The Raf/LIN-45 C-terminal distal tail segment negatively regulates signaling in Caenorhabditis elegans
Robert A Townley,
Kennedy S Stacy,
Fatemeh Cheraghi
et al.
Abstract:Raf protein kinases act as Ras-GTP sensing components of the ERK signal transduction pathway in animal cells, influencing cell proliferation, differentiation, and survival. In humans, somatic and germline mutations in the genes BRAF and RAF1 are associated with malignancies and developmental disorders. Recent studies shed light on the structure of activated Raf, a heterotetramer consisting of Raf and 14-3-3 dimers, and raised the possibility that a Raf C-terminal distal tail segment (DTS) regulates activation.… Show more
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