The radio-protective effect of rosmarinic acid against mobile phone and Wi-Fi radiation-induced oxidative stress in the brains of rats

Asl, Jafar Fatahi; Goudarzi, Mehdi; Shoghi, Hamed

doi:10.1007/s43440-020-00063-9

Cited by 18 publications

(16 citation statements)

References 44 publications

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“…The effects of exposure on this readout were measured once after an exposure period of 45 days, suggesting that prolonged RF-EMF exposure did not lead to exhaustion of ROS production and/or adaptation in this case. Similarly, RF-EMF (915 MHz, 0.79 mW/cm 2 ) exposure of male Wistar rats for 1 h/day for 1 month resulted in increased oxidative stress and NO formation and reduced antioxidant markers [ 50 ]. These purely descriptive studies have limitations, especially when a cell phone was used for exposure, dosimetry was missing, and/or no SAR value or dose was provided.…”

Section: Impact Of Emf On the Nervous Systemmentioning

confidence: 99%

“…There have been only a few studies in Wistar rats exposed to a Wireless Fidelity (WiFi) signal (2.45 GHz) [ 50 , 59 , 60 , 61 ]. Othman et al found impaired neurodevelopment in offspring during the first 17 postnatal days, an increase in cerebral ROS and lipid peroxidation on postnatal day 28 but not 43 after prenatal exposure for 2 h/day, and decreased antioxidant levels (CAT, SOD) [ 61 ], indicating an exhaustion of the antioxidative capacity in the brain.…”

Section: Impact Of Emf On the Nervous Systemmentioning

confidence: 99%

“…[ 59 ]. Albeit having some methodological shortcomings, the study by Asl et al also showed increased ROS and NO production in rats exposed to RF-EMF/WiFi (2450 MHz; 0.98 mW/cm 2 ) [ 50 ].…”

Section: Impact Of Emf On the Nervous Systemmentioning

confidence: 99%

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Manmade Electromagnetic Fields and Oxidative Stress—Biological Effects and Consequences for Health

Schuermann

Mevissen

2021

IJMS

102

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Concomitant with the ever-expanding use of electrical appliances and mobile communication systems, public and occupational exposure to electromagnetic fields (EMF) in the extremely-low-frequency and radiofrequency range has become a widely debated environmental risk factor for health. Radiofrequency (RF) EMF and extremely-low-frequency (ELF) MF have been classified as possibly carcinogenic to humans (Group 2B) by the International Agency for Research on Cancer (IARC). The production of reactive oxygen species (ROS), potentially leading to cellular or systemic oxidative stress, was frequently found to be influenced by EMF exposure in animals and cells. In this review, we summarize key experimental findings on oxidative stress related to EMF exposure from animal and cell studies of the last decade. The observations are discussed in the context of molecular mechanisms and functionalities relevant to health such as neurological function, genome stability, immune response, and reproduction. Most animal and many cell studies showed increased oxidative stress caused by RF-EMF and ELF-MF. In order to estimate the risk for human health by manmade exposure, experimental studies in humans and epidemiological studies need to be considered as well.

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Section: Impact Of Emf On the Nervous Systemmentioning

confidence: 99%

Section: Impact Of Emf On the Nervous Systemmentioning

confidence: 99%

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Manmade Electromagnetic Fields and Oxidative Stress—Biological Effects and Consequences for Health

Schuermann

Mevissen

2021

IJMS

102

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“…Asl et al showed that rosmarinic acid plays a crucial role in the elevation of protein nitric oxide, malondialdehyde, carbonylation, and significant reduction of total antioxidant capacity, glutathione, glutathione peroxidase, catalase, and superoxide dismutase in the radio frequency radiation-exposed rats' brain compared to the control group. Hence, it may protect against oxidative stress via ameliorative effects on the antioxidant activities in brain tissues (Asl et al, 2020 ). In another study, Satoh et al found out that CA obtained from R. officinalis binds to specific Keap1 cysteine residues, leading to the activation of the Keap1/Nrf2 transcriptional pathway, causing protection of neurons against excitotoxicity and oxidative stress, in an in vivo and in vitro model (Satoh et al, 2008 ).…”

Section: Methodsmentioning

confidence: 99%

Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender

Faridzadeh

Salimi²,

Ghasemirad³

et al. 2022

Front. Neurosci.

