The rare-earth yttrium induces cell apoptosis and autophagy in the male reproductive system through ROS-Ca2+-CamkII/Ampk axis

Hou, Fangpeng; Huang, Junyun; Qing, Furong; Guo, T.F.; Ouyang, Sijia; Tang, Xiaodong; Ding, Ye; Yu, Jingge; Li, Y.X.; Liu, Xia; He, Tian‐Sheng; Fan, Xin; Liu, Zhiping

doi:10.1016/j.ecoenv.2023.115262

Cited by 6 publications

(3 citation statements)

References 54 publications

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“…Cleaved-caspase-3 is central to the process of apoptosis, and p-MLKL is the marker of cell necrosis. 48 The results suggested that the increased cleaved-caspase-3 and p-MLKL were found in both the Ce6+laser group and ChS-Ce6+laser group, indicating the presence of cell apoptosis and necrosis after PDT. Especially, more significant changes of cleaved-caspase-3 and p-MLKL were found in the Ce6+laser group than those in the ChS-Ce6+laser group, demonstrating that apoptosis and necrosis played a more important role in nontargeted PDT.…”

Section: Resultsmentioning

confidence: 86%

“…We further examined the protein levels of molecules associated with apoptosis and necrosis (Supporting Figure 14). Cleaved-caspase-3 is central to the process of apoptosis, and p-MLKL is the marker of cell necrosis . The results suggested that the increased cleaved-caspase-3 and p-MLKL were found in both the Ce6+laser group and ChS-Ce6+laser group, indicating the presence of cell apoptosis and necrosis after PDT.…”

Section: Results and Discussionmentioning

confidence: 89%

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Golgi Apparatus-Targeted Photodynamic Therapy for Enhancing Tumor Immunogenicity by Eliciting NLRP3 Protein-Dependent Pyroptosis

Hu,

Wang,

Zhou

et al. 2023

ACS Nano

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Innate and adaptive immunity is important for initiating and maintaining immune function. The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome serves as a checkpoint in innate and adaptive immunity, promoting the secretion of pro-inflammatory cytokines and gasdermin D-mediated pyroptosis. As a highly inflammatory form of cell death distinct from apoptosis, pyroptosis can trigger immunogenic cell death and promote systemic immune responses in solid tumors. Previous studies proposed that NLRP3 was activated by translocation to the mitochondria. However, a recent authoritative study has challenged this model and proved that the Golgi apparatus might be a prerequisite for the activation of NLRP3. In this study, we first developed a Golgi apparatus-targeted photodynamic strategy to induce the activation of NLRP3 by precisely locating organelles. We found that Golgi apparatus-targeted photodynamic therapy could significantly upregulate NLRP3 expression to promote the subsequent release of intracellular proinflammatory contents such as IL-1β or IL-18, creating an inflammatory storm to enhance innate immunity. Moreover, this acute NLRP3 upregulation also activated its downstream classical caspase-1-dependent pyroptosis to enhance tumor immunogenicity, triggering adaptive immunity. Pyroptosis eventually led to immunogenic cell death, promoted the maturation of dendritic cells, and effectively activated antitumor immunity and long-lived immune memory. Overall, this Golgi apparatus-targeted strategy provided molecular insights into the occurrence of immunogenic pyroptosis and offered a platform to remodel the tumor microenvironment.

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Section: Resultsmentioning

confidence: 86%

Section: Results and Discussionmentioning

confidence: 89%

Golgi Apparatus-Targeted Photodynamic Therapy for Enhancing Tumor Immunogenicity by Eliciting NLRP3 Protein-Dependent Pyroptosis

Hu,

Wang,

Zhou

et al. 2023

ACS Nano

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“…RE NMs can enter the human body through inhalation, oral ingestion, and dermal contact [ 211 – 215 ]. They accumulate mainly in bone, liver, and spleen [ 29 , 216 , 217 ], giving rise to various toxic effects such as neurodegeneration [ 218 , 219 ], damage to the reproductive system [ 220 ] and hemolysis [ 193 ].…”

Section: Prospects and Limitationsmentioning

confidence: 99%

Systematic review of the osteogenic effect of rare earth nanomaterials and the underlying mechanisms

Chen,

Zhou,

et al. 2024

J Nanobiotechnol

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Rare earth nanomaterials (RE NMs), which are based on rare earth elements, have emerged as remarkable biomaterials for use in bone regeneration. The effects of RE NMs on osteogenesis, such as promoting the osteogenic differentiation of mesenchymal stem cells, have been investigated. However, the contributions of the properties of RE NMs to bone regeneration and their interactions with various cell types during osteogenesis have not been reviewed. Here, we review the crucial roles of the physicochemical and biological properties of RE NMs and focus on their osteogenic mechanisms. RE NMs directly promote the proliferation, adhesion, migration, and osteogenic differentiation of mesenchymal stem cells. They also increase collagen secretion and mineralization to accelerate osteogenesis. Furthermore, RE NMs inhibit osteoclast formation and regulate the immune environment by modulating macrophages and promote angiogenesis by inducing hypoxia in endothelial cells. These effects create a microenvironment that is conducive to bone formation. This review will help researchers overcome current limitations to take full advantage of the osteogenic benefits of RE NMs and will suggest a potential approach for further osteogenesis research. Graphical abstract

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Environmental endocrine disrupting chemical 4-tert-butylphenol induced calcium overload and subsequent autophagy impairment via miRNA-363/CACNA1D Axis in epithelioma papulosum cyprini cells

Cui,

Liang,

Liu

et al. 2024

Comparative Biochemistry and Physiology Part C: Toxicology &

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The rare-earth yttrium induces cell apoptosis and autophagy in the male reproductive system through ROS-Ca2+-CamkII/Ampk axis

Cited by 6 publications

References 54 publications

Golgi Apparatus-Targeted Photodynamic Therapy for Enhancing Tumor Immunogenicity by Eliciting NLRP3 Protein-Dependent Pyroptosis

Golgi Apparatus-Targeted Photodynamic Therapy for Enhancing Tumor Immunogenicity by Eliciting NLRP3 Protein-Dependent Pyroptosis

Systematic review of the osteogenic effect of rare earth nanomaterials and the underlying mechanisms

Environmental endocrine disrupting chemical 4-tert-butylphenol induced calcium overload and subsequent autophagy impairment via miRNA-363/CACNA1D Axis in epithelioma papulosum cyprini cells

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