The rat as an animal model for fetoplacental development: a reappraisal of the post-implantation period

Fonseca, Bruno M.; Correia-da-Silva, Georgina; Teixeira, Natércia

doi:10.1016/s1642-431x(12)60080-1

Cited by 67 publications

(50 citation statements)

References 78 publications

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“…Even though it is not the aim of this contribution to repeat the astonishing amount of data on mouse placentation, so far special reference has been given to the early establishment of the placenta, the associated genes and cell lineages, relevant knock out models, and in regard to common pregnancy disorders such as fetal miscarriage, preeclampsia, or intrauterine growth restriction (e.g., [18,70,71,[180][181][182][183][184][185][186][187][188][189][190][191][192][193][194]). Also, several studies deal with placental aspects in the laboratory rat Rattus norvegicus (e.g., [70,71,[195][196][197][198][199][200][201][202][203][204][205][206]). However, besides these truly important approaches there are also severe differences in comparison to the human placenta that are essential to understand as restrictions in using the mouse or rat as animal model.…”

Section: Euarchontogliresmentioning

confidence: 99%

Placental Evolution within the Supraordinal Clades of Eutheria with the Perspective of Alternative Animal Models for Human Placentation

Mess

2014

Advances in Biology

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Here a survey of placental evolution is conducted. Placentation is a key factor for the evolution of placental mammals that had evolved an astonishing diversity. As a temporary organ that does not allow easy access, it is still not well understood. The lack of data also is a restriction for better understanding of placental development, structure, and function in the human. Animal models are essential, because experimental access to the human placenta is naturally restricted. However, there is not a single ideal model that is entirely similar to humans. It is particularly important to establish other models than the mouse, which is characterised by a short gestation period and poorly developed neonates that may provide insights only for early human pregnancy. In conclusion, current evolutionary studies have contributed essentially to providing a pool of experimental models for recent and future approaches that may also meet the requirements of a long gestation period and advanced developmental status of the newborn in the human. Suitability and limitations of taxa as alternative animal models are discussed. However, further investigations especially in wildlife taxa should be conducted in order to learn more about the full evolutionary plasticity of the placenta system.

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Section: Euarchontogliresmentioning

confidence: 99%

Placental Evolution within the Supraordinal Clades of Eutheria with the Perspective of Alternative Animal Models for Human Placentation

Mess

2014

Advances in Biology

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“…4,5 More recently the rat has gained favor as a model of trophoblast invasion as it confers several advantages over the mouse in that the depth of trophoblast invasion follows a similar pattern to that observed in the human and trophoblasts also colonize the spiral arteries and contribute to their remodeling. [6][7][8] Finally, animal models allow the complex in vivo interactions between the trophoblast and endometrium to be examined, an aspect of trophoblast invasion that is particularly difficult to accurately replicate in vitro. Despite these advantages, it is important to remember that rodent placentation is anatomically distinct from human placentation, and thus it is important to relate findings from such animal models back to human trophoblast.…”

Section: Introductionmentioning

confidence: 99%

Quantifying trophoblast migration: In vitro approaches to address in vivo situations

James

Tun

Clark

2016

Cell Adhesion & Migration

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When trophoblasts migrate and invade in vivo, they do so by interacting with a range of other cell types, extracellular matrix proteins, chemotactic factors and physical forces such as fluid shear stress. These factors combine to influence overall trophoblast migration and invasion into the decidua, which in turn determines the success of spiral artery remodeling, and pregnancy itself. Our understanding of these important but complex processes is limited by the simplified conditions in which we often study cell migration in vitro, and many discrepancies are observed between different in vitro models in the literature. On top of these experimental considerations, the migration of individual trophoblasts can vary widely. While time-lapse microscopy provides a wealth of information on trophoblast migration, manual tracking of individual cell migration is a time consuming task that ultimately restricts the numbers of cells quantified, and thus the ability to extract meaningful information from the data. However, the development of automated imaging algorithms is likely to aid our ability to accurately interpret trophoblast migration in vitro, and better allow us to relate these observations to in vivo scenarios. This commentary discusses the advantages and disadvantages of techniques commonly used to quantify trophoblast migration and invasion, both from a cell biology and a mathematical perspective, and examines how such techniques could be improved to help us relate trophoblast migration more accurately to in vivo function in the future.

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“…Angiogenesis towards oxygen-rich blood is a critical element of placentation, and elevated carbon dioxide levels may disrupt the development of the placenta (Fonseca et a/., 2012). Due to these similarities between rats and humans, along with the potential for C02 to disrupt placentation, it is reasonable to accept the endpoint of fetal resorption as directly relevant in deriving an exposure limit for C0 2 • The observed adverse effects of the current study are likely due to the experimental variable of C0 2 concentration, leading to the use of the NOAEL of 2.5% as a point of departure for recommending a CEL.…”

Section: Discussionmentioning

confidence: 99%

The Prenatal Development Effects of Carbon Dioxide (CO2) Exposure in Rats (Rattus Norvegicus)

Howard¹,

Wong²,

Okolica³

et al. 2012

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The rat as an animal model for fetoplacental development: a reappraisal of the post-implantation period

Cited by 67 publications

References 78 publications

Placental Evolution within the Supraordinal Clades of Eutheria with the Perspective of Alternative Animal Models for Human Placentation

Placental Evolution within the Supraordinal Clades of Eutheria with the Perspective of Alternative Animal Models for Human Placentation

Quantifying trophoblast migration: In vitro approaches to address in vivo situations

The Prenatal Development Effects of Carbon Dioxide (CO2) Exposure in Rats (Rattus Norvegicus)

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