The Range of Normal Values of Cardiovascular Structures in Infants, Children, and Adolescents Measured by Magnetic Resonance Imaging

Lorenz, Christine H.

doi:10.1007/s002469910006

Cited by 110 publications

(79 citation statements)

References 38 publications

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“…Currently, normal values from small studies employing gradient-echo MRI sequences are used (2,3). In recent years, however, steady-state free precession (SSFP) gradient echo sequences have become the standard method for assessment of ventricular function and volumetric parameters with CMR imaging (1).…”

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confidence: 99%

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Normal biventricular function, volumes, and mass in children aged 8 to 17 years

Robbers‐Visser

Boersma

Helbing

2009

Magnetic Resonance Imaging

106

112

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Purpose: To assess normal values for biventricular function, volumes, and mass with current cardiovascular magnetic resonance (CMR) imaging sequences in children. Materials and Methods:Included in the study were 60 healthy children aged 8 -17 years. A short axis set of contiguous slices was acquired with CMR imaging employing steady-state free precession. Biventricular end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), and mass were determined. Uni-and multivariate linear regression analyses were performed to study the interrelation of age, gender, and body surface area (BSA) on biventricular volumes and mass. The coefficient of variation was calculated for intra-and interobserver variability.Results: EF did not differ between boys and girls (mean LV-EF 69 Ϯ (SD) 5%, mean RV-EF 65 Ϯ 5%). BSA had good (EDV, mass) and modest (ESV) correlation with biventricular measurements. Gender appeared a significant modifier of these relations, whereas age had no independent contribution. The intra-and interobserver coefficient of variation was in the range 2.1%-13.9% for biventricular EDV, ESV, and mass. Conclusion:This study reveals gender-specific normative data for biventricular function, volumes, and mass in children age 8 -17 years that can be used as reference data in the follow-up of pediatric cardiac patients.

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confidence: 99%

“…Besides different MRI sequences, the few studies measuring ventricular function, volumes, and mass in small groups of healthy children have used different acquisition techniques (free breathing instead of breath-hold techniques, different image orientation) than are commonly used in a clinical setting nowadays (2,3).…”

mentioning

confidence: 99%

Normal biventricular function, volumes, and mass in children aged 8 to 17 years

Robbers‐Visser

Boersma

Helbing

2009

Magnetic Resonance Imaging

106

112

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“…Normal values for main pulmonary artery (MPA) diameters are only available for children, 4 and the prevalence of MPA dilatation has only been assessed with magnetic resonance imaging (MRI) in patients with MFS. 5 A few reports on normal values for the diameters of the descending thoracic or abdominal aorta are available, 6,7 but these have not yet been evaluated systematically in patients with MFS.…”

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confidence: 99%

A critical analysis of minor cardiovascular criteria in the diagnostic evaluation of patients with Marfan syndrome

Backer¹,

Loeys²,

Devos

et al. 2006

Genetics in Medicine

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Purpose: The prevalence of most minor cardiovascular manifestations in Marfan syndrome (MFS) is unknown. We assessed the prevalence of minor cardiovascular manifestations in MFS to evaluate their usefulness in a diagnostic setting. Methods: Seventy-seven patients with MFS (aged 4 months to 55 years) underwent echocardiography to assess the presence of mitral valve prolapse and the diameter of the main pulmonary artery. A subset of 29 adult patients with MFS also underwent magnetic resonance imaging evaluation of the diameters of the thoracoabdominal aorta. Results:Mitral valve prolapse was encountered in 66% of patients with MFS, with an equal distribution of classic and nonclassic mitral valve prolapse. The main pulmonary artery diameter was significantly larger in patients with MFS at all ages when compared with controls. In the adult group (Ն14 years), we were able to provide a cutoff value of 23 mm to define pulmonary artery dilatation. The descending aorta was enlarged, but with substantial overlap with controls, thus precluding the use of a cutoff value. Conclusions: Mitral valve prolapse and main pulmonary artery dilatation are common findings in MFS patients at all ages and are easy to assess with echocardiography. Cutoff values to define dilatation of the descending aorta are hard to define, making them of limited value in the diagnostic evaluation. We recommend echocardiographic evaluation of mitral valve proplase and main pulmonary artery diameter in patients referred for cardiovascular diagnostic assessment for MFS. Genet Med 2006:8(7):401-408.

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“…Normalized clinical parameters (mean ± standard deviation) values with respect to body surface area (BSA) using the proposed method, manual contours compared to the reference normal values for children [44].…”

Section: Tablementioning

confidence: 99%

“…Manual Normal values [44] RVEDV/BSA (ml/m 2 ) N/A 124.5 ± 29.5 70 ± 11 RVSV/BSA (ml/m 2 ) 38 ± 10 53 ± 10 43 ± 7 RVEF 0.35 ± 0.10 0.44 ± 0.10 N/A lower than the reference normal value. Also, the standard deviation values are higher than the reference normal values.…”

Section: Measurementmentioning

confidence: 99%

Right ventricular segmentation in cardiac MRI with moving mesh correspondences

Punithakumar

Noga

Ayed

et al. 2015

Computerized Medical Imaging and Graphics

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a b s t r a c tThis study investigates automatic propagation of the right ventricle (RV) endocardial and epicardial boundaries in 4D (3D+time) magnetic resonance imaging (MRI) sequences. Based on a moving mesh (or grid generation) framework, the proposed algorithm detects the endocardium and epicardium within each cardiac phase via point-to-point correspondences. The proposed method has the following advantages over prior RV segmentation works: (1) it removes the need for a time-consuming, manually built training set; (2) it does not make prior assumptions as to the intensity distributions or shape; (3) it provides a sequence of corresponding points over time, a comprehensive input that can be very useful in cardiac applications other than segmentation, e.g., regional wall motion analysis; and (4) it is more flexible for congenital heart disease where the RV undergoes high variations in shape. Furthermore, the proposed method allows comprehensive RV volumetric analysis over the complete cardiac cycle as well as automatic detections of end-systolic and end-diastolic phases because it provides a segmentation for each time step. Evaluated quantitatively over the 48-subject data set of the MICCAI 2012 RV segmentation challenge, the proposed method yielded an average Dice score of 0.84 ± 0.11 for the epicardium and 0.79 ± 0.17 for the endocardium. Further, quantitative evaluations of the proposed approach in comparisons to manual contours over 23 infant hypoplastic left heart syndrome patients yielded a Dice score of 0.82 ± 0.14, which demonstrates the robustness of the algorithm.

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The Range of Normal Values of Cardiovascular Structures in Infants, Children, and Adolescents Measured by Magnetic Resonance Imaging

Cited by 110 publications

References 38 publications

Normal biventricular function, volumes, and mass in children aged 8 to 17 years

Normal biventricular function, volumes, and mass in children aged 8 to 17 years

A critical analysis of minor cardiovascular criteria in the diagnostic evaluation of patients with Marfan syndrome

Right ventricular segmentation in cardiac MRI with moving mesh correspondences

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