“…Possible preventive and therapeutic interventions over fluid collection such as fibrin glue, talcum, and Picibanil (OK- 432) are performed to cause obliteration of leaking lymphatic vessels [ 33 , 34 , 35 ]. Lymphatic vessel coagulation and the presence of relevant scarring of the dead space that remains after lymphatic and adipose tissue removal, which prevents the lymph flow from re-routing, are responsible for the high incidence of secondary lymphedema, namely, up to 70% [ 36 ], with the highest risk in cases of wound infection, older age, obesity, or adjuvant radiation therapy [ 37 , 38 , 39 , 40 , 41 ].…”