The radiological excision of high risk and malignant lesions using the INTACT breast lesion excision system. A case series with an imaging follow up of at least 5 years

Breast Lesion Excision System in the diagnosis and treatment of intraductal papillomas – A feasibility study

“…Among the 76 patients, they reported that 13 out of the 15 papillomas and all four ADH lesions were completely removed by BLES. In the other study by Allen et al [10] 41 patients underwent BLES procedure in order to completely excise a high-risk or malignant lesion. The margins were clear for three out of the nine HRL and for 15 out of the 23 DCIS.…”

A systematic review on the use of the Breast Lesion Excision System in breast disease

“…Five hundred eighteen articles were excluded because they did not use the BLES device or a prototype. We identified 19 full-text versions of studies that used the BLES as a diagnostic or therapeutic device and that fulfilled all the inclusion criteria [4][5][6][7][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Figure 3 shows the results of the study search and identification of eligible studies.…”

“…Ten studies used stereotactic guidance during the BLES procedure [4,6,7,9,11,13,15,16,20,22]. Six studies used stereotactic or ultrasound guidance [5,10,12,14,21,23]; only Graham [17] performed all BLES procedures with ultrasound guidance.…”

“…4. In five studies, the risk of bias in patient selection was considered uncertain due to unreported details [5,[11][12][13][14]. The study of Scaperrotta et al [16] was considered to present a high risk of bias in patient selection since patients were not consecutively enrolled.…”

“…Only two studies have investigated the ability to use BLES as a therapeutic device for removal of lesions for which histological results were already obtained by other means [21,23]. An additional three studies assessed the therapeutic value of the system without prior knowledge of histology [16,20,22], and several studies reported the complete excision rate of biopsied lesions, even though they did not aim to excise the entire lesion [4,5,[9][10][11][12][13][14]. See Table 3.…”