The Ras pathway and spindle assembly collide?

Segal, Marisa; Clarke, Duncan J.

doi:10.1002/bies.1044

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…Scd1 physically associates with Moe1, a factor that contributes to the inherent instability of microtubules and is required for proper spindle function. Defects in both Ras1 and Scd1 lead to genome instability (Segal and Clarke 2001 ). Recent studies have implicated two other pathways that contribute to the regulation of accurate chromosome segregation: Chk1/Wat1-dependent regulation of the mitotic spindle microtubule structure (Verma et al.…”

Section: Division Abnormalitiesmentioning

confidence: 99%

Genetic instability in budding and fission yeast—sources and mechanisms

Skoneczna

Kaniak

Skoneczny

2015

FEMS Microbiology Reviews

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Cells are constantly confronted with endogenous and exogenous factors that affect their genomes. Eons of evolution have allowed the cellular mechanisms responsible for preserving the genome to adjust for achieving contradictory objectives: to maintain the genome unchanged and to acquire mutations that allow adaptation to environmental changes. One evolutionary mechanism that has been refined for survival is genetic variation. In this review, we describe the mechanisms responsible for two biological processes: genome maintenance and mutation tolerance involved in generations of genetic variations in mitotic cells of both Saccharomyces cerevisiae and Schizosaccharomyces pombe. These processes encompass mechanisms that ensure the fidelity of replication, DNA lesion sensing and DNA damage response pathways, as well as mechanisms that ensure precision in chromosome segregation during cell division. We discuss various factors that may influence genome stability, such as cellular ploidy, the phase of the cell cycle, transcriptional activity of a particular region of DNA, the proficiency of DNA quality control systems, the metabolic stage of the cell and its respiratory potential, and finally potential exposure to endogenous or environmental stress.

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Section: Division Abnormalitiesmentioning

confidence: 99%

Genetic instability in budding and fission yeast—sources and mechanisms

Skoneczna

Kaniak

Skoneczny

2015

FEMS Microbiology Reviews

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“…This specific localization is important for Ras signal transduction, as mislocalization of a constitutively activated Ras2p abrogates activated Ras2p phenotypes [22]. In the fission yeast, Schizosaccharomyces pombe , the sole Ras homolog, Ras1p, controls aspects of actin and microtubule assembly [23]. Therefore, Ras1p plays a major role in regulating cell morphology and size.…”

Section: Introductionmentioning

confidence: 99%

“…Ras1p also interacts with Scd1p, a putative GEF for Cdc42p [34]. Through Scd1p, Ras1p controls cytoskeletal change and cell shape likely by modulation of Cdc42p activity levels [23]. In S. pombe , Ras1p activity is positively regulated by two known GEFs, Ste6p and Efc25p, and as in S. cerevisiae , localization of the Ras1p is important for its regulation.…”

Section: Introductionmentioning

confidence: 99%

Ras-Mediated Signal Transduction and Virulence in Human Pathogenic Fungi

Fortwendel¹

2012

Fungal Genom Biol

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Signal transduction pathways regulating growth and stress responses are areas of significant study in the effort to delineate pathogenic mechanisms of fungi. In-depth knowledge of signal transduction events deepens our understanding of how a fungal pathogen is able to sense changes in the environment and respond accordingly by modulation of gene expression and re-organization of cellular activities to optimize fitness. Members of the Ras protein family are important regulators of growth and differentiation in eukaryotic organisms, and have been the focus of numerous studies exploring fungal pathogenesis. Here, the current data regarding Ras signal transduction are reviewed for three major pathogenic fungi: Cryptococcus neoformans, Candida albicans and Aspergillus fumigatus. Particular emphasis is placed on Ras-protein interactions during control of morphogenesis, stress response and virulence.

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Oncogenes in thyroid cancer

et al. 2003

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There have been significant advances in our understanding of carcinogenesis at the molecular level over the last 25 years. Oncogenes are of major interest as part of our search for knowledge surrounding the aetiology of cancer. There are several oncogenes associated with thyroid cancer. Detailed investigation of the nature and function of these tumour genes has provided important insights into both the tumour biology and the complex biochemical pathways of normal cellular functioning. Our knowledge of oncogene biology offers the hope of better diagnostic, therapeutic and prognostic modalities in our fight against this and other common cancers. Development of specific thyroid tumour markers and gene therapy is now a realistic prospect to supplement our present armamentarium of surgery and radiotherapy. This review aims to outline the pertinent information gained so far from studies of these oncogenes and provides both clinical relevance and fuel for further interest amongst the ENT thyroid community in this exciting area of research.

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The Ras pathway and spindle assembly collide?

Cited by 4 publications

References 23 publications

Genetic instability in budding and fission yeast—sources and mechanisms

Genetic instability in budding and fission yeast—sources and mechanisms

Ras-Mediated Signal Transduction and Virulence in Human Pathogenic Fungi

Oncogenes in thyroid cancer

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