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Hundreds of millions of people around the world suffer from neurological disorders or have experienced them intermittently, which has significantly reduced their quality of life. The common treatments for neurological disorders are relatively expensive and may lead to a wide variety of side effects including sleep attacks, gastrointestinal side effects, blood pressure changes, etc. On the other hand, several herbal medications have attracted colossal popularity worldwide in the recent years due to their availability, affordable prices, and few side effects. Aromatic plants, sage (Salvia officinalis), lavender (Lavandula angustifolia), and rosemary (Salvia Rosmarinus) have already shown anxiolytics, anti-inflammatory, antioxidant, and neuroprotective effects. They have also shown potential in treating common neurological disorders, including Alzheimer's disease, Parkinson's disease, migraine, and cognitive disorders. This review summarizes the data on the neuroprotective potential of aromatic herbs, sage, lavender, and rosemary.

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“…Besides, inflammation and apoptosis, as two crucial phenomena in close interconnections with oxidative stress, play essential roles in post-radiation neurodegenerative processes. Nowadays, studies have introduced phenolic compounds and other candidate phytochemicals as promising antioxidant, anti-apoptotic, and anti-inflammatory agents in neurodegeneration [ 167 - 169 ]. Fig.…”

Section: Natural Products Target Oxidative Stress Inflammation and Ap...mentioning

confidence: 99%

Phytochemicals Targeting Oxidative Stress, Interconnected Neuroinflammatory, and Neuroapoptotic Pathways Following Radiation

Fakhri

Piri

Moradi

et al. 2022

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Background: Withania somnifera (WS), also known as Ashwagandha, is commonly used in Ayurveda and other traditional medicine systems. WS has seen growing, worldwide use by the public due to its reputation as an adaptogen. This popularity has elicited increased scientific study of its biological effects, including a potential application for neuropsychiatric and neurodegenerative disorders. Objective: This review aims to provide a comprehensive summary of preclinical and clinical studies examining the neuropsychiatric effects of WS, specifically its application in stress, anxiety, depression, and insomnia. Methods: Reports of human trials and animal studies of WS were collected primarily from the PubMed, Scopus, and Google Scholar databases. Results : WS root and leaf extracts exhibited noteworthy anti-stress and anti-anxiety activity in animal and human studies. WS also improved symptoms of depression and insomnia, though fewer studies investigated these applications. WS may alleviate these conditions predominantly through modulation of the hypothalamic-pituitary-adrenal and sympathetic-adrenal medullary axes, as well as through GABAergic and serotonergic pathways. While some studies link specific withanolide components to its neuropsychiatric benefits, there is evidence for the presence of additional, yet unidentified, active compounds in WS. Conclusion: While benefits were seen in the reviewed studies, significant variability in the WS extracts examined prevents a consensus on the optimum WS preparation or dosage to treat neuropsychiatric conditions. WS appears generally safe for human use; however, it will be important to investigate potential herb-drug interactions involving WS if used alongside pharmaceutical interventions. Further elucidation of active compounds of WS is also needed.

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The radio-protective effect of rosmarinic acid against mobile phone and Wi-Fi radiation-induced oxidative stress in the brains of rats

Cited by 18 publications

References 44 publications

Manmade Electromagnetic Fields and Oxidative Stress—Biological Effects and Consequences for Health

Manmade Electromagnetic Fields and Oxidative Stress—Biological Effects and Consequences for Health

Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender

Phytochemicals Targeting Oxidative Stress, Interconnected Neuroinflammatory, and Neuroapoptotic Pathways Following Radiation

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