Abstract:Oncogenic mutated Ras is a
key player in cancer, but despite intense and expensive approaches its
catalytic center seems undruggable. The Ras dimer interface is a possible
alternative drug target. Dimerization at the membrane affects cell growth
signal transduction. <i>In vivo</i> studies indicate
that preventing dimerization of oncogenic mutated Ras inhibits uncontrolled
cell growth. Conventional computational drug-screening approaches require a
precise atomic dimer model as input to successfully … Show more
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