The rapid quantitative analysis of codeine phosphate drug substance by reversed-phase high-performance liquid chromatography

Sisco, W.R.; Rittenhouse, C. T.; Maggio, W. M.

doi:10.1007/bf02310385

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…The literature survey reveals that many analytical methods are reported for the determination of CP and CPM indi-vidually and in combination. The literature survey revealed spectroscopic [2][3][4][5] and chromatographic [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] methods.…”

Section: Introductionmentioning

confidence: 99%

Validated Stability Indicating RP-HPLC Method for Simultaneous Estimation of Codeine Phosphate and Chlorpheniramine Maleate from Their Combined Liquid Dosage Form

Kommana¹,

Basappa²

2013

Chromatography Research International

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The present paper describes the development of quick stability indicating RP-HPLC method for the simultaneous estimation of codeine phosphate and chlorpheniramine maleate in the presence of its degradation products, generated from forced degradation studies. The developed method separates codeine phosphate and chlorpheniramine maleate in impurities/degradation products. Codeine phosphate and chlorpheniramine maleate and their combination drug product were exposed to acid, base, oxidation, dry heat, and photolytic stress conditions, and the stressed samples were analysed by proposed method. The proposed HPLC method utilizes the Shimadzu HPLC system on a Phenomenex C 18 column (250 mm × 4.6 mm, 5 ) using a mixture of 1% o-phosphoric acid in water : acetonitrile : methanol (78 : 10 : 12) mobile phase with pH adjusted to 3.0 in an isocratic elution mode at a flow rate of 1 mL/min, at 23 ∘ C with a load of 20 L. The detection was carried out at 254 nm. The retention time of codeine phosphate and chlorpheniramine maleate was found to be around 3.47 min and 9.45 min, respectively. The method has been validated with respect to linearity, robustness, precision, accuracy, limit of detection (LOD), and limit of quantification (LOQ). The developed validated stability indicating HPLC method was found to be simple, accurate, and reproducible for the determination of instability of these drugs in bulk and commercial products.

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Section: Introductionmentioning

confidence: 99%

Validated Stability Indicating RP-HPLC Method for Simultaneous Estimation of Codeine Phosphate and Chlorpheniramine Maleate from Their Combined Liquid Dosage Form

Kommana¹,

Basappa²

2013

Chromatography Research International

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“…The most commonly used detection system is UV absorption at a variety of fixed wavelengths: 220nm (Evren et al, 1985), 254 nm (Beasley et al, 1974;Akhila and Uniyal, 1983;Sisco et al, 1985;Srivastava and Maheshwari, 1985;Ayyangar and Bhide, 1986), and 280 nm Galewsky and Nessler, 1984;Ayyangar and Bhide, 1988), or at variable wavelengths within a given range (Doner and Hsu, 1982; Dogan ef a(., 1986). Variable-wavelength detectors are suitable for detecting nearly all the alkaloids in this group (Billiet etuf., 1986;Janicot et al, 1988;Verma et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Analysis of poppy straw and poppy straw concentrate by reversed‐phase high‐performance liquid chromatography

Gómez-Serranillos

Carretero

Villar

1994

Phytochemical Analysis

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A method of reversed‐phase high‐performance liquid chromatography using an elution gradient has been developed to analyse morphine, codeine, thebaine, and oripavine — this last‐mentioned substance for the first time — in samples of poppy straw and poppy straw concentrate. Gradient elution of the octadecylsilane column was performed: the gradient was from 10 to 30% of solvent A (methanol) in solvent B (containing 67% of 0.5% aqueous ammonium acetate solution containing diethylamine, and 33% of methanol) over a 25 min period. The four alkaloids were identified and quantified with the aid of an internal standard.

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Kinetic determination of codeine in pharmaceutical preparations

Milovanović

Trifković²,

Janjić³

1986

Mikrochim Acta

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The rapid quantitative analysis of codeine phosphate drug substance by reversed-phase high-performance liquid chromatography

Cited by 7 publications

References 12 publications

Validated Stability Indicating RP-HPLC Method for Simultaneous Estimation of Codeine Phosphate and Chlorpheniramine Maleate from Their Combined Liquid Dosage Form

Validated Stability Indicating RP-HPLC Method for Simultaneous Estimation of Codeine Phosphate and Chlorpheniramine Maleate from Their Combined Liquid Dosage Form

Analysis of poppy straw and poppy straw concentrate by reversed‐phase high‐performance liquid chromatography

Kinetic determination of codeine in pharmaceutical preparations

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