The radioactive bromide partition test in the diagnosis of tuberculous meningitis in children

Wiggelinkhuizen, J; Mann, M. D.

doi:10.1016/s0022-3476(80)80286-1

Cited by 21 publications

(13 citation statements)

References 11 publications

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“…However, many of the studies in these groups had small sample sizes, none reported having used blinded test interpretation and in only one 216 was the patient sample judged to be representative. These factors combined mean that the evidence for the accuracy of these tests in detecting TB infection is not yet proven.…”

Section: Discussionmentioning

confidence: 99%

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

Dinnes¹,

Deeks²,

Kunst³

et al. 2007

Health Technol Assess

530

361

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Section: Discussionmentioning

confidence: 99%

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

Dinnes¹,

Deeks²,

Kunst³

et al. 2007

Health Technol Assess

530

361

View full text Add to dashboard Cite

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“…The partition test is particularly useful in distinguishing early tuberculous meningitis from viral meningitis (Wiggelinkhuizen and Mann 1980). The partition of certain ions between serum and CSF after a loading dose reflects the integrity of the blood-brain barrier (Daniel 1987).…”

Section: Partition Testmentioning

confidence: 99%

“…8 2 Br is the traditional radio-421 pharmaceutical but DTPA has the advantage of easier availability (von Wenzel et al 1989). Following intravenous or oral administration (Wiggelinkhuizen and Mann 1980), the ratio of the activity in the blood to that in the CSF is measured at 48 h for 82Br (Girgis et al 1990) and at 24 h for DTPA (von Wenzel et al 1989). In normal subjects, the concentration in plasma is 2.5-3.5 times that in lumbar CSF and 3-5 times that in ventricular CSF.…”

Section: Partition Testmentioning

confidence: 99%

“…The concentration gradient between plasma and CSF appears to be maintained by an active transport system in the choroid plexus, and proximity to the plexus probably accounts for the differences in the levels in lumbar and ventricular CSF. The radiopharmaceuticals cross the blood-brain barrier to a greater extent in patients with meningitis, more so in tuberculous than in viral (Wiggelinkhuizen and Mann 1980). Both tracers thus yield decreased serum to CSF concentration ratios in patients with tuberculous meningitis (von Wenzel et al 1989;Girgis et al 1990).…”

Section: Partition Testmentioning

confidence: 99%

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Radionuclides in Pulmonary and Extra-Pulmonary Tuberculosis

Hamilton

Al-Nabulsi

2004

Tuberculosis

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“…Several new methodologies and techniques have been developed over the course of time, such as the bromide partition test, 19,20 lactate dehydrogenase assay, 21 adenosine deaminase assay, 22 immunoglobulin-G (IgG) assay 23 etc., but none has yet been stated to be a fool-proof method. The polymerase chain reaction (PCR), a relatively new technique for the diagnosis of TBM, is also not fool-proof, and is expensive for many developing countries.…”

Section: Introductionmentioning

confidence: 99%

Proton MR CSF analysis and a new software as predictors for the differentiation of meningitis in children

et al. 2004

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This article describes proton MR spectroscopic analysis of cerebrospinal fluid of 167 children suffering from meningitis and 24 control cases. Quantification of 12 well-separated and commonly observed cerebrospinal fluid metabolites viz., -hydroxybutyrate, lactate, alanine, acetate, acetone, acetoacetate, pyruvate, glutamine, citrate, creatine/creatinine, glucose (total) and urea was carried out using Bruker's NMRQUANT software with respect to a known concentration of sodium-3-(trimethylsilyl)-2,2,3,3-d 4 -propionate (TSP), serving as an external reference. The assignment of urea in CSF is reported for the first time by NMR. The presence of cyclopropane, observed for the first time in tuberculous meningitis overall in 85.1% of cases, acts as a finger-print marker for the differential diagnosis. Multivariate discriminant function analysis was carried out for the proton MR-detected metabolite information and the clinical symptoms data of the meningitis and control cases to find the important descriptors for classification, followed by a re-validation of the entire database. It was found that the control could be differentiated from the disease group with a success rate of 96.4%, followed by the differential diagnosis of tuberculous meningitis with a corresponding value of 77.2%. Excluding the presence of cyclopropane, bacterial meningitis could be classified 84.4% correct and viral meningitis with a rate of 83.3%. It is proposed that the NMR spectroscopic information, along with other routine clinical features, may serve as an additional diagnostic tool for the differential diagnosis of meningitis in children.

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The radioactive bromide partition test in the diagnosis of tuberculous meningitis in children

Cited by 21 publications

References 11 publications

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

Radionuclides in Pulmonary and Extra-Pulmonary Tuberculosis

Proton MR CSF analysis and a new software as predictors for the differentiation of meningitis in children

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