The Radio-Sensitizing Effect of Pharmacological Concentration of Ascorbic Acid on Human Pancreatic Cancer Cells

Dayer, Dian; Tabandeh, Mohammad Reza; Kazemi, Majid

doi:10.2174/1871520620666200612144124

Cited by 8 publications

(2 citation statements)

References 25 publications

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“…Similarly promising, high-dose VitC has also been found to act as a radio-sensitizer during radiation or chemo-radiation of pre-clinical cancer models, with high specificity for cancer cells over healthy cells [16,87,89,110,111,[185][186][187][188][189][190].…”

Section: Pre-clinical Studies Using Vitc In Combination With Chemotherapy and Radiation Therapymentioning

confidence: 99%

High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

Böttger

Vallés-Martí

Cahn

et al. 2021

J Exp Clin Cancer Res

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Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer agent when administered intravenously and in high doses (high-dose IVC). Early phase clinical trials have confirmed safety and indicated efficacy of IVC in eradicating tumour cells of various cancer types. In recent years, the multi-targeting effects of vitamin C were unravelled, demonstrating a role as cancer-specific, pro-oxidative cytotoxic agent, anti-cancer epigenetic regulator and immune modulator, reversing epithelial-to-mesenchymal transition, inhibiting hypoxia and oncogenic kinase signalling and boosting immune response. Moreover, high-dose IVC is powerful as an adjuvant treatment for cancer, acting synergistically with many standard (chemo-) therapies, as well as a method for mitigating the toxic side-effects of chemotherapy. Despite the rationale and ample evidence, strong clinical data and phase III studies are lacking. Therefore, there is a need for more extensive awareness of the use of this highly promising, non-toxic cancer treatment in the clinical setting. In this review, we provide an elaborate overview of pre-clinical and clinical studies using high-dose IVC as anti-cancer agent, as well as a detailed evaluation of the main known molecular mechanisms involved. A special focus is put on global molecular profiling studies in this respect. In addition, an outlook on future implications of high-dose vitamin C in cancer treatment is presented and recommendations for further research are discussed.

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Section: Pre-clinical Studies Using Vitc In Combination With Chemotherapy and Radiation Therapymentioning

confidence: 99%

High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

Böttger

Vallés-Martí

Cahn

et al. 2021

J Exp Clin Cancer Res

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“…The absorbance of the samples was measured at 570 nm using an ELISA reader (Bio-Rad, Berkeley, CA, USA). The viability of the cells was calculated using the formula: 100 − (absorbance test/absorbance control) × 100 [ 29 ]. The IC 50 values were calculated using Prism software.…”

Section: Methodsmentioning

confidence: 99%

Evaluating the Magnolol Anticancer Potential in MKN-45 Gastric Cancer Cells

et al. 2023

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Background and Objectives: Combination therapy improves the effect of chemotherapy on tumor cells. Magnolol, used in treating gastrointestinal disorders, has been shown to have anti-cancer properties. We investigated the synergistic effect of cisplatin and magnolol on the viability and maintenance of MKN-45 gastric cancer cells. Materials and Methods: The toxicity of magnolol and/or cisplatin was determined using the MTT technique. The trypan blue method was used to test magnolol and/or cisplatin’s effect on MKN-45 cell growth. Crystal violet staining was used to assess the treated cells’ tendency for colony formation. The expression of genes linked to apoptosis, cell cycle arrest, and cell migration was examined using the qPCR method. Results: According to MTT data, using magnolol and/or cisplatin significantly reduced cell viability. The ability of the treated cells to proliferate and form colonies was also reduced considerably. Magnolol and/or cisplatin treatment resulted in a considerable elevation in Bax expression. However, the level of Bcl2 expression was dramatically reduced. p21 and p53 expression levels were significantly increased in the treated cells, while MMP-9 expression was significantly reduced. Conclusions: These findings show that magnolol has a remarkable anti-tumor effect on MKN-45 cells. In combination with cisplatin, magnolol may be utilized to overcome cisplatin resistance in gastric cancer cells.

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The Role of Vitamin C in the Prevention and Treatment of Cancers

Cheng,

Zhou,

et al. 2024

Hydrophilic Vitamins in Health and Disease

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The Radio-Sensitizing Effect of Pharmacological Concentration of Ascorbic Acid on Human Pancreatic Cancer Cells

Cited by 8 publications

References 25 publications

High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

Evaluating the Magnolol Anticancer Potential in MKN-45 Gastric Cancer Cells

The Role of Vitamin C in the Prevention and Treatment of Cancers

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