The ramifications of HLA-B27

Sheehan, N. J.

doi:10.1258/jrsm.97.1.10

Cited by 73 publications

(36 citation statements)

References 35 publications

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“…It is estimated to be present in 75–95% of cases of ankylosing spondylitis (AS) and 42–75%1–6 of cases of axial non-radiographic/undifferentiated SpA. Its diagnostic importance is reflected by the inclusion of HLA-B27 in the Amor criteria for spondyloarthropathy in 19907 and in the Assessment of SpondyloArthritis international Society (ASAS) classification criteria8 9 for axial SpA in 2009.…”

Section: Introductionmentioning

confidence: 99%

HLA-B27 positive patients differ from HLA-B27 negative patients in clinical presentation and imaging: results from the DESIR cohort of patients with recent onset axial spondyloarthritis

Chung

Machado

Heijde

et al. 2011

Annals of the Rheumatic Diseases

138

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Section: Introductionmentioning

confidence: 99%

HLA-B27 positive patients differ from HLA-B27 negative patients in clinical presentation and imaging: results from the DESIR cohort of patients with recent onset axial spondyloarthritis

Chung

Machado

Heijde

et al. 2011

Annals of the Rheumatic Diseases

138

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“…Similarly in PD patients, not only are serum and lesional levels of TGF‐β1 elevated [42,44] but they seem to play an active role in the pathogenesis of fibrosis [44]. Likewise, up to 30% of patients affected by psoriasis will develop psoriatic arthritis [45], and about half of those affected by psoriatic arthritis carry HLA‐B27 [46]. As aforementioned, Ralph et al.…”

Section: Discussionmentioning

confidence: 99%

Peyronie's Disease and Autoimmunity—A Real-Life Clinical Study and Comprehensive Review

Ventimiglia

Capogrosso

Colicchia

et al. 2015

The Journal of Sexual Medicine

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Introduction Although heavily investigated over the last decades, Peyronie's disease (PD) pathogenesis remains unclear. Aim We sought to investigate the association between PD and autoimmune diseases (ADs) in men seeking medical help for sexual dysfunction in the real-life setting. Methods Complete sociodemographic and clinical data from a homogenous cohort of 1,140 consecutive Caucasian–European men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index and ADs were stratified according to International Classification of Diseases, Ninth Revision classification. Main Outcome Measures Descriptive statistics and multivariate logistic regression models tested the association between ADs and PD. Results PD was diagnosed in 148 (13%) of the 1,140 men; of PD patients, 14 (9.5%) had a comorbid AD; conversely, the rate of ADs in non-PD patients was significantly lower (χ2 = 24.7; P < 0.01). Both patient age and AD comorbidity achieved multivariable independent predictor status for PD (odds ratio [OR]: 1.05; P < 0.01 and OR: 4.90; P < 0.01, respectively). Conclusions Our observational findings showed that ADs are highly comorbid with PD in a large cohort of same-race individuals seeking medical help for sexual dysfunction in the real-life setting.

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“…In addition to genetic factors, immune disorders and systemic inflammation of the body are related to spondyloarthropathy. Furthermore, some research has confirmed that HLA-B27 is associated with other immune system and inflammatory diseases, such as psoriasis (Sheehan, 2004), acute anterior uveitis (Chang et al, 2005), and Crohn's disease (Purrmann et al, 1988;Khan, 1989).…”

Section: Validation Through Gwas Omim and Text Miningmentioning

confidence: 99%

Relationship of common expression quantitative trait loci genes to the immune system

Wang²,

Li³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Tissue-specific expression quantitative trait loci (eQTLs) are always linked to specific diseases. In this study, we focused on eQTLs common to multiple tissues and explored their functional mechanisms in disease for the first time. We found 11 common eQTL genes among multiple tissues. Five genes were validated through a genome-wide association study, 3 genes were validated using the Online Mendelian Inheritance in Man database, and the others were validated through text mining. Most of these disorders were related to the systemic immune system. In functional analyses using Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes, these common eQTL genes were enriched in biological processes and pathways mostly related to the 6547 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (4): 6546-6553 (2013) Common eQTLs related to the immune system immunity. Therefore, we believe that these common eQTL genes are related to immune system.

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The ramifications of HLA-B27

Cited by 73 publications

References 35 publications

HLA-B27 positive patients differ from HLA-B27 negative patients in clinical presentation and imaging: results from the DESIR cohort of patients with recent onset axial spondyloarthritis

HLA-B27 positive patients differ from HLA-B27 negative patients in clinical presentation and imaging: results from the DESIR cohort of patients with recent onset axial spondyloarthritis

Peyronie's Disease and Autoimmunity—A Real-Life Clinical Study and Comprehensive Review

Relationship of common expression quantitative trait loci genes to the immune system

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