The Racemose Form of Cerebral Cysticercosis

Bickerstaff, Edwin R.; Cloake, P. C. P.; Hughes, Brodie; Smith, William Thomas Lingwood

doi:10.1093/brain/75.1.1

Cited by 69 publications

(36 citation statements)

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“…Two major types of NCC exist depending on whether the cysts are located within the brain parenchyma or outside of it. This distinction was evident early on to clinicians, 8,9 who referred to extraparenchymal NCC as 'malignant' NCC due to its progressive nature and poor prognosis. In contrast, intraparenchymal NCC has a much better prognosis.…”

Section: Types Of Nccmentioning

confidence: 99%

“…It is also associated with marked inflammation and increased proteins and cells in the CSF resulting from continued exposure to parasite membrane remnants. 8,9,17 Several types of extraparenchymal NCC can be differentiated. Some of the most clearly defined include cysts or cyst masses in the Sylvian fissure, 18 cysticercosis of the basal cisterns (basal subarachnoid NCC), 8,9,17 or intraventricular NCC, which in turn shows particular characteristics depending on whether the cysts are in the lateral ventricles, the third or the fourth ventricle (Fig.…”

Section: Types Of Nccmentioning

confidence: 99%

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Current status and future perspectives on the medical treatment of neurocysticercosis

Gonzáles¹,

Garcı́a

2012

Pathogens and Global Health

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Neurological disease resulting from neurocysticercosis (NCC) is common in most of the world. The variability in the biology of the infection and in its clinical manifestations has led to much confusion regarding appropriate management. Therapeutic options have evolved from surgery, symptomatic measures, and steroids, to include the use of anti-parasitic drugs and minimally invasive neurosurgery. This manuscript reviews the principles of medical therapy for NCC, from discussion of the need for individualized management approaches for each type of NCC to exploration of the most likely potential additions or modifications currently under study.

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Section: Types Of Nccmentioning

confidence: 99%

Section: Types Of Nccmentioning

confidence: 99%

Current status and future perspectives on the medical treatment of neurocysticercosis

Gonzáles¹,

Garcı́a

2012

Pathogens and Global Health

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“…Extraparenchymal infection may cause hydrocephalus by mechanical obstruction of the ventricles or the basal cisterns, either by the cysts themselves or by an inflammatory reaction (ependymitis and/or arachnoiditis). The so-called racemose variety occurs in the ventricles or basal cisterns and is characterized by abnormal growth of cystic membranes with degeneration of the parasite's head (scolex) (10,84). These cases follow a progressive course, and even after ventricular shunting, the membranes or inflammatory cells and proteins frequently block the shunt.…”

Section: The Diseasementioning

confidence: 99%

Current Consensus Guidelines for Treatment of Neurocysticercosis

et al. 2002

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Taenia solium neurocysticercosis is a common cause of epileptic seizures and other neurological morbidity in most developing countries. It is also an increasingly common diagnosis in industrialized countries because of immigration from areas where it is endemic. Its clinical manifestations are highly variable and depend on the number, stage, and size of the lesions and the host's immune response. In part due to this variability, major discrepancies exist in the treatment of neurocysticercosis. A panel of experts in taeniasis/cysticercosis discussed the evidence on treatment of neurocysticercosis for each clinical presentation, and we present the panel's consensus and areas of disagreement. Overall, four general recommendations were made: (i) individualize therapeutic decisions, including whether to use antiparasitic drugs, based on the number, location, and viability of the parasites within the nervous system; (ii) actively manage growing cysticerci either with antiparasitic drugs or surgical excision; (iii) prioritize the management of intracranial hypertension secondary to neurocysticercosis before considering any other form of therapy; and (iv) manage seizures as done for seizures due to other causes of secondary seizures (remote symptomatic seizures) because they are due to an organic focus that has been present for a long time

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“…A racemose form may de velop in which the cyst resembles a cluster of grapes, 5 mm to 9 cm in diameter. The racemose form usually fails to develop a protoscolex for unknown reasons [14,25], Over years, an inflammatory reaction (chronic men ingitis and/or ventriculitis) develops presumably due to leakage of cysticercus antigens. A thick fibrous arach noiditis may encase the racemose cyst causing a mass which can obstruct CSF pathways and cause hydroceph alus [26].…”

Section: Pathogenesismentioning

confidence: 99%

Neurocysticercosis: Neurologic, Pathogenic, Diagnostic and Therapeutic Aspects

Davis¹,

Kornfeld²

1991

Eur Neurol

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Worldwide neurocysticercosis is the most common parasitic infection of the human brain and meninges. Clinical features of the illness vary with the stage of ova infection, but most problems arise when the mature cyst degenerates. Seizures, increased intracranial pressure, and focal neurologic signs then often develop. Computed tomography and magnetic resonance usually demonstrate Cysticercus cellulosae cysts in the brain. A new immunoblot test for antibodies to the cysticercus seems both sensitive and specific. Treatment with praziquantel or albendazole has hastened the disappearance of the cysts on computed tomography and improved clinical symptoms.

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The Racemose Form of Cerebral Cysticercosis

Cited by 69 publications

References 0 publications

Current status and future perspectives on the medical treatment of neurocysticercosis

Current status and future perspectives on the medical treatment of neurocysticercosis

Current Consensus Guidelines for Treatment of Neurocysticercosis

Neurocysticercosis: Neurologic, Pathogenic, Diagnostic and Therapeutic Aspects

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