicidal ideation refractory to other drugs. Pregnant women administered the highest doses of lithium salts would be expected to have been insufficiently responsive to lower doses. Any small increases in the retrospectively determined risk of fetal cardiac anomalies in bipolar women taking lithium salts cannot be disentangled from potential developmental effects resulting from very high rates of cigarette smoking, poor diet, alcohol abuse, ingestion of illegal drugs like cocaine or opioids, marijuana smoking, obesity, and poverty. Conclusions The small risks in fetal cardiac abnormalities reported in the epidemiology literature do not establish a causal association for lithium salts and Ebstein’s anomaly.

show abstract

Low-dose Computed Tomography (CT) for the Diagnosis of Congenital Heart Disease in Children: A Meta-analysis

Tian

Wang

Qin

et al. 2020

CMIR

View full text Add to dashboard Cite

Background: Low dose CT has become a promising examination method for the diagnosis of Congenital heart disease (CHD) in children because it has the low radiation dose, but it has not been widely accepted as an alternative to standard-dose CT in clinical applications due to concerns about image quality. Therefore, we suggest that the diagnostic accuracy, image quality, and radiation dose of low-dose CT for CHD in children should be fully explored through a meta-analysis of existing studies. Methods: A comprehensive search was performed to identify relevant English and Chinese articles (from inception to May 2019). All selected studies concerned the diagnosis of CHD in children using low-dose CT. The accuracy of low-dose CT was determined by calculating pooled estimates of sensitivity, specificity, diagnostic odds ratio, and likelihood ratio. Pooling was conducted using a bivariate generalized linear mixed model. Forest plots and summary receiver operating characteristic (SROC) curves were generated. Results: Ten studies, accounting for 577 patients, met the eligibility criteria. The pooled sensitivity and specificity were 0.95 (95% confidence interval (CI) 0.92-0.97) and 1.00 (95% CI 1.00-1.00), respectively. The pooled diagnostic odds ratio, positive likelihood ratio, and negative likelihood ratio of low-dose CT were 12705.53 (95% CI 5065.00-31871.73), 671.29 (95% CI 264.77-1701.97), and 0.05 (95% CI 0.03-0.08), respectively. Additionally, the area under the SROC curve was 1.00 (95% CI 0.99-1.00), suggesting that low-dose CT is an excellent diagnostic tool for CHD in children. Conclusion: Low-dose CT, especially with a prospective ECG-triggering mode, provides excellent imaging quality and high diagnostic accuracy for CHD in children.

show abstract

The Rate of Addiction in Parents of Toddlers With Congenital Heart Disease

Cited by 3 publications

References 13 publications

The Effects of Opioids During Pregnancy: A Literature Review

The Effects of Opioids During Pregnancy: A Literature Review

Epidemiology studies on effects of lithium salts in pregnancy are confounded by the inability to control for other potentially teratogenic factors

Low-dose Computed Tomography (CT) for the Diagnosis of Congenital Heart Disease in Children: A Meta-analysis

Contact Info

Product

Resources

About