The radiosensitivity of melanoma cells in culture

Dewey, D. L.

doi:10.1259/0007-1285-44-526-816

Cited by 162 publications

(36 citation statements)

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“…This practice is based on in vitro and in vivo studies that proposed that melanoma's radioresistance results from an unusually large "shoulder" in the radiation cell survival curve, suggesting the ability of cells to repair large amounts of sublethal radiation damage 28,29 . However, clinical studies of hypofractionation have shown mixed results 27,30 , and the optimal rt fractionation for melanoma remains controversial.…”

Section: Discussionmentioning

confidence: 99%

Malignant Melanoma Metastatic to the Larynx: Treatment and Functional Outcome

et al. 2010

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The review considers management strategies for malignant melanoma metastatic to the larynx. This rare clinical entity lacks clear treatment recommendations because extirpative surgery can often result in severe functional debilitation in patients with limited life expectancy. Here, we report a case of melanoma metastatic to the larynx in a patient with a prior history of Hodgkin lymphoma. The patient was treated with partial laryngectomy and local radiation therapy. The rationale for treatment decisions and for surgical and radiotherapeutic techniques and the associated literature are discussed.

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Section: Discussionmentioning

confidence: 99%

Malignant Melanoma Metastatic to the Larynx: Treatment and Functional Outcome

et al. 2010

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“…Other studies have used hypofractionation schedules in their patients. The rationale for this is based on radiobiologic evaluations showing a peculiar behavior of melanoma cells, which display a typical broad shoulder in their survival curves, suggesting a higher capacity to repair sublethal damage [33] . Harwood and Cummings [34] analyzed local control related to the fraction size of primary irradiation for mucosal melanomas and reported that significantly more patients treated with a dose/fraction 6 4 Gy achieved complete regression compared with those receiving a dose/fraction !…”

Section: Discussionmentioning

confidence: 99%

Postoperative Adjuvant Radiation Therapy in the Treatment of Primary Head and Neck Mucosal Melanomas

Nakashima¹,

Viégas²,

Fassizoli³

et al. 2008

ORL

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Background/Aims: The role of postoperative radiotherapy (PORT) in head and neck mucosal melanomas (HNMM) is not yet clearly defined. The aim of this study is to report the 21-year experience of the Brazilian National Cancer Institute in such treatment. Methods: From January 1983 to December 2003, 31 patients with confirmed histological diagnosis of HNMM underwent treatment at the Brazilian National Cancer Institute. Of these, 20 received radical treatment with surgery alone (8 patients – group 1) or surgery and PORT (12 patients – group 2). Results: Local control and the median time to local failure at 5 years were 75% and 14 months for group 1 and 83.5% and 40 months for group 2 (p = 0.06). The overall survival rates at 3 years were 37.5% for group 1 and 58% for group 2. At 5 years the survival rates were 25% for both groups (p = NS). When PORT was initiated within 60 days after surgery, there was a trend towards improvement in overall survival (p = 0.08). After univariate analysis, distant metastasis, location of primary disease and tobacco smoking were important prognostic factors. Conclusion: Early (<60 days) PORT for HNMM provides better local control with a longer disease-free survival.

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“…Broad-shouldered survival curves with relatively low Do-values have been reported for melanoma cells irradiated under aerobic conditions .in vitro (DEWEY 1971, BARRANCO et coll. 1971.…”

Section: E K Rofstad and T Brustadmentioning

confidence: 93%