The Radish, Raphanus sativus L. Var. caudatus reduces anxiety-like behavior in mice

Siddiq, Afshan; Younus, Ishrat

doi:10.1007/s11011-018-0240-4

Cited by 9 publications

(9 citation statements)

References 17 publications

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“…The dosing was done once daily according to the bodyweight for a continuous 60 days. The doses for test groups were selected on the basis of Acute toxicity testing OECD guidelines 423 as mentioned in our previously reported study (10). All the neuropharmacological tests were conducted between 8 am to 4 pm.…”

Section: Grouping and Dosingmentioning

confidence: 99%

Neuropharmacological Evaluation of Sedative and Muscle Relaxant Properties of Raphanus Caudatus in Albino Mice

Younus¹,

Siddiq²,

Sadaf³

2019

Acta Poloniae Pharmaceutica - Drug Research

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Vegetables are of great importance because they are not only used as food rather they also play a fundamental role in the prevention and treatment of different illnesses. They are a rich source of vitamins, minerals, amino acids, antioxidants and fibers thus they can be effectively used to build up and repair the body (1, 2). Particularly with reference to cruciferous vegetables, they have been well known for their striking cardioprotective, antimicrobial and anticarcinogenic effects. Various types of vegetables are cultivated at the diversified agro climate areas of Pakistan (3). In the modern era, nature and natural resources are underutilized and underestimated especially by the young generation (4). This is the reason even leading to various illnesses along with micronutrient deficiencies (5). There is dire need to utilize naturally occurring vegetables as well as fruits for better health along with an active lifestyle. Raphanus caudatus (family Brassicaceae) commonly known as Rat-tailed radish belonging to radish plant is considered as one of the ignored vegetable (6). This vegetable becomes available between the months of November to March. So far few studies have been reported regarding its pharmacological potential. Previously we reported substantial antidepressant activity of Raphanus caudatus in a mouse model (7). Radish (Raphanus sativus) is well-identified for significant pharmacological potential (8) (Fig. 1). Hence, Raphanus caudatus was particularly selected to precisely identify its neuropharmacological potential on sedation and motor coordination by using rodent model.

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Section: Grouping and Dosingmentioning

confidence: 99%

Neuropharmacological Evaluation of Sedative and Muscle Relaxant Properties of Raphanus Caudatus in Albino Mice

Younus¹,

Siddiq²,

Sadaf³

2019

Acta Poloniae Pharmaceutica - Drug Research

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“…According to the Shandong Total Diet Study, the average consumption of radishes is 74.81 g for adults, 43.62 g for children, and 31.58 g for toddlers. Besides the nutritional values, medical properties of the radish have also been recorded, such as antioxidant (Kim et al., 2017), antimicrobial (Beevi et al., 2009), anticancer (Pocasap et al., 2013), and anxiety reducing (Siddiq & Younus, 2018). In addition, the radish extracts have been employed to treat constipation, stomach disorders, hepatic inflammation, urinary infections, ulcers, and cardiac disorders (Goyeneche et al., 2015; Manivannan et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

Pesticide residues and dietary risk assessment in radishes in Shandong

Jiang

Zhuang

Xiao

et al. 2022

Journal of Food Science

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Pesticide residues in radishes can induce serious health hazards, especially in children and toddlers. In order to assess potential health risk from pesticide residues in radishes, a total of 26 pesticides were evaluated by gas chromatography with mass spectrometry in 1690 samples, which were collected from the year 2016 to 2019 in Shandong Province of China. All the 26 pesticide residues were detected in 752 radish samples (44.50%), but only 221 samples (13.08%) contained detectable pesticide residues, which are above the maximum residue limits (MRLs). Multiple residues with two to nine pesticides were present in 5.09% (86 out of 1690) of samples. Hazard quotient (HQ) and the cumulative risk index were far below 100, while percentage value of acute reference dose (%ARfD) of triazophos exceeded 100 for adults, children, and toddlers. The %ARfD value for carbofuran, aldicarb, monocrotophos, and parathion was over 100 for toddlers.From the perspective of public health, the occurrence of pesticide residues in radishes could not pose a serious health risk problem, but the acute health risk should be paid more attention, especially to toddlers. It is recommended to make strict regulations on the management of pesticide residues and human health risk assessment about pesticide residues.

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“…Previously various pharmacological activities of radish pods were explored by our research project (Younus and Siddiq 2017, Siddiq and Younus 2018, Younus and Siddiq 2022). In the current study, anti-inflammatory potential of this vegetable along with its effect on hematological parameters were identified by employing in vitro and in vivo experimental designs.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2022

Pak. J. Pharm. Sci.,

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The pods of Radish are known as Raphanus caudatus that belongs to the family Brassicaceae. They are commonly known as Mungra or Sungra in Pakistan, while the common English name for this species is Rat-tailed radish. This variety of radish is unique and less tested for pharmacological as well as toxicological potential. In the current research, the ethanol extract of pods was assessed for anti-inflammatory potential in vitro and in vivo. Furthermore the effect of plant on hematological parameters was also investigated. For in vitro study, luminol-enhanced chemiluminescence method was used while in vivo study was carried out via Acetic acid-induced Paw Edema Test in wistar rats. The extract of Raphanus caudatus indicated significant anti-inflammatory effects regarding in vitro assay. Administered tested doses (250mg, 500mg and 1000mg/kg) of plant extract showed significant reduction in rat's paw but highest in vivo anti-inflammatory effect was observed at the dose of 1000mg/kg. Moreover, in the case of hematological study, noticeable elevation of white blood cell count was observed at 500 and 1000 mg/kg. However the number of platelets was reduced in dose dependent manner.

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The Radish, Raphanus sativus L. Var. caudatus reduces anxiety-like behavior in mice

Cited by 9 publications

References 17 publications

Neuropharmacological Evaluation of Sedative and Muscle Relaxant Properties of Raphanus Caudatus in Albino Mice

Neuropharmacological Evaluation of Sedative and Muscle Relaxant Properties of Raphanus Caudatus in Albino Mice

Pesticide residues and dietary risk assessment in radishes in Shandong

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