The Rapid Assessment of Disease Activity in Rheumatology (Radar) Questionnaire

Mason, John H.; Anderson, Jennifer J.; Meenan, Robert F.; Haralson, Kathleen M.; Lewis-Stevens, Donna; Kaine, Jeffrey

doi:10.1002/art.1780350206

Cited by 123 publications

(38 citation statements)

References 9 publications

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“…Physicians recorded affected joint scores and numbers and overall disease activity. Self-assessment by patients was performed by using the Rapid Assessment of Disease Activity in Rheumatology (24). Both physician-and patient-generated data showed a marked improvement from baseline.…”

Section: Resultsmentioning

confidence: 99%

Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis

Prakken

Samodal

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

202

157

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Modulation of epitope-specific immune responses would represent a major addition to available therapeutic options for many autoimmune diseases. The objective of this work was to induce immune deviation by mucosal peptide-specific immunotherapy in rheumatoid arthritis (RA) patients, and to dissect the related immunological mechanisms by using a technology for the detection of low-affinity class II-restricted peptide-specific T cells. A group of patients with early RA was treated for 6 months orally with dnaJP1, a peptide that induces proinflammatory T cell responses in naive RA patients. Immunological analysis at initial, intermediate and end treatment points showed an intriguing change from proinflammatory to regulatory T cell function. In fact, dnaJP1-induced T cell production of IL-4 and IL-10 increased significantly when initial and end treatment points were compared, whereas dnaJP1-induced T cell proliferation and production of IL-2, IFN-␥, and tumor necrosis factor-␣ decreased significantly. The total number of dnaJP1-specific cells did not change over time, whereas expression of foxP3 by CD4 ؉ CD25 bright cells increased, suggesting that the treatment affected regulatory T cell function. Thus, rather than clonal deletion, the observed change in immune reactivity to dnaJP1 was the outcome of treatment-induced emergence of T cells with a different functional phenotype. This study contributes to our knowledge of mechanisms and tools needed for antigen-specific immune modulation in humans, thus laying the foundation for exploitation of this approach for therapeutic purposes.

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Section: Resultsmentioning

confidence: 99%

Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis

Prakken

Samodal

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

202

157

View full text Add to dashboard Cite

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“…23 Separate ratings made for each of 20 joints or joint groups (from 0 ϭ no joint pain or tenderness to 3 ϭ severe joint pain or tenderness) were summed for analysis. The within-person internal consistency of this scale was .88.…”

Section: Daily Joint Painmentioning

confidence: 99%

A Comparison of Conventional Pain Coping Skills Training and Pain Coping Skills Training With a Maintenance Training Component: A Daily Diary Analysis of Short- and Long-Term Treatment Effects

Carson

Keefe

Affleck

et al. 2006

The Journal of Pain

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“…Functions related to movements of lower extremities have been suggested to play an important role in RA patients' disability [18,19]. However, the ROAD questionnaire development suggested that upper extremity functions explain most of the variance.…”

Section: Realtive Importance Of Functions 8 Discussionmentioning

confidence: 99%

Relative importance of the functional abilities comprising Health Assessment Questionnaire Disability Index among rheumatoid arthritis patients

et al. 2009

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Objectives: To evaluate the relative importance of the twenty functions assessed by patients to produce the Health Assessment Questionnaire's Disability Index (HAQ-DI).Methods: A systematic sample of 242 rheumatoid arthritis patients was drawn. Altogether 179 subjects returned acceptably filled questionnaire including perceived rheumatoid arthritis status in the 20 functions comprising the HAQ-DI. A separate complementary questionnaire was sent to 80 randomly chosen subjects. They were asked to estimate how important each of the same twenty items were in their everyday life by using the VAS method. Completely answered complementary questionnaires were returned by 66 (88%) of the subsample.Results: The relative importance of the functions assessed varied considerably. Men assessed the highest importance to the ability to walk outdoors on flat ground and women to dressing themselves, getting in and out of bed and washing and drying their body. For both genders the least important function was the ability to take a tub bath. The importance of all other functions except taking a tub bath were positively highly significantly correlated with the importance of each of the other functions. Factor analyses with one factor model showed high loadings on most functions, with the exception of 'Take a tub bath'. The two factor model formed one factor with loadings concentrating slightly more on 'lower extremity' and another on 'upper extremity'.Conclusions: Assessment of RA patients' functional status would benefit from further development of measures by giving relative weights from patients' perspective to those functional abilities which are used for index computations.

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The Rapid Assessment of Disease Activity in Rheumatology (Radar) Questionnaire

Abstract: Objective. This study documents the measurement properties of a brief, self-administered questionnaire of disease signs and symptoms in patients with rheumatoid arthritis. Measurement of disease signs and symptoms is a key aspect of outcome evaluation in rheumatology-

Cited by 123 publications

References 9 publications

Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis

Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis

A Comparison of Conventional Pain Coping Skills Training and Pain Coping Skills Training With a Maintenance Training Component: A Daily Diary Analysis of Short- and Long-Term Treatment Effects

Relative importance of the functional abilities comprising Health Assessment Questionnaire Disability Index among rheumatoid arthritis patients

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